Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption

2016 ◽  
Vol 500 (1-2) ◽  
pp. 275-290 ◽  
Author(s):  
Lucia Grumetto ◽  
Giacomo Russo ◽  
Francesco Barbato
Keyword(s):  
Intestinal Absorption ◽  
Cell Line ◽  
Cultured Cell ◽  
Human Intestinal Absorption ◽  
Cultured Cell Line ◽  
Polar Interactions

Further studies on the enzymic pattern of a cultured cell line from liver

1959 ◽  
Vol 31 (1) ◽  
pp. 268-269 ◽  
Author(s):  
Victor H. Auerbach ◽  
Duard L. Walker
Keyword(s):  
Cell Line ◽  
Cultured Cell ◽  
Cultured Cell Line

scholarly journals Trifluoperazine inhibits phagocytosis in a macrophagelike cultured cell line.

1981 ◽  
Vol 91 (3) ◽  
pp. 798-802 ◽  
Author(s):  
S B Horwitz ◽  
G H Chia ◽  
C Harracksingh ◽  
S Orlow ◽  
S Pifko-Hirst ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cell Line ◽  
Cyclic Nucleotide ◽  
Cellular Function ◽  
Inhibitory Effects ◽  
Cultured Cell ◽  
Sulfonamide Derivative ◽  
Cultured Cell Line ◽  
Macrophagelike Cell

Trifluoperazine, a drug that binds to Ca2+-calmodulin and inhibits its interaction with other proteins, was found to inhibit growth and phagocytosis in a macrophagelike cell line, J774.16. Both effects were reversible and occurred at the same concentrations of drug (25--50 microM) that inhibited the activation of cyclic nucleotide phosphodiesterase by calmodulin in vitro. Fc-mediated phagocytosis was also depressed by W-7, a sulfonamide derivative that inhibits the activity of Ca2+-calmodulin. In contrast, taxol, a drug that stabilizes cellular microtubules, had no effect on Fc-mediated phagocytosis although it inhibited cell growth at nanomolar concentrations. The inhibitory effects of trifluoperazine and W-7 on phagocytosis suggest that calmodulin may be involved in this complex cellular function.

Alpha-fetoprotein-producing gastric carcinoma: Biological properties of a cultured cell line

1995 ◽  
Vol 30 (5) ◽  
pp. 589-598 ◽  
Author(s):  
Morimasa Sekiguchi ◽  
Yuzo Fujii ◽  
Atsuko Saito ◽  
Toshimitsu Suzuki ◽  
Yasuko Shiroko ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Cell Line ◽  
Biological Properties ◽  
Alpha Fetoprotein ◽  
Cultured Cell ◽  
Cultured Cell Line

scholarly journals Study on frozen preservation of Tawa sarcoma and its cultured cell line in liquid nitrogen

1978 ◽  
Vol 20 (2) ◽  
pp. 238-251
Author(s):  
Toshikazu TAWA ◽  
Noboru WAKUMOTO ◽  
Atsushi FUJITA ◽  
Hiroshi MORITA
Keyword(s):  
Cell Line ◽  
Liquid Nitrogen ◽  
Cultured Cell ◽  
Cultured Cell Line
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