Polymer-based biomaterials for chronic wound management: Promises and challenges

2021 ◽  
Vol 598 ◽  
pp. 120270
Author(s):  
Muhammad Maaz Arif ◽  
Shahzad Maqsood Khan ◽  
Nafisa Gull ◽  
Tanveer A. Tabish ◽  
Saba Zia ◽  
...  
Keyword(s):  
Chronic Wound ◽  
Wound Management ◽  
Chronic Wound Management

Fluorescent Imaging and Precise Suppression of Bacterial Infection in Chronic Wounds by Porphyrin-Based Metal-Organic Framework Nanorod

2021 ◽  
Author(s):  
zhen zou ◽  
Lihua Zhang ◽  
Minzhi Ouyang ◽  
Yufei Zhang ◽  
Huanxiang Wang ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Antibacterial Agents ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Metal Organic Framework ◽  
Critical Role ◽  
Fluorescent Imaging ◽  
Wound Management ◽  
Metal Organic ◽  
Chronic Wound Management

Nano-antibacterial agents play a critical role in chronic wound management. However, an intelligent nanosystem that can provide both visual warning of infection and precise sterilization remains a hurdle. Herein, a...

Proactive Biomaterials for Chronic Wound Management and Treatment

2021 ◽  
pp. 100327
Author(s):  
Tyler R. Priddy-Arrington ◽  
Megan S. Ward ◽  
Reagan E. Edwards ◽  
Mary E. Caldorera-Moore
Keyword(s):  
Chronic Wound ◽  
Wound Management ◽  
Chronic Wound Management

Wearable Bioelectronics for Chronic Wound Management

2021 ◽  
pp. 2111022
Author(s):  
Canran Wang ◽  
Ehsan Shirzaei Sani ◽  
Wei Gao
Keyword(s):  
Chronic Wound ◽  
Wound Management ◽  
Chronic Wound Management

Smart biomaterial-based systems for intrinsic stimuli-responsive chronic wound management

2021 ◽  
Vol 22 ◽  
pp. 100623
Author(s):  
P.M. Alves ◽  
C.C. Barrias ◽  
P. Gomes ◽  
M.C.L. Martins
Keyword(s):  
Chronic Wound ◽  
Wound Management ◽  
Stimuli Responsive ◽  
Chronic Wound Management

Comparison of Skin Substitutes for Acute and Chronic Wound Management

2021 ◽  
Vol 35 (03) ◽  
pp. 171-180
Author(s):  
Caroline Bay ◽  
Zachary Chizmar ◽  
Edward M. Reece ◽  
Jessie Z. Yu ◽  
Julian Winocour ◽  
...  
Keyword(s):  
Chronic Wound ◽  
Relevant Literature ◽  
Wound Management ◽  
Foot Ulcers ◽  
Skin Substitute ◽  
Diabetic Foot Ulcers ◽  
Structural Elements ◽  
Skin Substitutes ◽  
Treatment Alternative ◽  
Chronic Wound Management

AbstractChronic and acute wounds, such as diabetic foot ulcers and burns, respectively, can be difficult to treat, especially when autologous skin transplantations are unavailable. Skin substitutes can be used as a treatment alternative by providing the structural elements and growth factors necessary for reepithelialization and revascularization from a nonautologous source. As of 2020, there are 76 commercially available skin substitute products; this article provides a review of the relevant literature related to the major categories of skin substitutes available.

scholarly journals Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 991 ◽  
Author(s):  
Mohamed Bazbouz ◽  
Giuseppe Tronci
Keyword(s):  
Chronic Wound ◽  
Colour Change ◽  
Single Layer ◽  
Building Blocks ◽  
High Water ◽  
Bromothymol Blue ◽  
Wound Management ◽  
Wound Exudate ◽  
Management Capability ◽  
Chronic Wound Management

The spread of antimicrobial resistance calls for chronic wound management devices that can engage with the wound exudate and signal infection by prompt visual effects. Here, the manufacture of a two-layer fibrous device with independently-controlled exudate management capability and visual infection responsivity was investigated by sequential free surface electrospinning of poly(methyl methacrylate-co-methacrylic acid) (PMMA-co-MAA) and poly(acrylic acid) (PAA). By selecting wound pH as infection indicator, PMMA-co-MAA fibres were encapsulated with halochromic bromothymol blue (BTB) to trigger colour changes at infection-induced alkaline pH. Likewise, the exudate management capability was integrated via the synthesis of a thermally-crosslinked network in electrospun PAA layer. PMMA-co-MAA fibres revealed high BTB loading efficiency (>80 wt.%) and demonstrated prompt colour change and selective dye release at infected-like media (pH > 7). The synthesis of the thermally-crosslinked PAA network successfully enabled high water uptake (WU = 1291 ± 48 − 2369 ± 34 wt.%) and swelling index (SI = 272 ± 4 − 285 ± 3 a.%), in contrast to electrospun PAA controls. This dual device functionality was lost when the same building blocks were configured in a single-layer mesh of core-shell fibres, whereby significant BTB release (~70 wt.%) was measured even at acidic pH. This study therefore demonstrates how the fibrous configuration can be conveniently manipulated to trigger structure-induced functionalities critical to chronic wound management and monitoring.

scholarly journals Negative Pressure Wound Therapy Literature Review of Efficacy, Cost Effectiveness, and Impact on Patients' Quality of Life in Chronic Wound Management and Its Implementation in the United Kingdom

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Diaa Othman
Keyword(s):  
Cost Effectiveness ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Chronic Wound ◽  
National Standard ◽  
Wound Management ◽  
Care Providers ◽  
Wound Therapy ◽  
Patients Satisfaction ◽  
Chronic Wound Management

This is a paper reviewing the National Health Service (NHS) agenda in relation to the use of Negative Pressure Wound Therapy (NPWT) in chronic wound management and assesses the evidence behind it, its cost effectiveness and the outcome it has on patients’ satisfaction and life style. Multiple studies over the last 10 years looking at clinical efficacy of NPWT with its cost effectiveness and the implementation of this service in the UK were reviewed. NPWT has showed a reasonable body of evidence to support its usage in chronic wounds with potential positive outcomes on finance and patients’ satisfaction. However, the NHS system shows significant variations in the availability and implementation of this useful tool, depending on care providers and resources availabilities. The paper concluded that the NPWT can be a useful source of cutting down costs of chronic wound managements and saving money by its effect on expediting wound healing, which can address a part of the financial crises facing the NHS, however, has to be considered according to specific case needs. There should also be a national standard for the availability and indication of this tool to assure equal opportunities for different patients in different areas in the country.

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