Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder and probiotics for effective treatment of type 2 diabetes mellitus in streptozotocin induced rats

2021 ◽  
pp. 121306
Author(s):  
Rubiya Khursheed ◽  
Sachin Kumar Singh ◽  
Bimlesh Kumar ◽  
Sheetu Wadhwa ◽  
Monica Gulati ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Effective Treatment ◽  
Ganoderma Lucidum

scholarly journals Effective Treatment of Diabetic Cardiomyopathy and Heart Failure with Reconstituted HDL (Milano) in Mice

2019 ◽  
Vol 20 (6) ◽  
pp. 1273 ◽  
Author(s):  
Joseph Aboumsallem ◽  
Ilayaraja Muthuramu ◽  
Mudit Mishra ◽  
Herman Kempen ◽  
Bart De Geest
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Effective Treatment ◽  
Diabetic Cardiomyopathy ◽  
Capillary Density ◽  
Loop Analysis ◽  
Lung Weight

The risk of heart failure (HF) is prominently increased in patients with type 2 diabetes mellitus. The objectives of this study were to establish a murine model of diabetic cardiomyopathy induced by feeding a high-sugar/high-fat (HSHF) diet and to evaluate the effect of reconstituted HDLMilano administration on established HF in this model. The HSHF diet was initiated at the age of 12 weeks and continued for 16 weeks. To investigate the effect of reconstituted HDLMilano on HF, eight intraperitoneal administrations of MDCO-216 (100 mg/kg protein concentration) or of an identical volume of control buffer were executed with a 48-h interval starting at the age of 28 weeks. The HSHF diet-induced obesity, hyperinsulinemia, and type 2 diabetes mellitus. Diabetic cardiomyopathy was present in HSHF diet mice as evidenced by cardiac hypertrophy, increased interstitial and perivascular fibrosis, and decreased myocardial capillary density. Pressure-volume loop analysis indicated the presence of both systolic and diastolic dysfunction and of decreased cardiac output in HSHF diet mice. Treatment with MDCO-216 reversed pathological remodelling and cardiac dysfunction and normalized wet lung weight, indicating effective treatment of HF. No effect of control buffer injection was observed. In conclusion, reconstituted HDLMilano reverses HF in type 2 diabetic mice.

scholarly journals Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model

2019 ◽  
Vol Volume 15 ◽  
pp. 419-427 ◽  
Author(s):  
Teuku Heriansyah ◽  
Wiwit Nurwidyaningtyas ◽  
Djanggan Sargowo ◽  
Cholid Tri Tjahjono ◽  
Titin Andri Wihastuti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ganoderma Lucidum ◽  
Vascular Repair

scholarly journals Polysaccharide Peptide (PsP) Ganoderma lucidum: A Potential Inducer For Vascular Repair In Type 2 Diabetes Mellitus Model [Corrigendum]

2019 ◽  
Vol Volume 15 ◽  
pp. 517-518
Author(s):  
Teuku Heriansyah ◽  
Wiwit Nurwidyaningtyas ◽  
Djanggan Sargowo ◽  
Cholid Tri Tjahjono ◽  
Titin Andri Wihastuti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ganoderma Lucidum ◽  
Vascular Repair

scholarly journals Pioglitazone is an effective treatment for patients with post-stroke depression combined with type 2 diabetes mellitus

2015 ◽  
Vol 10 (3) ◽  
pp. 1109-1114 ◽  
Author(s):  
YAOZHI HU ◽  
HAIYAN XING ◽  
XIAOMENG DONG ◽  
WENXIAN LU ◽  
XINXING XIAO ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Effective Treatment ◽  
Post Stroke ◽  
Post Stroke Depression

Abstract #1214: Decreasing Hypoglycemia Without Compromising Efficacy in an Aging Type 2 Diabetes Mellitus (T2Dm) Population

2015 ◽  
Vol 21 ◽  
pp. 280-281
Author(s):  
Medha Munshi ◽  
Jasvinder Gill ◽  
Jason Chao ◽  
Elena Nikonova ◽  
Andreas Stuhr ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus
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