The Role of Oxidative Stress in the Cytotoxic Effects of Erlotinib in Human Head and Neck Cancer Cells

2009 ◽  
Vol 75 (3) ◽  
pp. S565
Author(s):  
K.P. Orcutt ◽  
W.W. Wilke ◽  
P.M. Scarbrough ◽  
A.L. Kalen ◽  
D.R. Spitz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head ◽  
Cytotoxic Effects

Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress in Human Head and Neck Cancer Cells

2010 ◽  
Vol 49 ◽  
pp. S102-S103
Author(s):  
Andrean L. Simons ◽  
Kevin P. Orcutt ◽  
Arlene D. Parsons ◽  
Zita A. Sibenaller ◽  
Peter M. Scarbrough ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head ◽  
Egfr Signaling ◽  
Metabolic Oxidative Stress

scholarly journals 2-Deoxy-d-Glucose Combined with Cisplatin Enhances Cytotoxicity via Metabolic Oxidative Stress in Human Head and Neck Cancer Cells

2007 ◽  
Vol 67 (7) ◽  
pp. 3364-3370 ◽  
Author(s):  
Andrean L. Simons ◽  
Iman M. Ahmad ◽  
David M. Mattson ◽  
Kenneth J. Dornfeld ◽  
Douglas R. Spitz
Keyword(s):  
Oxidative Stress ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head ◽  
Metabolic Oxidative Stress

scholarly journals Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells

2009 ◽  
Vol 2009 ◽  
pp. 1-10 ◽  
Author(s):  
Andrean L. Simons ◽  
Arlene D. Parsons ◽  
Katherine A. Foster ◽  
Kevin P. Orcutt ◽  
Melissa A. Fath ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Reductase Activity ◽  
Thioredoxin Reductase ◽  
Buthionine Sulfoximine ◽  
Human Head ◽  
Akt Inhibitor ◽  
Simultaneous Treatment

The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSSG) in FaDu, Cal-27, and SCC-25 HNSCCs as well as causing significant clonogenic cell killing in FaDu and Cal-27, which was suppressed by simultaneous treatment with N-acetylcysteine (NAC). An inhibitor of GSH synthesis, buthionine sulfoximine (BSO), sensitized Cal-27 and SCC-25 cells to PER-induced clonogenic killing as well as decreased total GSH and increased %GSSG. Additionally, inhibition of thioredoxin reductase activity (TrxRed) with auranofin (AUR) was able to induce PER sensitization in SCC-25 cells that were initially refractory to PER. These results support the conclusion that PER induces oxidative stress and clonogenic killing in HNSCC cells that is enhanced with inhibitors of GSH and Trx metabolism.

scholarly journals Spheroid Culture of Head and Neck Cancer Cells Reveals an Important Role of EGFR Signalling in Anchorage Independent Survival

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163149 ◽  
Author(s):  
Diana Braunholz ◽  
Mohammad Saki ◽  
Franziska Niehr ◽  
Merve Öztürk ◽  
Berta Borràs Puértolas ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Spheroid Culture

scholarly journals Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e48175 ◽  
Author(s):  
Arya Sobhakumari ◽  
Laurie Love-Homan ◽  
Elise V. M. Fletcher ◽  
Sean M. Martin ◽  
Arlene D. Parsons ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head
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