COX-2 Expression Does Not Predict Biochemical Failure in Patients Treated with Salvage Radiation Therapy for Prostate Cancer

2011 ◽  
Vol 81 (2) ◽  
pp. S410-S411
Author(s):  
K.S. Tzou ◽  
S.J. Buskirk ◽  
M.G. Heckman ◽  
A.S. Parker ◽  
V. Patel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Biochemical Failure ◽  
Salvage Radiation Therapy ◽  
Cox 2

Natural history of ‘second’ biochemical failure after salvage radiation therapy for prostate cancer: a multi-institution study

2017 ◽  
Vol 121 (3) ◽  
pp. 365-372 ◽  
Author(s):  
Vasu Tumati ◽  
William C. Jackson ◽  
Ahmed E. Abugharib ◽  
Ganesh Raj ◽  
Claus Roehrborn ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Natural History ◽  
Biochemical Failure ◽  
Salvage Radiation Therapy ◽  
History Of

Interval to biochemical failure is prognostic for distant metastases after salvage radiation therapy for prostate cancer

2015 ◽  
Vol 5 (1) ◽  
pp. 79-85
Author(s):  
Nicholas George Zaorsky ◽  
Tianyu Li ◽  
Aruna Turaka ◽  
David Y. T. Chen ◽  
Eric M. Horwitz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Distant Metastases ◽  
Biochemical Failure ◽  
Salvage Radiation Therapy

scholarly journals Lack of association between COX-2 staining level and biochemical recurrence following salvage radiation therapy for recurrent prostate cancer

2013 ◽  
Vol 2 (3) ◽  
pp. 309-314
Author(s):  
Michael G. Heckman ◽  
Katherine S. Tzou ◽  
Alexander S. Parker ◽  
Thomas M. Pisansky ◽  
Steven E. Schild ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Biochemical Recurrence ◽  
Recurrent Prostate Cancer ◽  
Salvage Radiation Therapy ◽  
Cox 2

Post-prostatectomy salvage radiation therapy in prostate cancer upon identification of biochemical failure.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 127-127
Author(s):  
Suneal Gopal Peddada ◽  
Craig Oliver ◽  
Angela Phelps ◽  
Steven H. Stokes ◽  
Jarrod Bartlett Adkison
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Gleason Score ◽  
Specific Antigen ◽  
Biochemical Failure ◽  
Salvage Radiotherapy ◽  
Failure Rates ◽  
Biochemical Control ◽  
Salvage Radiation Therapy

127 Background: Prostate Specific Antigen (PSA) values post-prostatectomy are used as an indication for salvage radiation therapy. It has been suggested that initiation of therapy at lower PSA values lead to better outcomes. This study investigates outcomes of salvage radiation therapy at specific PSA thresholds. Methods: One hundred two prostate cancer patients were treated with salvage radiotherapy at our institution with curative intent, 19 of whom had Gleason score ≤6, 52 of whom had Gleason 7, and 31 with Gleason ≥8. Median follow-up after radiotherapy was 51 months. The median PSA prior to salvage radiotherapy was 0.33 ng/mL, and the median time from prostatectomy to radiotherapy was 24.6 months. Positive margins were identified in 52 patients, and perineural invasion was positive in 83. The median dose delivered was 64.8 Gy. Results: The 5-year actuarial freedom from biochemical failure rates for NCCN low, intermediate, and high risk groups were 100%, 77%, and 62%, p=0.2449. The 5-year actuarial freedom from biochemical failure rates for Gleason score ≤6, Gleason 7, and Gleason ≥8 patients were 87%, 72%, and 49%, p=0.0187. Patients with pre-radiotherapy PSA ≤0.5 ng/mL had better 5-year biochemical control relative to patients with higher pre-radiotherapy PSA, 76% versus 51%, p=0.0211. The pathological margin status did not predict for biochemical control after salvage radiation across the different Gleason grades. Very few interval biochemical failures are observed after the 5-year point of follow-up. The 5-year overall survival for the entire cohort is 92%, with prostate cancer specific survival of 96%. Conclusions: Salvage radiotherapy demonstrated favorable efficacy with durable PSA control and few failures 5 years post radiation. Initiation of salvage radiotherapy for PSA ≤0.5 ng/mL demonstrated improved biochemical control, supporting the adoption of early referral to radiation oncology once post-prostatectomy biochemical failure is identified. [Table: see text]

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