Response and Quality of Life (QOL) Outcomes in a Randomized Trial of Single Versus Multiple Fractions (Fx) for Re-irradiation (RE-RT) of Painful Bone Metastases (PBM): NCIC CTG SC.20

2013 ◽  
Vol 87 (2) ◽  
pp. S6 ◽  
Author(s):  
E. Chow ◽  
Y. Van Der Linden ◽  
D. Roos ◽  
W. Hartsell ◽  
P. Hoskin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Metastases ◽  
Randomized Trial ◽  
Painful Bone Metastases ◽  
Single Versus

scholarly journals Impact of Reirradiation of Painful Osseous Metastases on Quality of Life and Function: A Secondary Analysis of the NCIC CTG SC.20 Randomized Trial

2014 ◽  
Vol 32 (34) ◽  
pp. 3867-3873 ◽  
Author(s):  
Edward Chow ◽  
Ralph M. Meyer ◽  
Bingshu E. Chen ◽  
Yvette M. van der Linden ◽  
Daniel Roos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Metastases ◽  
Randomized Trial ◽  
Patient Perception ◽  
Dose Fractionation ◽  
Walking Ability ◽  
Life Questionnaire ◽  
Functional Interference ◽  
Painful Bone Metastases

Purpose We previously demonstrated that 48% of patients with pain at sites of previously irradiated bone metastases benefit from reirradiation. It is unknown whether alleviating pain also improves patient perception of quality of life (QOL). Patients and Methods We used the database of a randomized trial comparing radiation treatment dose fractionation schedules to evaluate whether response, determined using the International Consensus Endpoint (ICE) and Brief Pain Inventory pain score (BPI-PS), is associated with patient perception of benefit, as measured using the European Organisation for Resesarch and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) and functional interference scale of the BPI (BPI-FI). Evaluable patients completed baseline and 2-month follow-up assessments. Results Among 850 randomly assigned patients, 528 were evaluable for response using the ICE and 605 using the BPI-PS. Using the ICE, 253 patients experienced a response and 275 did not. Responding patients had superior scores on all items of the BPI-FI (ie, general activity, mood, walking ability, normal work, relations with other people, sleep, and enjoyment of life) and improved QOL, as determined by scores on the EORTC QLQ-C30 scales of physical, role, emotional and social functioning, global QOL, fatigue, pain, and appetite. Similar results were obtained using the BPI-PS; observed improvements were typically of lesser magnitude. Conclusion Patients responding to reirradiation of painful bone metastases experience superior QOL scores and less functional interference associated with pain. Patients should be offered re-treatment for painful bone metastases in the hope of reducing pain severity as well as improving QOL and pain interference.

Radiotherapy plus either transdermal fentanyl or paracetamol and codeine for painful bone metastases: a randomised study of pain relief and quality of life

2004 ◽  
Vol 20 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Kyriaki Pistevou-Gompaki ◽  
Vassilis E. Kouloulias ◽  
Charalambos Varveris ◽  
Kyriaki Mystakidou ◽  
Grigoris Georgakopoulos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pain Relief ◽  
Bone Metastases ◽  
Transdermal Fentanyl ◽  
Randomised Study ◽  
Painful Bone Metastases

scholarly journals PD-0533: Response and quality of life in elderly with painful bone metastases: results from a randomized radiotherapy study

2013 ◽  
Vol 106 ◽  
pp. S205
Author(s):  
P.G. Westhoff ◽  
A. de Graeff ◽  
A.K. Reyners ◽  
C.C. Rodenhuis ◽  
M. van Vulpen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Metastases ◽  
Painful Bone Metastases

Effect of age on response to palliative radiotherapy and quality of life in patients with painful bone metastases

2014 ◽  
Vol 111 (2) ◽  
pp. 264-269 ◽  
Author(s):  
Paulien G. Westhoff ◽  
Alexander de Graeff ◽  
Anna K.L. Reyners ◽  
Evelyn M. Monninkhof ◽  
Carla C. Rodenhuis ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Metastases ◽  
Palliative Radiotherapy ◽  
Painful Bone Metastases ◽  
Effect Of Age

scholarly journals Early palliative radiation versus observation for high-risk asymptomatic or minimally symptomatic bone metastases: study protocol for a randomized controlled trial

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Daniel B. Rosen ◽  
Cory D. Benjamin ◽  
Joanna C. Yang ◽  
Connor Doyle ◽  
Zhigang Zhang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
High Risk ◽  
Bone Metastases ◽  
Bone Pain ◽  
Patient Centered ◽  
Palliative Radiation ◽  
Effects Of Radiation ◽  
Painful Bone Metastases

Abstract Background In patients with metastatic cancer, the bone is the third-most common site of involvement. Radiation to painful bone metastases results in high rates of pain control and is an integral part of bone metastases management. Up to one-third of inpatient consults are requested for painful bone metastases, and up to 60% of these patients had evidence of these lesions visible on prior imaging. Meanwhile recent advances have reduced potential side effects of radiation. Therefore, there is an opportunity to further improve outcomes for patients using prophylactic palliative radiation to manage asymptomatic bone metastases. Methods/study design In this trial, 74 patients with metastatic solid tumors and high-risk asymptomatic or minimally symptomatic bone metastases will be enrolled and randomized to early palliative radiation or standard of care. This will be the first trial to assess the efficacy of prophylactic palliative radiation in preventing skeletal related events (SREs), the primary endpoint. This endpoint was selected to encompass patient-centered outcomes that impact quality of life including pathologic fracture, spinal cord compression, and intervention with surgery or radiation. Secondary endpoints include hospitalizations, Bone Pain Index, pain-free survival, pain-related quality of life, and side effects of radiation therapy. Discussion In this study, we propose a novel definition of high-risk bone metastases most likely to benefit from preventive radiation and use validated questionnaires to assess pain and impact on quality of life and health resource utilization. Observations from early patient enrollment have demonstrated robustness of the primary endpoint and need for minor modifications to Bone Pain Index and data collection for opioid use and hospitalizations. With increasing indications for radiation in the oligometastatic setting, this trial aims to improve patient-centered outcomes in the polymetastatic setting. Trial registration ISRCTN Number/Clinical trials.gov, ID:NCT03523351. Registered on 14 May 2018.

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