Multicentric Evaluation of Long-term Outcome After Highly Advanced Single-Dose or Fractionated Radiation Therapy in Patients With Vestibular Schwannomas: Pooled Results From 3 Large German Centers

Author(s):  
S. Combs ◽  
C. Engelhard ◽  
C. Kopp ◽  
N. Wiedenmann ◽  
J. Debus ◽  
...  
2015 ◽  
Vol 114 (3) ◽  
pp. 378-383 ◽  
Author(s):  
Stephanie E. Combs ◽  
Christina Engelhard ◽  
Christine Kopp ◽  
Nicole Wiedenmann ◽  
Oliver Schramm ◽  
...  

2010 ◽  
Vol 6 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Kyung Sun Song ◽  
Ji Hoon Phi ◽  
Byung-Kyu Cho ◽  
Kyu-Chang Wang ◽  
Ji Yeoun Lee ◽  
...  

Object Glioblastoma is the most common primary malignant brain tumor; however, glioblastoma in children is less common than in adults, and little is known about its clinical outcome in children. The authors evaluated the long-term outcome of glioblastoma in children. Methods Twenty-seven children were confirmed to have harbored a glioblastoma between 1985 and 2007. The clinical features and treatment outcomes were reviewed retrospectively. All patients underwent resection; complete resection was performed in 12 patients (44%), subtotal resection in 12 patients (44%), and biopsy in 3 patients (11%). Twenty-four patients (89%) had radiation therapy, and 14 (52%) patients received chemotherapy plus radiation therapy. Among the latter, 5 patients had radiation therapy concurrent with temozolomide chemotherapy. Four patients with small-size recurrent glioblastoma received stereotactic radiosurgery. Results The median overall survival (OS) was 43 months, and the median progression-free survival was 12 months. The OS rate was 67% at 1 year, 52% at 2 years, and 40% at 5 years. The median OS was significantly associated with tumor location (52 months for superficially located tumors vs 7 months for deeply located tumors; p = 0.017) and extent of removal (106 months for completely resected tumors vs 11 months for incompletely resected tumors; p < 0.0001). Conclusions The prognosis of glioblastoma is better in children than in adults. Radical resection followed by concurrent chemoradiation therapy may be the initial treatment of choice.


2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii4-ii4
Author(s):  
P. de Andres ◽  
A. L. Presti ◽  
M. E. Kusak ◽  
N. Martinez ◽  
J. M. de Campos ◽  
...  

Author(s):  
K. Nielsen ◽  
M.V. Maraldo ◽  
M.C. Aznar ◽  
P.M. Petersen ◽  
I. Vogelius ◽  
...  

2006 ◽  
Vol 66 (4) ◽  
pp. 1044-1050 ◽  
Author(s):  
Allen M. Chen ◽  
M. Kara Bucci ◽  
Jeanne M. Quivey ◽  
Joaquin Garcia ◽  
David W. Eisele ◽  
...  

2020 ◽  
Vol 150 ◽  
pp. 236-244
Author(s):  
Karin Nielsen ◽  
Maja Vestmoe Maraldo ◽  
Anne Kiil Berthelsen ◽  
Annika Loft ◽  
Peter de Nully Brown ◽  
...  

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