Prognostic Significance of Extracapsular Spread and Perineural and Lymphovascular Invasion in Patients with HPV- and Non-HPV–Related Oropharyngeal Squamous Cell Carcinoma.

2016 ◽  
Vol 94 (4) ◽  
pp. 898-899
Author(s):  
R. Borucki ◽  
S.A. Nguyen ◽  
E.A. Nicolli ◽  
S. Sridharan ◽  
T. Day ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphovascular Invasion ◽  
Prognostic Significance ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Extracapsular Spread

scholarly journals Spatial proximity between T and PD-L1 expressing cells as a prognostic biomarker for oropharyngeal squamous cell carcinoma

2019 ◽  
Vol 122 (4) ◽  
pp. 539-544 ◽  
Author(s):  
Anna Maria Tsakiroglou ◽  
Martin Fergie ◽  
Ken Oguejiofor ◽  
Kim Linton ◽  
David Thomson ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immune Escape ◽  
Prognostic Significance ◽  
Predictive Biomarkers ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Spatial Proximity ◽  
Spatial Interactions ◽  
Hpv Status

Abstract Background Fulfilling the promise of cancer immunotherapy requires novel predictive biomarkers to characterise the host immune microenvironment. Deciphering the complexity of immune cell interactions requires an automated multiplex approach to histological analysis of tumour sections. We tested a new automatic approach to select tissue and quantify the frequencies of cell-cell spatial interactions occurring in the PD1/PD-L1 pathway, hypothesised to reflect immune escape in oropharyngeal squamous cell carcinoma (OPSCC). Methods Single sections of diagnostic biopsies from 72 OPSCC patients were stained using multiplex immunofluorescence (CD8, PD1, PD-L1, CD68). Following multispectral scanning and automated regions-of-interest selection, the Hypothesised Interaction Distribution (HID) method quantified spatial proximity between cells. Method applicability was tested by investigating the prognostic significance of co-localised cells (within 30 μm) in patients stratified by HPV status. Results High frequencies of proximal CD8+ and PD-L1+ (HR 2.95, p = 0.025) and PD1+ and PD-L1+ (HR 2.64, p = 0.042) cells were prognostic for poor overall survival in patients with HPV negative OPSCC (n = 31). Conclusion The HID method can quantify spatial interactions considered to reflect immune escape and generate prognostic information in OPSCC. The new automated approach is ready to test in additional cohorts and its applicability should be explored in research and clinical studies.

scholarly journals Prognostic Significance of Cyclooxygenase-2 in Oropharyngeal Squamous Cell Carcinoma

2004 ◽  
Vol 10 (5) ◽  
pp. 1678-1684 ◽  
Author(s):  
Bryan W. Chang ◽  
David H. Kim ◽  
Diane P. Kowalski ◽  
Joseph A. Burleson ◽  
Yung H. Son ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Cyclooxygenase 2

The prognostic significance of age in oropharyngeal squamous cell carcinoma

Oral Oncology ◽  
2014 ◽  
Vol 50 (5) ◽  
pp. 431-436 ◽  
Author(s):  
Philip Ryan Camilon ◽  
William A. Stokes ◽  
Shaun A. Nguyen ◽  
Eric J. Lentsch
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Oropharyngeal Squamous Cell Carcinoma
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