scholarly journals Androgen Deprivation Therapy Use in the Setting of High-Dose Radiation Therapy and the Risk of Prostate Cancer–Specific Mortality Stratified by the Extent of Competing Mortality

2016 ◽  
Vol 96 (2) ◽  
pp. S139
Author(s):  
B. Rose ◽  
M.H. Chen ◽  
J. Wu ◽  
M.H. Braccioforte ◽  
B.J. Moran ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
High Dose ◽  
Specific Mortality ◽  
Cancer Specific Mortality ◽  
Competing Mortality ◽  
Dose Radiation

Comorbidity and androgen deprivation therapy use in men undergoing high-dose radiation for unfavorable-risk prostate cancer

2016 ◽  
Vol 5 (3) ◽  
pp. 293-300
Author(s):  
Michael A. Dyer ◽  
Ming-Hui Chen ◽  
Michelle H. Braccioforte ◽  
Brian J. Moran ◽  
Anthony V. D’Amico
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
High Dose ◽  
Risk Prostate Cancer ◽  
Dose Radiation

scholarly journals Effectiveness of Primary Androgen-Deprivation Therapy for Clinically Localized Prostate Cancer

2014 ◽  
Vol 32 (13) ◽  
pp. 1324-1330 ◽  
Author(s):  
Arnold L. Potosky ◽  
Reina Haque ◽  
Andrea E. Cassidy-Bushrow ◽  
Marianne Ulcickas Yood ◽  
Miao Jiang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Localized Prostate Cancer ◽  
Curative Intent ◽  
Primary Androgen Deprivation Therapy ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Cancer Specific Mortality ◽  
Primary Androgen Deprivation

Purpose Primary androgen-deprivation therapy (PADT) is often used to treat clinically localized prostate cancer, but its effects on cause-specific and overall mortality have not been established. Given the widespread use of PADT and the potential risks of serious adverse effects, accurate mortality data are needed to inform treatment decisions. Methods We conducted a retrospective cohort study using comprehensive utilization and cancer registry data from three integrated health plans. All men were newly diagnosed with clinically localized prostate cancer. Men who were diagnosed between 1995 and 2008, were not treated with curative intent therapy, and received follow-up through December 2010 were included in the study (n = 15,170). We examined all-cause and prostate cancer-specific mortality as our main outcomes. We used Cox proportional hazards models with and without propensity score analysis. Results Overall, PADT was associated with neither a risk of all-cause mortality (hazard ratio [HR], 1.04; 95% CI, 0.97 to 1.11) nor prostate-cancer–specific mortality (HR, 1.03; 95% CI, 0.89 to 1.19) after adjusting for all sociodemographic and clinical characteristics. PADT was associated with decreased risk of all-cause mortality but not prostate-cancer–specific mortality. PADT was associated with decreased risk of all-cause mortality only among the subgroup of men with a high risk of cancer progression (HR, 0.88; 95% CI, 0.78 to 0.97). Conclusion We found no mortality benefit from PADT compared with no PADT for most men with clinically localized prostate cancer who did not receive curative intent therapy. Men with higher-risk disease may derive a small clinical benefit from PADT. Our study provides the best available contemporary evidence on the lack of survival benefit from PADT for most men with clinically localized prostate cancer.

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