scholarly journals Mixed large cell neuroendocrine carcinoma with squamous cell carcinoma of the rectum: Report of a rare case and review of the literature

2013 ◽  
Vol 4 (12) ◽  
pp. 1076-1079 ◽  
Author(s):  
Konstantinos Vardas ◽  
Georgios Papadimitriou ◽  
Maria Chantziara ◽  
Alexandros Papakonstantinou ◽  
Spiros Drakopoulos
2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Ryusuke Murakami ◽  
Iemasa Kou ◽  
Kenjiro Date ◽  
Hirofumi Nakayama

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is very rare and aggressive. The prognosis is very poor despite multimodal treatment. We report a virgin woman with FIGO stage 4b LCNEC of uterine cervix coexisting with squamous cell carcinoma. An early thirties virgin woman presented with 2-month history of abdominal pain. A chest X-ray showed multiple lung metastatic tumors. A vaginal smear showed malignant cells, and a biopsy specimen had features of LCNEC. The tumor showed trabecular patterns. Tumor cells possessed a moderate amount of cytoplasm, prominent nucleoli, and large nuclei. The tumor cells are stained positive for synaptophysin, chromogranin A, and neuron specific enolase (NSE). The invasive tumor cells in connection with cervical squamous epithelium were focally positive for 34bE12. We made a diagnosis of composite LCNEC and nonkeratinizing squamous cell carcinoma. High-risk HPV test was negative with hybridized captured method 2.


2020 ◽  
pp. 014556132095647
Author(s):  
Sanchun Wang ◽  
Hongyan Fang ◽  
Weifang Tong ◽  
Hongyan Wang ◽  
Bo Teng

Basaloid squamous cell carcinoma and large cell neuroendocrine carcinoma are not common in head and neck, these tumors rarely occur in the larynx but both have highly aggressive clinical behavior and a high mortality rate. The diagnosis is complicated by these tumors’ atypical clinical and pathological features. This case details a coexistence of basaloid squamous cell carcinoma and large cell neuroendocrine carcinoma of a woman in the larynx. The patient underwent endoscopy- and coblation-assisted transoral microsurgery to achieve hyoid horizontal epiglottidectomy and has no recurrence after 12 months of follow-up.


Haigan ◽  
2015 ◽  
Vol 55 (2) ◽  
pp. 89-92 ◽  
Author(s):  
Yuki Tenjin ◽  
Hideshi Uramoto ◽  
Hironori Kobayashi ◽  
Mitsuhiro Matsumoto ◽  
Takaaki Ito ◽  
...  

Author(s):  
Nicholas Armando Rossi ◽  
Rachelle Gietzen ◽  
Lauren Malaya ◽  
Kareem Haroun ◽  
Grant Conner ◽  
...  

Combined large cell neuroendocrine carcinoma (LCNEC) and squamous cell carcinoma (SCC) of the H&N is exceptionally rare. We present the case of combined p16 negative SCC and LCNEC of the oropharynx treated with combination chemotherapy. This is the third reported case of combined neuroendocrine carcinoma and SCC of the oropharynx.


1989 ◽  
Vol 103 (11) ◽  
pp. 1093-1096 ◽  
Author(s):  
C. M. Milroy ◽  
P. J. Robinson ◽  
H. R. Grant

AbstractNeuroendocrine carcinomas are rare neoplasms of the larynx and hypopharynx. Tumours composed of both neuroendocrine and Squamous cell elements are very rare. We report a case of a primary hypopharyngeal carcinoma composed of both squamous cell and large cell neuroendocrine carcinoma and discuss the treatment of this patient and management of neuroendocrine carcinomas of the larynx and hypopharynx.


2014 ◽  
Vol 8 (11-12) ◽  
pp. 875 ◽  
Author(s):  
Ci Zou ◽  
Yu Dexin ◽  
Wang Qi ◽  
Zhang Tao ◽  
Xie Dongdong ◽  
...  

We present a case with penile and intramuscular metastases of esophageal squamous cell carcinoma. A 61-year-old male had undergone a total esophagectomy and later developed metastatic nodules of the penis and intramuscular metastasis of the thigh. We believe this is the first report of this rare case. We describe the clinical manifestation and offer therapeutic regimen; we also summarize the relevant literature.


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