scholarly journals Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity

2020 ◽  
Vol 7 (1) ◽  
pp. 75-85
Author(s):  
Christine Woischke ◽  
Peter Jung ◽  
Andreas Jung ◽  
Jörg Kumbrink ◽  
Sibylle Eisenlohr ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Molecular Characterisation ◽  
Carcinoma Of The Colon

scholarly journals Advanced Composite of Large Cell Neuroendocrine Carcinoma and Squamous Cell Carcinoma: A Case Report of Uterine Cervical Cancer in a Virgin Woman

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Ryusuke Murakami ◽  
Iemasa Kou ◽  
Kenjiro Date ◽  
Hirofumi Nakayama
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Neuron Specific Enolase ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Hpv Test

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is very rare and aggressive. The prognosis is very poor despite multimodal treatment. We report a virgin woman with FIGO stage 4b LCNEC of uterine cervix coexisting with squamous cell carcinoma. An early thirties virgin woman presented with 2-month history of abdominal pain. A chest X-ray showed multiple lung metastatic tumors. A vaginal smear showed malignant cells, and a biopsy specimen had features of LCNEC. The tumor showed trabecular patterns. Tumor cells possessed a moderate amount of cytoplasm, prominent nucleoli, and large nuclei. The tumor cells are stained positive for synaptophysin, chromogranin A, and neuron specific enolase (NSE). The invasive tumor cells in connection with cervical squamous epithelium were focally positive for 34bE12. We made a diagnosis of composite LCNEC and nonkeratinizing squamous cell carcinoma. High-risk HPV test was negative with hybridized captured method 2.

scholarly journals Coexistence of Basaloid Squamous Cell Carcinoma and Large Cell Neuroendocrine Carcinoma in the Larynx: A Case Report and Literature Review

2020 ◽  
pp. 014556132095647
Author(s):  
Sanchun Wang ◽  
Hongyan Fang ◽  
Weifang Tong ◽  
Hongyan Wang ◽  
Bo Teng
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Basaloid Squamous Cell Carcinoma ◽  
Transoral Microsurgery ◽  
Basaloid Squamous

Basaloid squamous cell carcinoma and large cell neuroendocrine carcinoma are not common in head and neck, these tumors rarely occur in the larynx but both have highly aggressive clinical behavior and a high mortality rate. The diagnosis is complicated by these tumors’ atypical clinical and pathological features. This case details a coexistence of basaloid squamous cell carcinoma and large cell neuroendocrine carcinoma of a woman in the larynx. The patient underwent endoscopy- and coblation-assisted transoral microsurgery to achieve hyoid horizontal epiglottidectomy and has no recurrence after 12 months of follow-up.

scholarly journals Combined Large Cell Neuroendocrine Carcinoma with Both Adenocarcinoma and Squamous Cell Carcinoma

Haigan ◽  
2015 ◽  
Vol 55 (2) ◽  
pp. 89-92 ◽  
Author(s):  
Yuki Tenjin ◽  
Hideshi Uramoto ◽  
Hironori Kobayashi ◽  
Mitsuhiro Matsumoto ◽  
Takaaki Ito ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma

scholarly journals Combined Large Cell Neuroendocrine Carcinoma and Squamous Cell Carcinoma of the Oropharynx: A Collision Course of Tumors

2021 ◽  
Author(s):  
Nicholas Armando Rossi ◽  
Rachelle Gietzen ◽  
Lauren Malaya ◽  
Kareem Haroun ◽  
Grant Conner ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Combination Chemotherapy ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
The Third

Combined large cell neuroendocrine carcinoma (LCNEC) and squamous cell carcinoma (SCC) of the H&N is exceptionally rare. We present the case of combined p16 negative SCC and LCNEC of the oropharynx treated with combination chemotherapy. This is the third reported case of combined neuroendocrine carcinoma and SCC of the oropharynx.

Primary composite squamous cell carcinoma and large cell neuroendocrine carcinoma of the hypopharynx

1989 ◽  
Vol 103 (11) ◽  
pp. 1093-1096 ◽  
Author(s):  
C. M. Milroy ◽  
P. J. Robinson ◽  
H. R. Grant
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Squamous Cell ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Hypopharyngeal Carcinoma ◽  
Neuroendocrine Carcinomas

AbstractNeuroendocrine carcinomas are rare neoplasms of the larynx and hypopharynx. Tumours composed of both neuroendocrine and Squamous cell elements are very rare. We report a case of a primary hypopharyngeal carcinoma composed of both squamous cell and large cell neuroendocrine carcinoma and discuss the treatment of this patient and management of neuroendocrine carcinomas of the larynx and hypopharynx.

scholarly journals Adenosquamous Carcinoma of the Colon

2018 ◽  
Vol 11 (3) ◽  
pp. 791-796 ◽  
Author(s):  
Tagore Sunkara ◽  
Megan E Caughey ◽  
Priyanka Makkar ◽  
Febin John ◽  
Vinaya Gaduputi
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenosquamous Carcinoma ◽  
Colorectal Cancers ◽  
Men And Women ◽  
Carcinoma Of The Colon ◽  
The Third

Overall, colorectal cancer is the third most commonly diagnosed cancer in both men and women, meaning that it is one of the more widely recognized preventable cancers. Instances of colorectal malignancies though are overwhelmingly attributable to adenocarcinoma. Colorectal cancers with components of squamous cell carcinoma represent a statistical anomaly. Here, we present the case of a 50-year-old male, who complained of abdominal pain and weight loss over a 3-month period of time. Biopsies from a colonoscopy ultimately revealed that this patient’s colon cancer consisted of both adenocarcinoma and squamous cell carcinoma, representing a truly exceptional pathology finding in a patient diagnosed with a colorectal cancer.

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