A randomized, placebo-controlled trial evaluating changes in peripheral neuropathy and quality of life by using low-frequency electrostimulation on breast cancer patients treated with chemotherapy

Purpose Taxane-induced peripheral neuropathy (TIPN) is a common and bothersome toxicity. This study aimed to determine the incidence and severity of TIPN in patients with breast cancer and to investigate the relationship between TIPN and quality of life. Methods A total of 82 breast cancer patients with TIPN symptoms were included in this study. The criteria of National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE v4.03) and the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30, version 3.0) were used to evaluate grading of sensory neuropathy and quality of life, respectively. Analysis of the data was done by IBM SPSS statistics version 23. Results A total of 346 patients received taxane-based chemotherapy and 82 patients (23.7%) experience TIPN. The mean (SD) global health status/quality of life, physical functioning, role functioning, and pain subscales were 60.63 (5.26), 80.64 (9.05), 81.77 (10.41), and 43.88 (11.27), respectively. There were significant negative correlations between global health status/quality of life, physical functioning, and role functioning subscales with the grade of neuropathy (r = −0.33, −0.80, and −0.61, respectively) and positive correlation between pain subscale and the grade of neuropathy (r = 0.70). Conclusion This study shows a clear association between TIPN and worsened quality of life. These findings emphasize on detecting and management of TIPN in an effort to improve the quality of life of breast cancer patients.

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PD04-06: A Randomised Controlled Trial of Quality of Life and Fatigue after Support Group Intervention in Primary Breast Cancer Patients.

10.1158/0008-5472.sabcs11-pd04-06 ◽

2011 ◽

Author(s):

H Granstam Björneklett ◽

C Lindemalm ◽

M-L Ojutkangas ◽

A Berglund ◽

H Letocha ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Randomised Controlled Trial ◽

Cancer Patients ◽

Support Group ◽

Group Intervention ◽

Controlled Trial ◽

Breast Cancer Patients ◽

Randomised Controlled

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A Randomized, Placebo-Controlled Trial Evaluating Changes in Peripheral Neuropathy and Quality of Life by Using Low-Frequency Electrostimulation on Breast Cancer Patients Treated With Chemotherapy

Integrative Cancer Therapies ◽

10.1177/1534735420925519 ◽

2020 ◽

Vol 19 ◽

pp. 153473542092551

Author(s):

Si-Yeon Song ◽

Ji-Hye Park ◽

Jin Sun Lee ◽

Je Ryong Kim ◽

Eun Hee Sohn ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Peripheral Neuropathy ◽

Rating Scale ◽

Controlled Trial ◽

Low Frequency ◽

Pharmacological Intervention ◽

European Organization ◽

Eortc Qlq

Background: This study examined the effect of a portable low-frequency electrostimulation (ES) device on patients diagnosed with chemotherapy-induced peripheral neuropathy (CIPN) immediately after chemotherapy for breast cancer. Methods: A single-center, randomized, placebo-controlled trial was conducted. A total of 72 patients newly diagnosed with CIPN were enrolled and randomly placed into the ES (n = 36) or the sham ES group (SES; n = 36). Duloxetine or pregabalin was prescribed to all participants from the initial assessment. The devices for 14 days, at least twice a day, for at least 120 minutes. The primary outcomes were the overall intensities of the CIPN symptoms as assessed using Numerical Rating Scale (NRS). Secondary outcomes included Total Neuropathy Score (TNS), European Organization for Research and Treatment of Cancer Quality of Life (EORTC-QLQ), Chemotherapy-Induced Peripheral Neuropathy 20 (CIPN20), Functional Assessment of Cancer Therapy-Breast (FACT-B), and Instrument on Pattern Identification and Evaluation for CIPN (IPIE-CIPN). Results: No differences in NRS scores were found between the patients in the ES and the SES group ( P = 0.267). Patients in both groups showed significantly reduced CIPN intensities (ES P < .001; SES P < .001). No significant differences between the groups were found in TNS, EORTC-QLQ, CIPN20, and FACT-B. The general symptoms of CIPN diagnosed as cold arthralgia showed significance only in the ES group ( P = .006). Conclusion: Compared with a placebo, the effectiveness of the low-frequency ES device with pharmacological intervention was not significantly different, but a therapeutic effect was possible.

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Optimizing expectations to prevent side effects and enhance quality of life in breast cancer patients undergoing endocrine therapy: study protocol of a randomized controlled trial

BMC Cancer ◽

10.1186/1471-2407-13-426 ◽

2013 ◽

Vol 13 (1) ◽

Cited By ~ 30

Author(s):

Pia von Blanckenburg ◽

Franziska Schuricht ◽

Ute-Susann Albert ◽

Winfried Rief ◽

Yvonne Nestoriuc

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Randomized Controlled Trial ◽

Side Effects ◽

Cancer Patients ◽

Endocrine Therapy ◽

Controlled Trial ◽

Breast Cancer Patients ◽

Randomized Controlled

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Effects of yoga program on quality of life and affect in early breast cancer patients undergoing adjuvant radiotherapy: A randomized controlled trial

Complementary Therapies in Medicine ◽

10.1016/j.ctim.2009.06.004 ◽

2009 ◽

Vol 17 (5-6) ◽

pp. 274-280 ◽

Cited By ~ 82

Author(s):

H.S. Vadiraja ◽

M. Raghavendra Rao ◽

Raghuram Nagarathna ◽

H.R. Nagendra ◽

M. Rekha ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Randomized Controlled Trial ◽

Cancer Patients ◽

Early Breast Cancer ◽

Adjuvant Radiotherapy ◽

Controlled Trial ◽

Breast Cancer Patients ◽

Randomized Controlled

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TANGO: effect of tango Argentino on cancer-associated fatigue in breast cancer patients—study protocol for a randomized controlled trial

Trials ◽

10.1186/s13063-021-05869-3 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Shiao Li Oei ◽

Thomas Rieser ◽

Sarah Becker ◽

Jessica Groß ◽

Harald Matthes ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Sleep Quality ◽

Cancer Patients ◽

Negative Impact ◽

Controlled Trial ◽

Breast Cancer Patients ◽

Argentine Tango ◽

Patient Reported

Abstract Background The majority of breast cancer patients suffer from persistent impairments after completion of their primary oncological therapy. Cancer-related fatigue (CRF) in particular is a multidimensional syndrome having a profound negative impact on the quality of life. To counter CRF symptoms, physical activities are suggested as first-line interventions, mind-body therapies have been shown to be effective, and music therapy can also reduce anxiety and stress in breast cancer patients. Tango therapy that combines various elements can have an impact on physical, psychological, and cognitive abilities and could therefore have a beneficial effect on breast cancer patients. The purpose of this study is to investigate whether a 6-week tango module is suited as a therapeutic approach for people after primary breast cancer therapy to favorably influence their quality of life, especially CRF levels. Methods Sixty patients with a diagnosis for stage I–III breast cancer 12–48 months before enrollment and with CRF (age > 18) will be recruited and randomized 1:1 to a tango or a waiting-list group. Movement concepts using elements of Argentine tango (self-awareness, musical and spatial perception, self-perception, playfulness, shared experience) will be examined with the participants during six consecutive weekly 1-h tango sessions. The primary outcome will be the improvement of CRF (German version of the Cancer Fatigue Scale), and the secondary outcomes will be the improvement in sleep quality (Pittsburgh Sleep Quality Index) and quality of life (EORTC-QLQ-C30). Patient-reported outcomes will be measured at baseline and 6 weeks later; follow-up will be performed 6, 12, and 24 months after baseline. An evaluation will be performed by means of descriptive data analyses. Discussion Argentine tango, as a music-based movement therapy, can influence different skills and may improve several outcomes. The therapeutic use of Argentine tango in the care of breast cancer patients has not yet been reported. It is anticipated that participants receiving the tango module will have improved CRF, sleep, and quality of life scores compared to a waitlist control. Trial registration German Clinical Trials Registry (DRKS) DRKS00021601. Retrospectively registered on 21 August 2020

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Adherence to yoga practice improves symptom control and quality of life in breast cancer patients undergoing conventional treatment.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e11511 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e11511-e11511

Author(s):

Rao M. Raghavendra ◽

Kodaganur Srinivasachar Gopinath ◽

B S Srinath ◽

Shekhar Patil ◽

P Shashidhara ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Patients ◽

Controlled Trial ◽

Symptom Control ◽

Cancer Type ◽

Breast Cancer Patients ◽

Life Outcomes ◽

Quality Of Life Outcomes

e11511 Background: Adherence plays an important role in success of mind body interventions such as yoga. In this study we evaluated the effects of adherence to yoga intervention on psychological and quality of life outcomes. Methods: Adherence to yoga program was assessed in a randomized controlled trial comparing yoga (n=45) vs. supportive therapy in breast cancer patients with stage II and III disease undergoing primary surgery followed by adjuvant radiotherapy and chemotherapy. Subjects were assessed for self reported symptoms and affective states using symptom checklist, Spielberger’s State Trait Anxiety, Becks Depression Inventory and Functional Living Index in cancer for Quality of life following surgery and during radiotherapy and chemotherapy. Adherence was categorized based on number of sessions of yoga practiced at home per week [regular (>5 sessions), not so regular (3-5 sessions), occasionally (upto 2 sessions)].Multiple hierarchical regression analysis was used to examine the variance in the above outcomes explained by independent prognostic variables (age group, clinical stage of cancer, type of surgery, respective baseline psychological outcomes and regularity of practice) in yoga group alone. Model B includes these four variables plus regularity of practice. Results: Regularity of practice emerged as a secondary predictor for symptom severity following surgery (β= 0.38, p=0.007) and primary predictor for depression (β= 0.37, p=0.05) and severity of symptoms (β= 0.42, p=0.04) during radiotherapy and depression(β= 0.35, p=0.05), severity of symptoms (β= 0.45, p=0.03), anxiety trait(β= 0.40, p=0.03) and quality of life (β= -0.61, p=0.001) during chemotherapy. Conclusions: Adherence to mind body interventions such as yoga improves psychological and quality of life outcomes in breast cancer patients undergoing conventional cancer treatment.

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