The phosphodiesterase 4 inhibitor roflumilast augments the Th17-promoting capability of dendritic cells by enhancing IL-23 production, and impairs their T cell stimulatory activity due to elevated IL-10

2016 ◽  
Vol 35 ◽  
pp. 174-184 ◽  
Author(s):  
Matthias Bros ◽  
Evelyn Montermann ◽  
Anna Cholaszczyńska ◽  
Angelika B. Reske-Kunz
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Phosphodiesterase 4 ◽  
Stimulatory Activity ◽  
Phosphodiesterase 4 Inhibitor

Two Phenotypically Distinct Subsets of Spleen Dendritic Cells in Rats Exhibit Different Cytokine Production and T Cell Stimulatory Activity

2002 ◽  
Vol 169 (5) ◽  
pp. 2284-2291 ◽  
Author(s):  
Cécile Voisine ◽  
Francois-Xavier Hubert ◽  
Benjamin Trinité ◽  
Michèle Heslan ◽  
Régis Josien
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cytokine Production ◽  
Stimulatory Activity

The phosphodiesterase 4 inhibitor apremilast inhibits Th1 but promotes Th17 responses induced by 6-sulfo LacNAc (slan) dendritic cells

2017 ◽  
Vol 87 (2) ◽  
pp. 110-115 ◽  
Author(s):  
Stephanie Oehrl ◽  
Hridayesh Prakash ◽  
Annette Ebling ◽  
Nina Trenkler ◽  
Priscila Wölbing ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Phosphodiesterase 4 ◽  
Phosphodiesterase 4 Inhibitor

Zeitverlauf und Reversibilität der Gewichtsabnahme unter Roflumilast, einem oralen, selektiven Phosphodiesterase 4 Inhibitor

Pneumologie ◽  
2011 ◽  
Vol 65 (S 01) ◽  
Author(s):  
H Trauth ◽  
H Steffen ◽  
U Gehling ◽  
C Faouzi ◽  
C Vogelmeier ◽  
...  
Keyword(s):  
Phosphodiesterase 4 ◽  
Phosphodiesterase 4 Inhibitor
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