scholarly journals ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons

iScience ◽  
2019 ◽  
Vol 19 ◽  
pp. 448-449
Author(s):  
Zachary Osking ◽  
Jacob I. Ayers ◽  
Ryan Hildebrandt ◽  
Kristen Skruber ◽  
Hilda Brown ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Motor Neurons ◽  
Enhance Neurite Outgrowth

scholarly journals ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons

iScience ◽  
2019 ◽  
Vol 11 ◽  
pp. 294-304 ◽  
Author(s):  
Zachary Osking ◽  
Jacob I. Ayers ◽  
Ryan Hildebrandt ◽  
Kristen Skruber ◽  
Hilda Brown ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Motor Neurons ◽  
Enhance Neurite Outgrowth

Muscle-conditioned media and cAMP promote survival and neurite outgrowth of adult spinal cord motor neurons

2009 ◽  
Vol 220 (2) ◽  
pp. 303-315 ◽  
Author(s):  
Jose V. Montoya G. ◽  
Jhon Jairo Sutachan ◽  
Wai Si Chan ◽  
Alexandra Sideris ◽  
Thomas J.J. Blanck ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neurite Outgrowth ◽  
Motor Neurons ◽  
Conditioned Media ◽  
Adult Spinal Cord

scholarly journals Biomimetic surface delivery of NGF and BDNF to enhance neurite outgrowth

2020 ◽  
Vol 117 (10) ◽  
pp. 3124-3135
Author(s):  
Ana M. Sandoval‐Castellanos ◽  
Frederik Claeyssens ◽  
John W. Haycock
Keyword(s):  
Neurite Outgrowth ◽  
Biomimetic Surface ◽  
Enhance Neurite Outgrowth

Defective neurite outgrowth in aphidicolin/cAMP‐induced motor neurons expressing mutant Cu/Zn superoxide dismutase

2002 ◽  
Vol 20 (6) ◽  
pp. 521-526 ◽  
Author(s):  
Kwang‐Woo Lee ◽  
Hyun‐Jeong Kim ◽  
Jung‐Joon Sung ◽  
Kyung‐Seok Park ◽  
Manho Kim
Keyword(s):  
Superoxide Dismutase ◽  
Neurite Outgrowth ◽  
Motor Neurons

scholarly journals Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

2008 ◽  
Vol 181 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Philip Van Damme ◽  
Annelies Van Hoecke ◽  
Diether Lambrechts ◽  
Peter Vanacker ◽  
Elke Bogaert ◽  
...  
Keyword(s):  
Nervous System ◽  
Neurite Outgrowth ◽  
Neurotrophic Factor ◽  
Neuronal Survival ◽  
Cultured Neurons ◽  
Motor Neuron Degeneration ◽  
Neuron Degeneration ◽  
Protein Levels ◽  
The Central Nervous System ◽  
Enhance Neurite Outgrowth

Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in PGRN were identified in patients with motor neuron degeneration, a condition that is related to FTLD. Most mutations identified in patients with FTLD until now have been null mutations. However, it remains unknown whether PGRN protein levels are reduced in the central nervous system from such patients. The effects of PGRN on neurons also remain to be established. We report that PGRN levels are reduced in the cerebrospinal fluid from FTLD patients carrying a PGRN mutation. We observe that PGRN and GRN E (one of the proteolytic fragments of PGRN) promote neuronal survival and enhance neurite outgrowth in cultured neurons. These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration.

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