Diagnostic distinction of malignant melanoma and benign nevi by a gene expression signature and correlation to clinical outcomes

2017 ◽  
Vol 76 (6) ◽  
pp. AB100
Keyword(s):  
Gene Expression ◽  
Malignant Melanoma ◽  
Clinical Outcomes ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Benign Nevi

Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

2017 ◽  
Vol 26 (7) ◽  
pp. 1107-1113 ◽  
Author(s):  
Jennifer S. Ko ◽  
Balwir Matharoo-Ball ◽  
Steven D. Billings ◽  
Brian J. Thomson ◽  
Jean Y. Tang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Malignant Melanoma ◽  
Clinical Outcomes ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Benign Nevi

Development and validation of a gene expression signature to distinguish malignant melanoma from benign nevi.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 9021-9021
Author(s):  
Colleen Rock ◽  
Loren E Clarke ◽  
M. Bryan Warf ◽  
Darl D Flake ◽  
Anne-Renee Hartman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Malignant Melanoma ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Development And Validation ◽  
Benign Nevi

scholarly journals Clinical validation of a gene expression signature that differentiates benign nevi from malignant melanoma

2015 ◽  
Vol 42 (4) ◽  
pp. 244-252 ◽  
Author(s):  
Loren E. Clarke ◽  
M.B. Warf ◽  
Darl D. Flake ◽  
Anne‐Renee Hartman ◽  
Steven Tahan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Malignant Melanoma ◽  
Gene Expression Signature ◽  
Clinical Validation ◽  
Expression Signature ◽  
Benign Nevi

scholarly journals An independent validation of a gene expression signature to differentiate malignant melanoma from benign melanocytic nevi

Cancer ◽  
2016 ◽  
Vol 123 (4) ◽  
pp. 617-628 ◽  
Author(s):  
Loren E. Clarke ◽  
Darl D. Flake ◽  
Klaus Busam ◽  
Clay Cockerell ◽  
Klaus Helm ◽  
...  
Keyword(s):  
Gene Expression ◽  
Malignant Melanoma ◽  
Gene Expression Signature ◽  
Melanocytic Nevi ◽  
Expression Signature ◽  
Independent Validation ◽  
Benign Melanocytic Nevi

scholarly journals Clinical validity of a gene expression signature in diagnostically uncertain neoplasms

2020 ◽  
Vol 17 (5) ◽  
pp. 361-371
Author(s):  
Loren E Clarke ◽  
Brent Mabey ◽  
Darl D Flake II ◽  
Stephanie Meek ◽  
David S Cassarino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Clinical Outcomes ◽  
Gene Expression Signature ◽  
Test Accuracy ◽  
Test Results ◽  
Clinical Validity ◽  
Diagnostic Uncertainty ◽  
Expression Signature ◽  
High Diagnostic Accuracy ◽  
Diagnostic Certainty

Aim: Evaluate the accuracy of a 23-gene expression signature in differentiating benign nevi from melanoma by comparing test results with clinical outcomes. Materials & methods: Seven dermatopathologists blinded to gene expression test results and clinical outcomes examined 181 lesions to identify diagnostically uncertain cases. Participants independently recorded diagnoses and responses to questions quantifying diagnostic certainty. Test accuracy was determined through comparison with clinical outcomes (sensitivity and percent negative agreement). Results: Overall, 125 cases fulfilled criteria for diagnostic uncertainty (69.1%; 95% CI: 61.8–75.7%). Test sensitivity and percent negative agreement in these cases were 90.4% (95% CI: 79.0–96.8%) and 95.5% (95% CI: 87.3–99.1%), respectively. Conclusion: The 23-gene expression signature has high diagnostic accuracy in diagnostically uncertain cases when evaluated against clinical outcomes.

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