Unruptured Aneurysm of the Sinus of Valsalva Presenting With Right Ventricular Outflow Tract Obstruction, Complete Heart Block, and Protrusion Into Left Ventricular Outflow Tract

Abstract Background: There were no studies on the mechanism of clinical manifestations of straight back syndrome. Our aim was to explore the mechanism of clinical symptoms of straight back syndrome.Methods: From February 2018 to February 2021, we included 4 patients (3 males and 1 female) with straight back syndrome as the experimental group, and 4 normal people matched with sex and BMI as the normal control group. Basic information of patients, laboratory examination, echocardiography in supine and standing position, chest film in positive and lateral position, basic information of control group and echocardiography in supine and standing position were collected. The differences of clinical data between the two groups were compared and analyzed. Results: There were significant differences in left ventricular outflow tract diameter, right ventricular outflow tract diameter and right ventricular outflow tract velocity in the experimental group (their P values were 0.035, 0.011 and 0.015, respectively), but there was no significant difference in left ventricular outflow tract velocity in the standing and supine position (P=0.638). The left ventricular outflow tract diameter, the right ventricular outflow tract diameter and the right ventricular outflow tract velocity in the experimental group were significantly different (P<0.05). The internal diameters of left ventricular outflow tract in upright position, supine position, right ventricular outflow tract, supine position, right ventricular outflow tract were20.50±1.91mm, 18.75±0.96mm;10.00±6.68mm, 15.45±6.06mm;124.25±40.29cm/s and 91.00±28.93cm/s, respectively, in standing position, recumbent position, right ventricular outflow tract, right ventricular outflow tract, supine position, right ventricular outflow tract, supine position, supine position. The velocity of left ventricular outflow tract in upright position was 82.50±2.01 cm/s, and that in supine position was 83.25±2.06 cm/s. There was no significant difference in left ventricular outflow tract velocity in standing and supine position, which may be related to the compression of right ventricular outflow tract.Conclusions: In this study, we got the clinical manifestations of direct-back syndrome patients through comparison of straight back syndrome.

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An unusual case of giant aneurysm of the noncoronary sinus of Valsalva with rupture into the left ventricular outflow tract along with distortion of the mitral valve

Echocardiography ◽

10.1111/echo.14058 ◽

2018 ◽

Vol 35 (9) ◽

pp. 1467-1470

Author(s):

Yuying Tan ◽

Hui Xu ◽

Yongsheng Gao ◽

Chengbin Zhang ◽

Baogang Wang ◽

...

Keyword(s):

Mitral Valve ◽

Unusual Case ◽

Left Ventricular Outflow Tract ◽

Giant Aneurysm ◽

Ventricular Outflow Tract ◽

Left Ventricular ◽

Outflow Tract ◽

Sinus Of Valsalva ◽

Left Ventricular Outflow

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Aortic valve replacement using Konno procedure for prior Yasui procedure

Asian Cardiovascular and Thoracic Annals ◽

10.1177/02184923211052340 ◽

2021 ◽

pp. 021849232110523

Author(s):

Yuki Nakayama ◽

Yusuke Iwata ◽

Takashi Kuwahara ◽

Naoki Kuwabara ◽

Kentaro Omoya ◽

...

Keyword(s):

Ventricular Septal Defect ◽

Septal Defect ◽

Left Ventricular Outflow Tract ◽

Right Ventricular Outflow Tract ◽

Ventricular Outflow Tract ◽

Interrupted Aortic Arch ◽

Left Ventricular ◽

Outflow Tract ◽

Ventricular Septal Defect Closure ◽

Left Ventricular Outflow

A 2-year-old girl underwent conversion to the Konno procedure by removing the Damus–Kaye–Stansel anastomosis after the neonatal Yasui procedure for an interrupted aortic arch with left ventricular outflow tract stenosis. Her postoperative course was uneventful. However, left ventricular outflow tract restenosis occurred due to narrowed ventricular septal defect and moderate neoaortic regurgitation from the old pulmonary valve. The Konno procedure was performed by removing the Damus–Kaye–Stansel anastomosis for left ventricular outflow tract restenosis and neoaortic regurgitation and performing right ventricular outflow tract reconstruction and ventricular septal defect closure. Left ventricular outflow tract restenosis was not observed.

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Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy

BMC Veterinary Research ◽

10.1186/s12917-021-02799-9 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Maureen S. Oldach ◽

Yu Ueda ◽

Eric S. Ontiveros ◽

Samantha L. Fousse ◽

Lance C. Visser ◽

...

Keyword(s):

Hypertrophic Cardiomyopathy ◽

Left Atrial ◽

Left Ventricular Outflow Tract ◽

Maximum Velocity ◽

Right Ventricular Outflow Tract ◽

Ventricular Outflow Tract ◽

Left Ventricular ◽

Outflow Tract ◽

Left Ventricular Outflow ◽

Fractional Shortening

Abstract Background Prior studies have suggested that pimobendan is associated with several positive effects in cats, including improved survival in cats with congestive heart failure and improved left atrial function in research colony cats with hypertrophic cardiomyopathy (HCM) and normal cats. However, there is still a paucity of pharmacodynamic data refuting or supporting the use of pimobendan in a clinical cat population. This clinical trial aimed to evaluate the pharmacodynamic effects and tolerability of a single dose of pimobendan in cats with HCM. Echocardiograms and Doppler-derived systolic blood pressures were performed in 21 client-owned cats with subclinical HCM at baseline and 90-min after oral administration of 1.25 mg of pimobendan (Vetmedin). Seven additional cats were evaluated post-placebo administration to account for intra-day variability. Results Heart rate, systolic blood pressure, and murmur grade were not significantly different between baseline and post-pimobendan evaluations. Left auricular blood flow velocity, left atrial size, and left ventricular fractional shortening were not significantly different between baseline and post-pimobendan evaluations. Mean (± standard deviation) tissue Doppler peak systolic velocity of the mitral annulus was significantly higher following pimobendan (7.4 cm/s ± 1.5 vs 8.5 ± 1.6; p = 0.02). Median (min, max) left-ventricular outflow tract maximum velocity was significantly higher following pimobendan [1.9 m/sec (1.5, 3.4) vs 2.6 m/sec (2.0, 4.0); p = 0.01]. Mean right-ventricular outflow tract maximum velocity was also significantly higher following pimobendan (1.5 m/s ± 0.51 vs 2.0 ± 0.53; p = 0.004). Mean left atrial fractional shortening was significantly higher following pimobendan (28% ± 6 vs 32% ± 7; p = 0.02). No adverse events were observed following pimobendan administration. Right ventricular outflow tract velocity was significantly higher following placebo in control cats (1.02 ± 0.21 versus 1.31 ± 0.31; p = 0.01). No other significant differences were detected. Conclusions In client-owned cats with HCM, pimobendan acutely increased left atrial function and mildly increased left ventricular systolic function. Left ventricular outflow tract velocity was increased after pimobendan. Pimobendan was well tolerated in the acute setting in cats with HCM. The findings of this prospective, acute-dosing study confirm previous findings in research animals and retrospective analyses and suggest that chronic dosing studies are safe and warranted.

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