scholarly journals TCT-360 Impact of Tissue Protrusion Assessed by Optical Coherence Tomography on Early Stent Thrombosis in Patients with ST Elevation Myocardial Infarction

2015 ◽  
Vol 66 (15) ◽  
pp. B146
Author(s):  
Yasushi Ino ◽  
Takashi Kubo ◽  
Yoshiki Matsuo ◽  
Hironori Kitabata ◽  
Yasutsugu Shiono ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Optical Coherence Tomography ◽  
Stent Thrombosis ◽  
St Elevation Myocardial Infarction ◽  
Optical Coherence ◽  
St Elevation

scholarly journals Identification of anatomic risk factors for acute coronary events by optical coherence tomography in patients with myocardial infarction and residual nonflow limiting lesions: rationale and design of the PECTUS-obs study

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e048994
Author(s):  
Jan-Quinten Mol ◽  
Anouar Belkacemi ◽  
Rick HJA Volleberg ◽  
Martijn Meuwissen ◽  
Alexey V Protopopov ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Optical Coherence Tomography ◽  
Target Lesion ◽  
St Elevation Myocardial Infarction ◽  
Optical Coherence ◽  
Target Vessel ◽  
Plaque Vulnerability ◽  
St Elevation ◽  
Oct Imaging

IntroductionIn patients with myocardial infarction, the decision to treat a nonculprit lesion is generally based on its physiological significance. However, deferral of revascularisation based on nonischaemic fractional flow reserve (FFR) values in these patients results in less favourable outcomes compared with patients with stable coronary artery disease, potentially caused by vulnerable nonculprit lesions. Intravascular optical coherence tomography (OCT) imaging allows for in vivo morphological assessment of plaque ‘vulnerability’ and might aid in the detection of FFR-negative lesions at high risk for recurrent events.Methods and analysisThe PECTUS-obs study is an international multicentre prospective observational study that aims to relate OCT-derived vulnerable plaque characteristics of nonflow limiting, nonculprit lesions to clinical outcome in patients with myocardial infarction. A total of 438 patients presenting with myocardial infarction (ST-elevation myocardial infarction and non-ST-elevation myocardial infarction) will undergo OCT-imaging of any FFR-negative nonculprit lesion for detection of plaque vulnerability. The primary study endpoint is a composite of major adverse cardiovascular events (all-cause mortality, nonfatal myocardial infarction or unplanned revascularisation) at 2-year follow-up. Secondary endpoints will be the same composite at 1-year and 5-year follow-up, target vessel failure, target vessel revascularisation, target lesion failure and target lesion revascularisation.Ethics and disseminationThis study has been approved by the Medical Ethics Committee of the region Arnhem-Nijmegen. The results of this study will be disseminated in a main paper and additional papers with subgroup analyses.Trial registration numberNCT03857971.

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