T regulatory cells in allergy: Novel concepts in the pathogenesis, prevention, and treatment of allergic diseases

2005 ◽  
Vol 116 (5) ◽  
pp. 961-968 ◽  
Author(s):  
Mübeccel Akdis ◽  
Kurt Blaser ◽  
Cezmi A. Akdis
Keyword(s):  
T Regulatory Cells ◽  
Allergic Diseases ◽  
Regulatory Cells ◽  
Prevention And Treatment

scholarly journals Influence of polyphenols on allergic immune reactions: mechanisms of action

2012 ◽  
Vol 71 (2) ◽  
pp. 316-321 ◽  
Author(s):  
Thea Magrone ◽  
Emilio Jirillo
Keyword(s):  
Allergic Disease ◽  
T Regulatory Cells ◽  
Allergic Diseases ◽  
Regulatory Cells ◽  
T Helper ◽  
Inhibitory Effects ◽  
T Helper 2 ◽  
Dietary Polyphenols ◽  
Allergic Sensitisation ◽  
Major Target

The increased incidence of allergic disease seems to rely on many factors. Among them, the association between genetic variations of the immune response and environmental pressure by allergens, infectious agents and pollutants should be taken into consideration. In alternative to conventional treatments with corticosteroids and antihistaminics, nutraceuticals have been shown to act on allergic disease either during allergic sensitisation or on consolidated disease. In this review, special emphasis is placed on the effects of dietary polyphenols on three major allergic diseases, namely atopic eczema, food allergy and asthma. Interference of polyphenols with T-helper 2 activation seems to be the main mechanism of their inhibitory effects on allergy development. Moreover, deficits of T-regulatory cells seem to play a pathogenic role in allergic disease and, therefore, these cells may represent a major target of polyphenol activity.

scholarly journals Subsets of T regulatory cells in patients with IgE-mediated allergy

2019 ◽  
pp. 65-71
Author(s):  
G. S. Nikolov ◽  
Y. D. Todorova ◽  
M. H. Nikolova ◽  
R. G. Emilova ◽  
D. M. Hristova ◽  
...  
Keyword(s):  
T Regulatory Cells ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Treg Cells ◽  
Respiratory Allergy ◽  
Relative Importance ◽  
Regulatory Cells ◽  
Absolute Count ◽  
Ige Mediated ◽  
Healthy Persons

Background. It is presently known that several subsets of T-regulatory (Treg) cells, both natural and inducible maintain tolerance to environmental allergens. But the relative importance of distinct phenotypically defined Treg subsets for the clinical manifestations of IgE-mediated allergy has not been elucidated yet.The aim of the study was to investigate the phenotype and number of different Treg subpopulations from patients with IgE-mediated allergy compared with healthy non-allergic individuals.Materials and methods. A group of 20 patients with clinically manifested IgE allergy and a group of 10 healthy no allergic controls were included in the study. Peripheral blood samples were taken after informed consent. Percentage and absolute count (AC) of the following regulatory subsets: naive (CD45RO-FoxP3lo), memory (RO+FoxP3+), effector (Treg eff, RO+FoxP3hi), induced (CD39+CD134+), Thl7/Treg (CD196+FoxP3+CD4Treg); Tr1 (IL-10+FoxP3-), were determined using standard 8-parameter flow cytometry (BD FACSCanto II).Results and discussion. The share and AC of FoxP3+CD4 Treg was significantly decreased in sensitized patients as compared to controls (mean 0,6% vs. 3,3%, p<0.05 and 8,7 vs. 55 cells/μl p<0.001). In addition, a significantly decreased level of Tr1 cells was observed in the patients with allergy, 0,4% vs. 2,1 % in healthy controls (p<0,05) as well for subset of Thl7/Treg (mean 7,7% vs. 28,4% in healthy persons, p<0.01).Conclusion. The significantly decreased number of FoxP3+CD4 Treg as well as periphery induced Tr1 and Thl7/Treg cells in patients with respiratory allergy lead to dysregulation and loss of peripheral immune tolerance, which is the pathophysiological basis for development of widely spread allergic diseases like allergic rhinitis and bronchial asthma.

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