Reduction of Substance P in Nasal Lavage Fluid after Allergen Challenge of Mugwort Allergic Patients during Allergen Immunotherapy

2008 ◽  
Vol 121 (2) ◽  
pp. S125-S125
Author(s):  
R GAWLIK ◽  
B JAWOR ◽  
B ROGALA ◽  
L DUBUSKE
Keyword(s):  
Substance P ◽  
Allergen Immunotherapy ◽  
Allergen Challenge ◽  
Lavage Fluid ◽  
Nasal Lavage ◽  
Nasal Lavage Fluid

scholarly journals Substance P and Hemokinin 1 in Nasal Lavage Fluid of Patients with Chronic Sinusitis and Nasal Polyposis

OTO Open ◽  
2019 ◽  
Vol 3 (3) ◽  
pp. 2473974X1987507
Author(s):  
Ashley Lonergan ◽  
Theoharis Theoharides ◽  
Eirini Tsilioni ◽  
Elie Rebeiz
Keyword(s):  
Substance P ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Medical Center ◽  
Disease Process ◽  
Lavage Fluid ◽  
Nasal Lavage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Nasal Lavage Fluid

This pilot study was undertaken to isolate and quantify substance P (SP) and hemokinin 1 (HK-1) in the nasal lavage fluid of patients with chronic rhinosinusitis with nasal polyps to better elucidate the pathophysiology underlying this inflammatory process, which remains poorly understood. Mucus samples were collected from this introductory cohort of 10 patients diagnosed with chronic rhinosinusitis with nasal polyps at Tufts Medical Center (Boston, Massachusetts). Relative levels of SP and HK-1 were measured with enzyme-linked immunosorbent assay methods. Both inflammatory neuropeptides were found in detectable and comparable amounts in patient samples and in concentrations up to 100-fold those established in past literature. The presence of SP and HK-1 necessitates further investigation into their role in nasal polyposis and the potentiation of the chronic inflammation inherent to chronic rhinosinusitis. Downregulating these peptides could therefore provide novel treatment targets to manage this disease process.

Determination of substance P in human nasal lavage fluid

Neuropeptides ◽  
1996 ◽  
Vol 30 (2) ◽  
pp. 117-124 ◽  
Author(s):  
K-D Schultz ◽  
J Furkert ◽  
A O'Connor ◽  
M Böttcher ◽  
M Schmidt ◽  
...  
Keyword(s):  
Substance P ◽  
Lavage Fluid ◽  
Nasal Lavage ◽  
Nasal Lavage Fluid

Tryptase in nasal lavage fluid after local allergen challenge: Relationship to histamine levels and TAME-esterase activity

Allergy ◽  
1991 ◽  
Vol 46 (6) ◽  
pp. 459-465 ◽  
Author(s):  
S. JULIUSSON ◽  
K. HOLMBERG ◽  
C. R. BAUMGARTEN ◽  
M. OLSSON ◽  
I. ENANDER ◽  
...  
Keyword(s):  
Esterase Activity ◽  
Allergen Challenge ◽  
Lavage Fluid ◽  
Nasal Lavage ◽  
Nasal Lavage Fluid

Tryptase in nasal lavage fluid after local allergen challenge: Relationship to histamine levels and TAME-esterase activity

Allergy ◽  
1991 ◽  
Vol 46 (s11) ◽  
pp. 459-465 ◽  
Author(s):  
S. Juliusson ◽  
K. Holmberg ◽  
C. R. Baumgarten ◽  
M. Olson ◽  
I. Enander ◽  
...  
Keyword(s):  
Esterase Activity ◽  
Allergen Challenge ◽  
Lavage Fluid ◽  
Nasal Lavage ◽  
Nasal Lavage Fluid

Oxatomide attenuates the priming capacity on polymorphonuclear leukocytes of nasal lavage fluid obtained after allergen challenge

1998 ◽  
Vol 59 (6) ◽  
pp. 395-405 ◽  
Author(s):  
Ahmad Kantar ◽  
Nicola Oggiano ◽  
Giovanni V. Coppa ◽  
Orazio Gabrielli ◽  
Pier L. Giorgi ◽  
...  
Keyword(s):  
Polymorphonuclear Leukocytes ◽  
Allergen Challenge ◽  
Lavage Fluid ◽  
Nasal Lavage ◽  
Nasal Lavage Fluid

scholarly journals The Immuno-Modulatory Activities of Pentaherbs Formula on Ovalbumin-Induced Allergic Rhinitis Mice via the Activation of Th1 and Treg Cells and Inhibition of Th2 and Th17 Cells

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 239
Author(s):  
Peiting Li ◽  
Miranda Sin-Man Tsang ◽  
Lea Ling-Yu Kan ◽  
Tianheng Hou ◽  
Sharon Sze-Man Hon ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
T Cell ◽  
Inflammatory Mediators ◽  
Th17 Cells ◽  
Lavage Fluid ◽  
Nasal Lavage ◽  
Nasal Epithelium ◽  
Tnf Α ◽  
Nasal Lavage Fluid ◽  
Sinonasal Mucosa

Allergic rhinitis (AR) is a highly prevalent allergic disease induced by immunoglobulin (Ig) E-mediated hypersensitivity reaction at the nasal epithelium against inhaled allergens. Previous studies have demonstrated that Pentaherbs formula (PHF), a modified herbal formula comprising five herbal medicines (Flos Lonicerae, Herba Menthae, Cortex Phellodendri, Cortex Moutan and Rhizoma Atractylodis), could suppress various immune effector cells to exert anti-inflammatory and anti-allergic effects in allergic asthma and atopic dermatitis. The present study aimed to further determine the anti-inflammatory activities of PHF in an ovalbumin (OVA)-induced AR BALB/c mouse model. Nasal symptoms such as sneezing and nose rubbing were recorded and the serum total IgE and OVA-specific IgG1, as well as interleukin (IL)-4, IL-5, IL-10, IL-13, chemokines CXCL9 CXCL10, and tumor necrosis factor (TNF)-α concentrations in nasal lavage fluid (NALF) were measured during different treatments. Effects of PHF on the expression of inflammatory mediators in the sinonasal mucosa were quantified using real-time QPCR. PHF was found to suppress allergic symptoms, infiltration of inflammatory cells, and hyperplasia of goblet cells in the nasal epithelium of the OVA-induced AR mice. PHF could reduce OVA-specific IgG1 level in serum, and TNF-α and IL-10 in nasal lavage fluid (NALF), significantly up-regulate the splenic regulatory T (Treg) cell level, increase the Type 1 helper T cell (Th1)/Type 2 helper T cell (Th2) ratio, and reduce the Th17 cells (all p < 0.05). PHF could also alleviate in situ inflammation in sinonasal mucosa of OVA-induced AR mice. In conclusion, oral treatment of PHF showed immuno-modulatory activities in the OVA-induced AR mice by regulating the splenic T cell population to suppress the nasal allergy symptoms and modulating inflammatory mediators, implicating that PHF could be a therapeutic strategy for allergic rhinitis.

Sign in / Sign up

Export Citation Format

Share Document