Blocking Antigen Transport To Resident Lymph Node Dendritic Cells Prevents CD4+ T-cell Priming

2011 ◽  
Vol 127 (2) ◽  
pp. AB93-AB93
Author(s):  
J.A. Steinberg ◽  
A. Mahajan ◽  
H.M.A. Simkins ◽  
T.M. Laufer
Keyword(s):  
Dendritic Cells ◽  
Lymph Node ◽  
T Cell ◽  
Cd4 T Cell ◽  
T Cell Priming ◽  
Antigen Transport

scholarly journals BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming

2015 ◽  
Vol 11 (10) ◽  
pp. e1005206 ◽  
Author(s):  
Vishnu Priya Bollampalli ◽  
Lívia Harumi Yamashiro ◽  
Xiaogang Feng ◽  
Damiën Bierschenk ◽  
Yu Gao ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Node ◽  
T Cell ◽  
Skin Infection ◽  
Cd4 T Cell ◽  
Draining Lymph Node ◽  
T Cell Priming

scholarly journals Characterizing the Dynamics of CD4+ T Cell Priming within a Lymph Node

2010 ◽  
Vol 184 (6) ◽  
pp. 2873-2885 ◽  
Author(s):  
Jennifer J. Linderman ◽  
Thomas Riggs ◽  
Manjusha Pande ◽  
Mark Miller ◽  
Simeone Marino ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Cd4 T Cell ◽  
T Cell Priming

scholarly journals Transfer of T Cell Surface Molecules to Dendritic Cells upon CD4+ T Cell Priming Involves Two Distinct Mechanisms

2008 ◽  
Vol 181 (6) ◽  
pp. 3965-3973 ◽  
Author(s):  
Annette Busch ◽  
Thomas Quast ◽  
Sascha Keller ◽  
Waldemar Kolanus ◽  
Percy Knolle ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Surface ◽  
Cd4 T Cell ◽  
Cell Surface Molecules ◽  
Surface Molecules ◽  
T Cell Priming

scholarly journals Protease-activated receptor-2 signalling by tissue factor on dendritic cells suppresses antigen-specific CD4+T-cell priming

Immunology ◽  
2013 ◽  
Vol 139 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Seema Shrivastava ◽  
Liang Ma ◽  
El-Li Tham ◽  
John H. McVey ◽  
Daxin Chen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Tissue Factor ◽  
Cd4 T Cell ◽  
T Cell Priming ◽  
Protease Activated Receptor 2

scholarly journals Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance

2014 ◽  
Vol 211 (6) ◽  
pp. 1153-1166 ◽  
Author(s):  
Juan Dubrot ◽  
Fernanda V. Duraes ◽  
Lambert Potin ◽  
Francesca Capotosti ◽  
Dale Brighouse ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Lymph Node ◽  
T Cell ◽  
Stromal Cells ◽  
Cd4 T Cells ◽  
Cd4 T Cell ◽  
Cell Functions ◽  
Mhcii Expression ◽  
Lymph Node Stromal Cells

Dendritic cells (DCs), and more recently lymph node stromal cells (LNSCs), have been described to tolerize self-reactive CD8+ T cells in LNs. Although LNSCs express MHCII, it is unknown whether they can also impact CD4+ T cell functions. We show that the promoter IV (pIV) of class II transactivator (CIITA), the master regulator of MHCII expression, controls endogenous MHCII expression by LNSCs. Unexpectedly, LNSCs also acquire peptide–MHCII complexes from DCs and induce CD4+ T cell dysfunction by presenting transferred complexes to naive CD4+ T cells and preventing their proliferation and survival. Our data reveals a novel, alternative mechanism where LN-resident stromal cells tolerize CD4+ T cells through the presentation of self-antigens via transferred peptide–MHCII complexes of DC origin.

scholarly journals Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulation

1999 ◽  
Vol 29 (9) ◽  
pp. 2705-2714 ◽  
Author(s):  
Francesca Aloisi ◽  
Francesco Ria ◽  
Sandra Columba-Cabezas ◽  
Henry Hess ◽  
Giuseppe Penna ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
B Cells ◽  
Relative Efficiency ◽  
Cd4 T Cell ◽  
Th2 Cell ◽  
T Cell Priming
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