The Role of Molecular Allergology in Allergen-Specific Immunotherapy Adherence and Patient Quality of Life in A Complex Pollen Area: A Simulation Model

2013 ◽  
Vol 131 (2) ◽  
pp. AB201 ◽  
Author(s):  
Barbara Mascialino ◽  
Lisse-Lotte Hermansson ◽  
Joaquin Sastre
Keyword(s):  
Quality Of Life ◽  
Simulation Model ◽  
Specific Immunotherapy ◽  
Allergen Specific Immunotherapy ◽  
Molecular Allergology

scholarly journals Efektivitas imunoterapi terhadap gejala, temuan nasoendoskopik dan kualitas hidup pasien rinosinusitis alergi

2012 ◽  
Vol 42 (2) ◽  
Author(s):  
Yuwan Pradana ◽  
Teti Madiadipoera ◽  
Melati Sudiro ◽  
Arif Dermawan
Keyword(s):  
Quality Of Life ◽  
Visual Analogue Scale ◽  
Disease Severity ◽  
Analogue Scale ◽  
Specific Immunotherapy ◽  
Drug Intake ◽  
Allergen Specific Immunotherapy ◽  
Nasal Symptoms ◽  
Severity Of The Disease

Background: Rhinosinusitis is one of major health problems which increased the economic burden. With symptoms include nasal congestion, rhinorrhea, facial pain, and sometimes reduced or loss of smell, this condition may impair work productivity and quality of life (QOL). Rhinosinusitis is one of the comorbidity of allergic rhinitis. Allergen specific immunotherapy provides protection against the occurence of allergic symptoms and inflammatory reactions due to allergen exposure, that results in improvement  of QOL of allergic rhinosinusitis patients.   To assess the effectiveness of immunotherapy in the  severity of the disease, nasal symptoms, nasoendoscopic findings, drugs intake, and the QOL in allergic rhinosinusitis patients treated with specific immunotherapy. Methods: A retrospective descriptive study conducted at the Rhinology-Allergy Clinic of ORL-HNS Department, Dr.Hasan Sadikin General Hospital, Bandung, on January - December 2011, towards 25 patients, by anamnesis, severity of the disease using Visual Analogue Scale (VAS), nasal symptoms from Weeke, Davis and Okuda, nasoendoscopic findings from Lund-Kennedy, drug intake score, and QOL assesment using Rhinoconjuctivitis Quality of Life Questionaire. Results: There was a significant correlation (p<0,05) between specific immunotherapy for 1 year observed by reduced disease severity, reduced nasal symptoms, nasoendoscopic findings improvement, reduced drug intake, and increased Quality of Life which shows significant results from 3 months after immunotherapy using Wilcoxon differential test (p<0,001). Conclusion: Immunotherapy for 1 year was significantly reduced disease severity, reduced nasal symptoms, improved nasoendoscopic findings, reduced drug intake, and improvement of QOL in patients with allergic rhinosinusitis began from 3 months after immunotherapy and maintained afterwards. Key words: allergic rhinosinusitis, nasal symptoms, nasoendoscopy, specific immunotherapy, quality of life    Abstrak :  Latar belakang: Rinosinusitis merupakan salah satu masalah kesehatan yang semakin meningkat sehingga menjadi beban besar terhadap perekonomian masyarakat. Dengan gejala berupa hidung tersumbat, rinore, nyeri pada wajah dan dapat disertai berkurang atau hilangnya penciuman, kondisi ini dapat menurunkan produktivitas kerja dan kualitas hidup. Rinosinusitis merupakan salah satu komorbiditas dari rinitis alergi. Imunoterapi alergen spesifik bertujuan untuk memberikan perlindungan terhadap timbulnya gejala alergi dan reaksi inflamasi akibat pajanan alergen, sehingga dapat meningkatkan kualitas hidup pasien rinosinusitis. Tujuan: Membuktikan efektivitas imunoterapi terhadap tingkat beratnya penyakit, gejala hidung, nasoendoskopi, penggunaan obat dan kualitas hidup pasien rinosinusitis alergi yang diberikan pengobatan imunoterapi selama 3, 6, dan 12 bulan. Metode: Dilakukan penelitian deskriptif retrospektif, di Poliklinik Rinologi Alergi Ilmu Kesehatan THT-KL RSHS Bandung, dalam periode JanuariDesember 2011 pada 25 pasien, menggunakan anamnesis, tingkat berat penyakit berdasarkan Visual Analogue Scale (VAS), gejala hidung  berdasarkan Weeke, Davis dan Okuda, pemeriksaan nasoendoskopi berdasarkan Lund-Kennedy, penggunaan obat dan penilaian kualitas hidup dengan Rhinoconjuctivitis Quality of Life Questionaire. Hasil: Didapatkan hubungan bermakna berdasarkan uji chi-kuadrat-Friedman   antara imunoterapi selama 1 tahun (p<0,05) terhadap penurunan tingkat berat penyakit, penurunan gejala hidung, perbaikan temuan nasoendoskopi, penurunan penggunaan obat, serta peningkatan kualitas hidup. Didapat perbaikan secara bermakna sejak 3 bulan pasca imunoterapi (p<0,001) berdasarkan uji beda Wilcoxon. Kesimpulan: Imunoterapi selama 1 tahun efektif terhadap penurunan tingkat berat penyakit, penurunan gejala hidung, perbaikan temuan nasoendoskopi, penurunan penggunaan obat, serta peningkatan kualitas hidup pada pasien rinosinusitis alergi, dengan perbaikan sejak 3 bulan dan bertahan hingga 1 tahun pasca-imunoterapi. Kata kunci: rinosinusitis alergi, gejala hidung, nasoendoskopi, imunoterapi, kualitas hidup 

Canine atopic dermatitis — the veterinary ‘eczema’ nurse

2019 ◽  
Vol 10 (6) ◽  
pp. 296-303
Author(s):  
Sue Paterson
Keyword(s):  
Quality Of Life ◽  
Specific Immunotherapy ◽  
Essential Fatty Acids ◽  
Topical Therapy ◽  
Human Medicine ◽  
Allergen Specific Immunotherapy ◽  
Veterinary Surgeons ◽  
Allergic Skin ◽  
Specialist Nurses

In human medicine many NHS hospitals employ ‘eczema specialist’ nurses. These are nurses with additional training that help individuals diagnosed with eczema to manage their own disease and can provide them with the information and support to improve their quality of life. Veterinary nurses as part of a Vet-led Team also have the opportunity to help their clients in a similar way, by advising owners on the best way to manage their allergic pets. In order to provide that support nurses need a thorough grounding in many of the supplementary therapies that can be prescribed by veterinary surgeons as part of a multi-modal approach to allergic skin disease. Supplementary drugs that can be added into a treatment regimen with foundation drugs such as allergen specific immunotherapy, ciclosporine, glucocorticoids, lokivetmab and oclacitinib include drugs such as antihistamines, essential fatty acids and topical therapy in the form of moisturisers.

scholarly journals Experienceof subcutaneous allergen-specific immunotherapy with «Phostal» in children.

2011 ◽  
Vol 8 (6) ◽  
pp. 28-32
Author(s):  
Natal'ya Viktorovna Shakhova ◽  
V V Gordeev ◽  
V P Tokarev ◽  
T Yu Borisenko ◽  
S S Kharchenko ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Control Group ◽  
Tree Pollen ◽  
Allergen Specific Immunotherapy ◽  
Drug Load ◽  
Initial Stage ◽  
Local Reactions

Background. The purpose of the work is to investigate the effectiveness and safety of the subcutaneous allergenspecific immunotherapy (scIT ) using F ostal at pollinosis children. Methods. 31 patient (19 boys and 12 girls) at the age from 5 to 16 with pollinosis with sensibilization to tree pollen (birch, alder, hazel) allergens were observed. A ll patients were divided into 2 groups. T he first group consisted of 11 children, which were treated with F ostal. T he second group was a control group, consisted of 20 children, no treatment was assigned to them. A ll patients from both groups got the basis pollinosis therapy. Efficiency of the scIT using F ostal was estimated in terms of its influence on the childrens quality of life, clinical symptoms and drug load. Results. Good results demonstrated in terms of increased quality of life indexes were achieved after the initial stage of the scIT using F ostal. C ompared to the control group, the amount of needed drugs was significantly decreased, and the decrease in the severity of clinical symptoms of rhinitis (p=0,001) and conjunctivitis (p=0,002) was observed. During the scIT with the F ostal trees pollen some negligible local reactions were observed in all cases, in 7 of 11 patients marked local reactions appeared. O n the initial stage of the therapy no systemic allergic reaction was observed. Conclusion. On the basis of the results of the study, F ostal could be considered as a highly effective and safe for treatment of pollinosis children. S cIT with the F ostal leads to the improvement of childrens quality of life, decreasing of clinical symptoms severity as well as drug load.

scholarly journals Allergen-specific immunotherapy for local allergic rhinitis: a systematic review and meta-analysis

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
M.P. Hoang ◽  
J. Samuthpongtorn ◽  
W. Chitsuthipakorn ◽  
K. Seresirikachorn ◽  
K. Snidvongs
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Symptom Score ◽  
Observational Studies ◽  
Specific Immunotherapy ◽  
Allergen Specific Immunotherapy ◽  
Local Allergic Rhinitis ◽  
Medication Score ◽  
Disease Specific

Background: Local allergic rhinitis (LAR) is a phenotype of chronic rhinitis exhibiting a local Th2-driven inflammation without positive clinical markers of atopy. Immunomodulatory effects of allergen-specific immunotherapy (AIT) induce allergen-specific tolerance. However, AIT is not well-recognized as a treatment for LAR. Methodology: Systematic search on six electronic databases and registries was performed. Experimental and observational studies of AIT for LAR patients were retrieved. The primary outcomes were symptom score, medication score, combined symptom medication score, and disease-specific quality of life. Secondary outcomes were serum specific(s) IgG4, sIgE, and adverse events. Results: Four double-blind randomized controlled trials (156 patients) from two research units assessed the effects of subcutaneous immunotherapy (SCIT). Compared with placebo, SCIT showed significant reductions in symptom score, medication score, combined symptom medication score, disease-specific quality of life, and an increase in serum sIgG4. There was no significant change in serum sIgE. Likewise, two observational studies (one using SCIT and one using sublingual immunotherapy) improved post-therapeutic symptom score. No studies assessed the effects after discontinuation of treatment. AIT was safe without serious adverse events. Conclusion: AIT has beneficial effects and safe for LAR. Its effects are restricted to studies with short-term follow-up. AIT may be considered in LAR patients.

scholarly journals Pollen allergy and household budget

2011 ◽  
Vol 8 (4) ◽  
pp. 79-83
Author(s):  
M A Mokronosova ◽  
M A Mokronosova
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Specific Immunotherapy ◽  
Birch Pollen ◽  
Pollen Allergy ◽  
Direct Costs ◽  
Middle Part ◽  
Allergen Specific Immunotherapy ◽  
Severity Of The Disease

The prevalence of the allergy to birch pollen is high in the middle part of russian Federation. the symptoms of allergic intermittent rhinitis appears in the first decade and lasted during all life. the severity of the disease is aggravated annually. the economic burden of allergic rhinitis includes direct, indirect and hidden costs. the indirect cost (disability and loss of productivity, hypoallergenic life arrangements) exceeds direct costs many times. allergen specific immunotherapy by pollen allergovaccines is unique kind of pathogenic management. asIt demonstrates significant improvement of the symptoms of rhinitis and asthma, quality of life. one of the main problems is high costs of asIt. economical models used in investigations on asIt cost effectiveness demonstrated lucre in the following 10 years of life after 3 year's course of asIt. In order to achieve high clinical result it is necessary to follow european standard's guidance on specific immunotherapy strictly.

scholarly journals Allergen-specific immunotherapy using pollen allergens in cross-reactive food allergy: what do we know?

2018 ◽  
Vol 15 (6) ◽  
pp. 45-49
Author(s):  
O A Ereshko ◽  
S G Makarova ◽  
L S Namazova-Baranova
Keyword(s):  
Quality Of Life ◽  
Food Allergy ◽  
Specific Immunotherapy ◽  
Pollen Allergens ◽  
Allergen Specific Immunotherapy

Cross-reactive food allergy to plant-based products can lead to a significant increase in morbidity and impairment of quality of life, therefore it is important to analyze the literature data on the effectiveness of conventional and available methods of AIT in these patients.

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