scholarly journals CD4+ and CD8+CD60+CD45RO+IL-4+IFNγ- T Cells Expressing Receptors for Complement Split Product (CSP) C3a, but Not C5a, Are Increased in Blood of Serum IgE+, Compared With Serum IgE- Adults

2018 ◽  
Vol 141 (2) ◽  
pp. AB116
Author(s):  
Lucius DeGregorio ◽  
Timothy D. Morello ◽  
Seto M. Chice ◽  
Maja Nowakowski ◽  
Tehila A. Saadia ◽  
...  
Keyword(s):  
T Cells ◽  
Serum Ige ◽  
Complement Split Product

scholarly journals Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes1✪

2001 ◽  
Vol 194 (9) ◽  
pp. 1349-1360 ◽  
Author(s):  
Maria A. Curotto de Lafaille ◽  
Stephanie Muriglan ◽  
Mary-Jean Sunshine ◽  
Ying Lei ◽  
Nino Kutchukhidze ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Immunoglobulin E ◽  
Effector Memory ◽  
Serum Ige ◽  
Activation Induced Cell Death ◽  
Normal Individuals ◽  
Specific Effector ◽  
Ige Response

A key event in the pathogenesis of allergies is the production of antibodies of the immunoglobulin (Ig)E class. In normal individuals the levels of IgE are tightly regulated, as illustrated by the low serum IgE concentration. In addition, multiple immunizations are usually required to generate detectable IgE responses in normal experimental animals. To define the parameters that regulate IgE production in vivo, we generated mice bearing monoclonal populations of B and T lymphocytes specific for influenza virus hemagglutinin (HA) and chicken ovalbumin (OVA), respectively. A single immunization of the monoclonal mice with the cross-linked OVA-HA antigen led to serum IgE levels that reached 30–200 μg/ml. This unusually high IgE response was prevented by the infusion of regulatory α/β CD4+ T cells belonging to both CD25+ and CD25− subpopulations. The regulation by the infused T cells impeded the development of fully competent OVA-specific effector/memory Th2 lymphocytes without inhibiting the initial proliferative response of T cells or promoting activation-induced cell death. Our results indicate that hyper IgE responses do not occur in normal individuals due to the presence of regulatory T cells, and imply that the induction of regulatory CD4+ T cells could be used for the prevention of atopy.

scholarly journals IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

2009 ◽  
Vol 106 (17) ◽  
pp. 7119-7124 ◽  
Author(s):  
Shlomo Z. Ben-Sasson ◽  
Jane Hu-Li ◽  
Juan Quiel ◽  
Stephane Cauchetaux ◽  
Maya Ratner ◽  
...  
Keyword(s):  
T Cells ◽  
Receptor Antagonist ◽  
Cd4 T Cells ◽  
Th17 Cells ◽  
Serum Ige ◽  
Cognate Antigen ◽  
Memory Cd4 T Cells

IL-1 causes a marked increase in the degree of expansion of naïve and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1β, is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in IL-1R1−/−recipients, IL-1 increases the proportion of cytokine-producing transgenic CD4 T cells, especially IL-17- and IL-4-producing cells, strikingly increases serum IgE levels and serum IgG1 levels. IL-1β enhances antigen-mediated expansion of in vitro primed Th1, Th2, and Th17 cells transferred to IL-1R1−/−recipients. The IL-1 receptor antagonist diminished responses to antigen plus lipopolysaccharide (LPS) by ≈55%. These results indicate that IL-1β signaling in T cells markedly induces robust and durable primary and secondary CD4 responses.

scholarly journals Modulation of IgE Synthesis by IgE-Binding Factors Released by T Cells of Asthmatic Patients with Elevated Serum IgE

1987 ◽  
Vol 31 (3) ◽  
pp. 261-274 ◽  
Author(s):  
Yukiyoshi Yanagihara ◽  
Keiichi Kajiwara ◽  
Mamoru Kiniwa ◽  
Toshiaki Kamisaki ◽  
Yasuo Yui ◽  
...  
Keyword(s):  
T Cells ◽  
Elevated Serum ◽  
Serum Ige ◽  
Asthmatic Patients ◽  
Ige Binding ◽  
Ige Synthesis

scholarly journals Allergic Reactions to Serine Protease-Like Proteins of Staphylococcus aureus

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Nordengrün ◽  
Goran Abdurrahman ◽  
Janina Treffon ◽  
Hannah Wächter ◽  
Barbara C. Kahl ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
T Cells ◽  
Serine Protease ◽  
Allergic Inflammation ◽  
Allergic Airway Inflammation ◽  
Serum Ige ◽  
Airway Infections ◽  
Type 2 Cytokines ◽  
Type 3

In cystic fibrosis (CF) infectious and allergic airway inflammation cause pulmonary exacerbations that destroy the lungs. Staphylococcus aureus is a common long-term colonizer and cause of recurrent airway infections in CF. The pathogen is also associated with respiratory allergy; especially the staphylococcal serine protease-like proteins (Spls) can induce type 2 immune responses in humans and mice. We measured the serum IgE levels specific to 7 proteases of S. aureus by ELISA, targeting 5 Spls (76 CF patients and 46 controls) and the staphopains A and B (16 CF patients and 46 controls). Then we compared cytokine release and phenotype of T cells that had been stimulated with Spls between 5 CF patients and 5 controls. CF patients had strongly increased serum IgE binding to all Spls but not to the staphopains. Compared to healthy controls, their Spl-stimulated T cells released more type 2 cytokines (IL-4, IL-5, IL-13) and more IL-6 with no difference in the secretion of type 1- or type 3 cytokines (IFNγ, IL-17A, IL-17F). IL-10 production was low in CF T cells. The phenotype of the Spl-exposed T cells shifted towards a Th2 or Th17 profile in CF but to a Th1 profile in controls. Sensitization to S. aureus Spls is common in CF. This discovery could explain episodes of allergic inflammation of hitherto unknown causation in CF and extend the diagnostic and therapeutic portfolio.

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