Neo HDL Produced by the Streptococcal Serum Opacity Factor Activity against Human High Density Lipoproteins is Hepatically Removed via Dual Mechanisms

2016 ◽  
Vol 10 (3) ◽  
pp. 679-680
Author(s):  
Perla Rodriguez ◽  
Baiba Gillard ◽  
Corina Rosales ◽  
Antonio Gotto ◽  
Henry Pownall
Keyword(s):  
High Density ◽  
High Density Lipoproteins ◽  
Factor Activity ◽  
Serum Opacity Factor

scholarly journals Apolipoprotein Modulation of Streptococcal Serum Opacity Factor Activity against Human Plasma High-Density Lipoproteins

Biochemistry ◽  
2009 ◽  
Vol 48 (33) ◽  
pp. 8070-8076 ◽  
Author(s):  
Corina Rosales ◽  
Baiba K. Gillard ◽  
Harry S. Courtney ◽  
Francisco Blanco-Vaca ◽  
Henry J. Pownall
Keyword(s):  
Human Plasma ◽  
High Density ◽  
High Density Lipoproteins ◽  
Factor Activity ◽  
Serum Opacity Factor ◽  
Plasma High Density

scholarly journals The Structure and Function of Serum Opacity Factor: A Unique Streptococcal Virulence Determinant That Targets High-Density Lipoproteins

2010 ◽  
Vol 2010 ◽  
pp. 1-16 ◽  
Author(s):  
Harry S. Courtney ◽  
Henry J. Pownall
Keyword(s):  
Lipid Vesicles ◽  
Structure And Function ◽  
High Density ◽  
Host Cells ◽  
High Density Lipoproteins ◽  
Multifunctional Protein ◽  
Virulence Determinant ◽  
Serum Opacity Factor ◽  
Animal Pathogens ◽  
And Function

Serum opacity factor (SOF) is a virulence determinant expressed by a variety of streptococcal and staphylococcal species including both human and animal pathogens. SOF derives its name from its ability to opacify serum where it targets and disrupts the structure of high-density lipoproteins resulting in formation of large lipid vesicles that cause the serum to become cloudy. SOF is a multifunctional protein and in addition to its opacification activity, it binds to a number of host proteins that mediate adhesion of streptococci to host cells, and it plays a role in resistance to phagocytosis in human blood. This article will provide an overview of the structure and function of SOF, its role in the pathogenesis of streptococcal infections, its vaccine potential, its prevalence and distribution in bacteria, and the molecular mechanism whereby SOF opacifies serum and how an understanding of this mechanism may lead to therapies for reducing high-cholesterol concentrations in blood, a major risk factor for cardiovascular disease.

scholarly journals Disruption of Human Plasma High-Density Lipoproteins by Streptococcal Serum Opacity Factor Requires Labile Apolipoprotein A-I†

Biochemistry ◽  
2009 ◽  
Vol 48 (7) ◽  
pp. 1481-1487 ◽  
Author(s):  
Mikyung Han ◽  
Baiba K. Gillard ◽  
Harry S. Courtney ◽  
Kathryn Ward ◽  
Corina Rosales ◽  
...  
Keyword(s):  
Human Plasma ◽  
High Density ◽  
High Density Lipoproteins ◽  
Apolipoprotein A ◽  
Serum Opacity Factor ◽  
Plasma High Density
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