scholarly journals Parental immigration and offspring post-traumatic stress disorder: A nationwide population-based register study

2019 ◽  
Vol 249 ◽  
pp. 294-300 ◽  
Author(s):  
Sanju Silwal ◽  
Venla Lehti ◽  
Roshan Chudal ◽  
Auli Suominen ◽  
Lars Lien ◽  
...  
2021 ◽  
pp. 135245852110583
Author(s):  
Mark Leekoff ◽  
William Culpepper ◽  
Shan Jin ◽  
Terry Lee-Wilk ◽  
Mitchell Wallin

Background: Very little is known regarding the impact of post traumatic stress disorder (PTSD) on the course of multiple sclerosis (MS). Objectives: To explore the impact of pre-existing PTSD on MS relapses, magnetic resonance imaging (MRI) activity, and disability in a large population-based cohort. Methods: Military Veterans with MS and PTSD prior to symptom onset (MSPTSD, n = 96) were identified using the Department of Veterans Affairs MS databases. MSPTSD cases were matched to MS controls without PTSD ( n = 95). Number of relapses, number of new T2 lesions and new gadolinium lesions on brain MRI, and neurological disability were abstracted between 2015 and 2019. Results: The mean annualized relapse rate was greater in the MSPTSD group versus controls (0.23 vs 0.06, respectively; p < 0.05), as was the annualized mean number of new T2 and gadolinium-enhancing lesions on brain MRI (0.52 vs 0.16 and 0.29 vs 0.08, respectively; p < 0.05). Disability accrual (time to Disability Status Scale 6.0) was more rapid (23.7 vs 29.5 years, p < 0.05) in relapsing MS patients with PTSD. Conclusion: Patients with MSPTSD have higher disease activity and reach disability endpoints more rapidly than controls. This is the first study to show PTSD as a potentially modifiable risk factor for MS relapses, MRI activity, and disability.


2019 ◽  
Vol 22 (3) ◽  
pp. 634-638 ◽  
Author(s):  
Alessandro Rodolico ◽  
Noemi Vaccino ◽  
Maria C. Riso ◽  
Carmen Concerto ◽  
Eugenio Aguglia ◽  
...  

2020 ◽  
Vol 263 ◽  
pp. 715-721 ◽  
Author(s):  
Márcio Souto de Castro Longo ◽  
Liliane Maria Pereira Vilete ◽  
Ivan Figueira ◽  
Maria Inês Quintana ◽  
Marcelo Feijó Mello ◽  
...  

2013 ◽  
Vol 14 (3) ◽  
pp. 425-435 ◽  
Author(s):  
Suzanne Barker-Collo ◽  
Alice Theadom ◽  
Shanthi Ameratunga ◽  
Kelly Jones ◽  
Amy Jones ◽  
...  

Objective: Experiencing a traumatic brain injury (TBI) may increase the risk of post-traumatic stress disorder (PTSD); however, this has not been examined in a population-based context. This study examined prevalence and predictors (demographic and injury related) of PTSD 1 year after TBI in a population-based sample.Method: A population-based TBI incidence and outcomes study was conducted in Hamilton and Waikato Districts of New Zealand over 12 months (February 2011–March 2012) with follow-up at 1 year. The relationship of baseline demographic and TBI characteristics to PTSD (Post-traumatic Diagnostic Scale; PDS) was examined in 431 adults (>15 years old) 1 year post-TBI.Results: On average, participants reported three PTSD symptoms, with heightened arousal being the most commonly reported. Nearly 18% of participants met criteria for PTSD. These participants were significantly more likely to report pre-TBI history of depression/anxiety, and to have drugs implicated in the injury. Regression indicated that female gender, increased loss of consciousness (LOC) and intentional injury predicted PTSD severity (R2 = .109, F[6, 294] = 6.007, p < .001) and number of symptoms (R2 = .098, F[3, 297] = 4.562, p < .001).Conclusion: PTSD occurred as a long-term sequela in 18% of participants after TBI, with increased PTSD severity and greater number of symptoms associated with female gender, longer LOC and intentional injury. These findings have implications for identification and targeting of assessment and intervention resources towards those at greatest risk of PTSD following TBI.


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