O1-05-04: Brain atrophy: A risk factor for cognitive decline only when white matter lesions are present? The somatotrophics, memory and aging trial (SMART)-MR study

2008 ◽  
Vol 4 ◽  
pp. T118-T118
Author(s):  
Majon Muller ◽  
Auke P.A. Appelman ◽  
Yolanda van der Graaf ◽  
Willem P.Th.M. Mali ◽  
Mirjam I. Geerlings
Keyword(s):  
Risk Factor ◽  
White Matter ◽  
Cognitive Decline ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Mr Study

IC-P1-040: Brain atrophy: A risk factor for cognitive decline only when white matter lesions are present? The SMART-MR study

2008 ◽  
Vol 4 ◽  
pp. T25-T25
Author(s):  
Majon Muller ◽  
Auke P.A. Appelman ◽  
Yolanda van der Graaf ◽  
Willem P. Th M. Mali ◽  
Mirjam I. Geerlings
Keyword(s):  
Risk Factor ◽  
White Matter ◽  
Cognitive Decline ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Mr Study

Angiotensin-Converting Enzyme and Progression of White Matter Lesions and Brain Atrophy – The SMART-MR Study

2012 ◽  
Vol 29 (1) ◽  
pp. 39-49 ◽  
Author(s):  
Hadassa M. Jochemsen ◽  
Mirjam I. Geerlings ◽  
Anne M. Grool ◽  
Koen L. Vincken ◽  
Willem PTM. Mali ◽  
...  
Keyword(s):  
White Matter ◽  
Angiotensin Converting Enzyme ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Converting Enzyme ◽  
Mr Study

scholarly journals Extracellular vesicle protein levels are related to brain atrophy and cerebral white matter lesions in patients with manifest vascular disease: the SMART-MR study

BMJ Open ◽  
2014 ◽  
Vol 4 (1) ◽  
pp. e003824 ◽  
Author(s):  
Danny A Kanhai ◽  
Dominique P V de Kleijn ◽  
L Jaap Kappelle ◽  
Cuno S P M Uiterwaal ◽  
Yolanda van der Graaf ◽  
...  
Keyword(s):  
White Matter ◽  
Vascular Disease ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Extracellular Vesicle ◽  
Cerebral White Matter ◽  
Protein Levels ◽  
Cerebral White Matter Lesions ◽  
Vesicle Protein ◽  
Mr Study

scholarly journals Total Cerebral Blood Flow, White Matter Lesions and Brain Atrophy: The SMART-MR Study

2007 ◽  
Vol 28 (3) ◽  
pp. 633-639 ◽  
Author(s):  
Auke PA Appelman ◽  
Yolanda van der Graaf ◽  
Koen L Vincken ◽  
Audrey M Tiehuis ◽  
Theo D Witkamp ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Magnetic Resonance ◽  
Brain Atrophy ◽  
Brain Volume ◽  
White Matter Lesions ◽  
Arterial Disease ◽  
Subcortical Brain ◽  
Mr Study

We investigated whether total cerebral blood flow (CBF) was associated with brain atrophy, and whether this relation was modified by white matter lesions (WML). Within the Second Manifestations of ARTerial disease-magnetic resonance (SMART-MR) study, a prospective cohort study among patients with arterial disease, cross-sectional analyses were performed in 828 patients (mean age 58±10 years, 81% male) with quantitative flow, atrophy, and WML measurements on magnetic resonance imaging (MRI). Total CBF was measured with MR angiography and was expressed per 100 mL brain volume. Total brain volume and ventricular volume were divided by intracranial volume to obtain brain parenchymal fraction (BPF) and ventricular fraction (VF). Lower BPF indicates more global brain atrophy, whereas higher VF indicates more subcortical brain atrophy. Mean CBF was 52.0±10.2 mL/min per 100 mL, mean BPF was 79.2±2.9%, and mean VF was 2.03±0.96%. Linear regression analyses showed that lower CBF was associated with more subcortical brain atrophy, after adjusting for age, sex, vascular risk factors, intima-media thickness, and lacunar infarcts, but only in patients with moderate to severe WML (upper quartile of WML): Change in VF per s.d. decrease in CBF 0.18%, 95% CI: 0.02 to 0.34%. Our findings suggest that cerebral hypoperfusion in the presence of WML may be associated with subcortical brain atrophy.

White matter lesions and lacunar infarcts are differentially associated with brain atrophy: The smart-MR study

2009 ◽  
Vol 283 (1-2) ◽  
pp. 308
Author(s):  
A.P. Appelman ◽  
Y. van der Graaf ◽  
A.M. Tiehuis ◽  
K.L. Vincken ◽  
T.D. Witkamp ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Lacunar Infarcts ◽  
Mr Study

O5-02-04: Atherosclerotic disease at different locations and progression of brain atrophy and white matter lesions after 4 years of follow-up: The SMART-MR study

2012 ◽  
Vol 8 (4S_Part_20) ◽  
pp. P732-P732 ◽  
Author(s):  
Erika van der Veen ◽  
Majon Muller ◽  
Anne Grool ◽  
Willem Mali ◽  
Yolanda van der Graaf ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Atherosclerotic Disease ◽  
Mr Study

Homocysteine, white matter lesions and brain atrophy: The smart-MR study

2009 ◽  
Vol 283 (1-2) ◽  
pp. 309
Author(s):  
R. Risselada ◽  
A.P.A. Appelman ◽  
Y. van der Graaf ◽  
K.L. Vincken ◽  
T.D. Witkamp ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Mr Study

White Matter Lesions and Lacunar Infarcts Are Independently and Differently Associated with Brain Atrophy: The SMART-MR Study

2010 ◽  
Vol 29 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Yolanda van der Graaf ◽  
Anne L.M. Vlek ◽  
Theo D. Witkamp ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Atrophy ◽  
White Matter Lesions ◽  
Lacunar Infarcts ◽  
Mr Study

Combined Effect of Cerebral Hypoperfusion and White Matter Lesions on Executive Functioning – The SMART-MR Study

2010 ◽  
Vol 29 (3) ◽  
pp. 240-247 ◽  
Author(s):  
A.P.A. Appelman ◽  
Y. van der Graaf ◽  
K.L. Vincken ◽  
W.P.T.M. Mali ◽  
M.I. Geerlings
Keyword(s):  
White Matter ◽  
Executive Functioning ◽  
White Matter Lesions ◽  
Combined Effect ◽  
Cerebral Hypoperfusion ◽  
Mr Study

Abstract TP181: Serum Eiocosapentaenoic Acids Is Protective Against White Matter Lesions

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Daiki Takano ◽  
Takashi Yamazaki ◽  
Tetsuya Maeda ◽  
Yuichi Satoh ◽  
Yasuko Ikeda ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
White Matter Hyperintensities ◽  
Small Vessel Disease ◽  
White Matter Lesions ◽  
White Matter Hyperintensity ◽  
Partial Regression Coefficient ◽  
The Relationship ◽  
Total Pufa ◽  
Periventricular Hyperintensity

[Introduction] White matter hyperintensities (WMH) are considered manifestation of arteriosclerotic small vessel disease and WMH burden increases risk of ischemic stroke and cognitive decline. There are only a few evidences concerning the relationship between polyunsaturated fatty acids (PUFA) and WMH. The present study was designed to elucidate the association between WMH and PUFA profile including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) in patients with Alzheimer’s disease (AD). [Methods] The present study was based on 119 patients who were diagnosed as having a probable AD according to the NINCDS-ADRDA criteria. Their mean age was 78.3 years old. All subjects underwent neuropsychological evaluation including mini mental state exam (MMSE) and 1.5-Tesla MRI. Fasting blood samples were also collected for the PUFA measurements. We measured the ratio of serum EPA, DHA and AA concentration to the total PUFA concentration. The WMH were evaluated on T2-weight images and classified into periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH). The severity of WMH was graded 5 categories. We investigated the relationship between WMH and PUFA profiles. [Results] The EPA ratio correlated negatively with both PVH (rs=-0.2036, p=0.0264) and DWMH grade (rs=-0.3155, p=0.0005). It remained still significant after adjustment for age, sex, statins use, antithrombotics use, mean blood pressure and presence of hypertension (standardized partial regression coefficient(β)=-0.2516, p=0.0122 for PVH, β=-0.3598, p=0.0001 for DWMH). Neither DHA nor AA ratio correlated with DWMH or PVH grade. The EPA ratio but not DHA or AA ratio correlated positively with total MMSE score (rs=0.2310, p=0.0115). [Conclusions] Our data revealed that the serum EPA was protective against WMH as well as cognitive decline in AD patients. Pathophysiology underlying WMH is complex and the possible mechanisms involved in the pathogenesis of WMH encompass incomplete brain ischemia, increased permeability of blood-brain barrier, and inflammation responses. The relationship between serum EPA and WMH can be partly explained by those anti-ischemic and anti-arteriosclerotic effects of EPA.

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