IC-P-105: IS HIPPOCAMPAL ATROPHY IN HEALTHY ELDERLY INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE RELATED TO AMYLOID DEPOSITION?

Objective:To assess in a longitudinal study whether subjective cognitive decline (SCD) and brain β-amyloid (Aβ) contribute unique information to cognitive decline.Methods:One hundred thirty-six healthy elderly from the Berkeley Aging Cohort Study were followed up for a mean of 4 years. SCD and affective measures were generated from the Geriatric Depression Scale (GDS) with factor analysis on data from a larger set of 347 healthy, nondepressed (GDS <11) elderly individuals. Cognition was summarized with previously validated factor scores. Pittsburgh compound B (PiB)-PET scans were acquired to determine the presence (PiB+) or absence (PiB−) of Aβ pathology. Mixed models were used to assess the independent and interactive effects of SCD, affective features, PiB status, and time on cognition, with adjustment for demographic variables.Results:SCD score demonstrated good construct validity compared to an existing measure of subjective memory and was partially explained by several lower-order measurements. Mixed models revealed that SCD interacted with PiB status to predict change in episodic memory and global cognition over time, with adjustment for affective features. PiB+ individuals with more severe SCD demonstrated the steepest cognitive decline. Worse SCD predicted faster decline in working memory independently of PiB status. No such effects were seen for affective scores when adjusted for SCD.Conclusions:PiB+ individuals with SCD are at greatest risk of cognitive decline. Evidence for amyloid alone is not sufficient to indicate risk of rapid cognitive decline in healthy elderly. Effects of GDS on cognitive decline in nondepressed cohorts may be driven by SCD rather than subsyndromal depression.

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Women Exhibit Lower Global Left Frontal Cortex Connectivity Among Cognitively Unimpaired Elderly Individuals: A Pilot Study from SILCODE

Journal of Alzheimer s Disease ◽

10.3233/jad-210376 ◽

2021 ◽

pp. 1-11

Author(s):

Wenying Du ◽

Changchang Ding ◽

Jiehui Jiang ◽

Ying Han

Keyword(s):

Sex Differences ◽

Cognitive Decline ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Amyloid Β ◽

Subjective Cognitive Decline ◽

Intracranial Volume ◽

Elderly Individuals ◽

Significant Difference ◽

Scale Scores

Background: Mounting evidence suggests that sex differences exist in cognitive reserve (CR) for cognitively unimpaired (CU) elderly individuals. Global left frontal connectivity (gLFC connectivity) is a reliable neural substrate of CR. Objective: The purpose of this study was to explore sex differences in gLFC connectivity among CU elderly individuals. Methods: One hundred thirteen normal controls (NCs) (women = 66) and 132 individuals with subjective cognitive decline (SCD) (women = 92) were recruited from the Sino Longitudinal Study on Cognitive Decline (SILCODE) (data 1). Among them, 88 subjects underwent amyloid-β (Aβ) imaging, including 32 Aβ+ and 56 Aβ–subjects. Forty-six subjects underwent another rs-fMRI examination (data 2) to validate the repeatability of the calculation of gLFC connectivity, which was determined through seed-based functional connectivity between the LFC and voxels throughout the whole brain. Independent-sample t-tests were used to evaluate the sex differences in gLFC connectivity across different subgroups (NC versus SCD, Aβ+ versus Aβ–). Partial correlation analysis was used to calculate the correlations between gLFC connectivity and cognitive assessments. Results: Women exhibited lower gLFC connectivity in both the NC (p = 0.001) and SCD (p = 0.020) subgroups than men. Women also exhibited lower gLFC connectivity in both the Aβ–(p = 0.006) and Aβ+ (p = 0.025) groups. However, the significant difference disappeared in the Aβ+ group when considering the covariates of age, education, total intracranial volume, and APOE4-carrying status. In addition, gLFC connectivity values were negatively correlated with Geriatric Depression Scale scores in the SCD group (r = –0.176, p = 0.047). Conclusion: Women showed lower gLFC connectivity among CU elderly individuals.

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O5-02-01: Brain and cognitive correlates of subjective cognitive decline differ between healthy elderly with and without β-amyloid pathology

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.07.451 ◽

2015 ◽

Vol 11 (7S_Part_7) ◽

pp. P315-P316

Author(s):

Jacob W. Vogel ◽

Monika Varga Doležalová ◽

Renaud La Joie ◽

Shawn Marks ◽

Allison Fero ◽

...

Keyword(s):

Cognitive Decline ◽

Subjective Cognitive Decline ◽

Cognitive Correlates ◽

Amyloid Pathology ◽

Healthy Elderly ◽

Β Amyloid

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Compensatory larger cortical thickness in healthy elderly individuals with electroencephalographic risk for cognitive decline

Neuroreport ◽

10.1097/wnr.0000000000000602 ◽

2016 ◽

Vol 27 (9) ◽

pp. 710-715 ◽

Cited By ~ 2

Author(s):

Susana A. Castro-Chavira ◽

Fernando A. Barrios ◽

Erick H. Pasaye ◽

Graciela C. Alatorre-Cruz ◽

Thalía Fernández

Keyword(s):

Cognitive Decline ◽

Cortical Thickness ◽

Elderly Individuals ◽

Healthy Elderly

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The Frequency of Sleep Medication Use and the Risk of Subjective Cognitive Decline (SCD) or SCD With Functional Difficulties in Elderly Individuals Without Dementia

The Journals of Gerontology Series A ◽

10.1093/gerona/glz269 ◽

2019 ◽

Vol 75 (9) ◽

pp. 1693-1698 ◽

Cited By ~ 1

Author(s):

Joo Eun Lee ◽

Yeong Jun Ju ◽

Ki Hong Chun ◽

Soon Young Lee

Keyword(s):

Cognitive Decline ◽

Medication Use ◽

The Elderly ◽

Subjective Cognitive Decline ◽

Behavioral Risk ◽

Elderly Individuals ◽

Functional Difficulties ◽

Sleep Medication ◽

Sleeping Pills ◽

Frequent Use

Abstract Background The present study investigated whether the frequency of sleep medication use affects subjective cognitive decline (SCD) or SCD with functional difficulties in elderly individuals. Methods The 2018 Korea Community Health Survey data, which consists of national representative and community-based data, was used in this study. A total of 57,050 individuals aged 65 years or older were included in this study. SCD was measured using the Behavioral Risk Factor Surveillance System. A logistic regression analysis was used to analyze the data. Results In total, 16,966 (29.7%) participants had SCD and 3,487 (6.1%) had SCD with functional difficulties. The elderly individuals who took sleep medication more than once a week had higher risks of both SCD and SCD with functional difficulties than those who did not take any sleep medication in a month (SCD: odds ratio [OR] = 1.329, 95% confidence interval [CI] = 1.194–1.480; SCD with functional difficulties: OR = 1.752, 95% CI = 1.491–2.058). Conclusions Frequent sleep medication use was associated with both SCD and SCD with functional difficulties. This study suggests that early detection of cognitive impairment and efforts to reduce the frequent use of sleeping pills in patients with insomnia might be helpful to reduce the burden of SCD and SCD with functional difficulties in the elderly population.

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