The Frequency of Sleep Medication Use and the Risk of Subjective Cognitive Decline (SCD) or SCD With Functional Difficulties in Elderly Individuals Without Dementia

2019 ◽  
Vol 75 (9) ◽  
pp. 1693-1698 ◽  
Author(s):  
Joo Eun Lee ◽  
Yeong Jun Ju ◽  
Ki Hong Chun ◽  
Soon Young Lee
Keyword(s):  
Cognitive Decline ◽  
Medication Use ◽  
The Elderly ◽  
Subjective Cognitive Decline ◽  
Behavioral Risk ◽  
Elderly Individuals ◽  
Functional Difficulties ◽  
Sleep Medication ◽  
Sleeping Pills ◽  
Frequent Use

Abstract Background The present study investigated whether the frequency of sleep medication use affects subjective cognitive decline (SCD) or SCD with functional difficulties in elderly individuals. Methods The 2018 Korea Community Health Survey data, which consists of national representative and community-based data, was used in this study. A total of 57,050 individuals aged 65 years or older were included in this study. SCD was measured using the Behavioral Risk Factor Surveillance System. A logistic regression analysis was used to analyze the data. Results In total, 16,966 (29.7%) participants had SCD and 3,487 (6.1%) had SCD with functional difficulties. The elderly individuals who took sleep medication more than once a week had higher risks of both SCD and SCD with functional difficulties than those who did not take any sleep medication in a month (SCD: odds ratio [OR] = 1.329, 95% confidence interval [CI] = 1.194–1.480; SCD with functional difficulties: OR = 1.752, 95% CI = 1.491–2.058). Conclusions Frequent sleep medication use was associated with both SCD and SCD with functional difficulties. This study suggests that early detection of cognitive impairment and efforts to reduce the frequent use of sleeping pills in patients with insomnia might be helpful to reduce the burden of SCD and SCD with functional difficulties in the elderly population.

scholarly journals Improving Usefulness of Cognitive Decline Population Measures in Predicting Future Dementia Burden

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 183-183
Author(s):  
Benjamin Olivari ◽  
Christopher Taylor ◽  
Lisa McGuire
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Memory Loss ◽  
Population Level ◽  
Subjective Cognitive Decline ◽  
Behavioral Risk ◽  
Functional Difficulties ◽  
Increased Risk ◽  
Future Burden ◽  
Core Questions

Abstract Alzheimer’s disease and related dementias begin with mild early symptoms of memory loss, progressing to more severe cognitive and functional impairment. Reports of worsening memory and subjective cognitive decline (SCD) are often the earliest possible signs of dementia onset. The trajectory of certain types of dementia may require early detection of worsening memory in the disease progression for successful interventions. However, the predictive value of subjective measures of cognitive decline is limited; the majority of those who report subjective symptoms do not progress to diagnosed cognitive impairment or dementia. These two realities create a significant challenge in confronting the growing dementia crisis. Population-level data can be beneficial in tracking trends in SCD. Data from the Behavioral Risk Factor Surveillance System (BRFSS) core questions related to chronic diseases and from the SCD optional module from survey years 2015-2019 were aggregated across the participating 50 states, D.C., and Puerto Rico for this analysis. Among 181,097 U.S. respondents aged ≥45 years, 11.3% (95% CI=10.9-11.6) reported SCD; among 20,424 with SCD symptoms, 39.4% (37.6-40.6) reported functional difficulties associated with SCD symptoms and 33.9% (32.4-35.5) needed assistance with day-to-day activities resulting from symptoms. Studies suggest persons experiencing SCD symptoms and associated functional difficulties are at increased risk for dementia compared with those with SCD without functional difficulties. Combining responses about SCD with associated functional difficulties, anxiety, and other measures might help to better inform the future burden of more severe cognitive impairment than SCD status alone.

Disparities of Subjective Cognitive Decline Among Native Hawaiians/Other Pacific Islanders, Asian Americans, and White Americans in Hawai‘i: Behavioral Risk Factor Surveillance System 2015 and 2017

2021 ◽  
pp. 101053952110209
Author(s):  
Uyanga Ganbat ◽  
Yan Yan Wu
Keyword(s):  
Cognitive Decline ◽  
Surveillance System ◽  
Pacific Islanders ◽  
Native Hawaiians ◽  
Subjective Cognitive Decline ◽  
Behavioral Risk ◽  
White Americans ◽  
Behavioral Risk Factor ◽  
Behavioral Risk Factor Surveillance ◽  
Risk Factor Surveillance

Existing research on subjective cognitive decline (SCD) among Native Hawaiians/Other Pacific Islanders (NHOPIs) is limited even though NHOPI adults have the highest prevalence of cardiovascular risk factors. In this study, we investigated SCD disparities among NHOPIs, Asian Americans, and White Americans and its contributing factors utilizing the 2015 and 2017 survey year data from the Behavioral Risk Factor Surveillance System (BRFSS) for Hawai‘i State in the United States. The SCD prevalence was 11.9%, 8.97%, and 7.86% among NHOPIs, Whites, and Asians, respectively. Adjusting for sociodemographic and health behavioral variables, the prevalence ratios (PRs) of SCD were 1.37 (95% confidence interval [CI] = 1.05-1.78) for NHOPI versus Asian and 1.15 (95% CI = 0.89-1.50) for NHOPI versus Whites. The associations were weakened after adjusting for health conditions. Depressive disorders, coronary heart disease or myocardial infarction, stroke, and diabetes were associated with cognitive decline in the multivariate-adjusted model. NHOPIs experienced more SCD-related functional difficulties than other races.

The role of Mediterranean diet in the course of subjective cognitive decline in the elderly population of Greece: results from a prospective cohort study

2021 ◽  
pp. 1-29
Author(s):  
George S. Vlachos ◽  
Mary Yannakoulia ◽  
Costas A. Anastasiou ◽  
Mary H. Kosmidis ◽  
Efthimios Dardiotis ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Mediterranean Diet ◽  
The Elderly ◽  
Protective Role ◽  
Subjective Cognitive Decline ◽  
Preventive Strategy ◽  
Food Groups ◽  
Medical Disorders ◽  
The Mediterranean

Abstract Very few data are available regarding the association of adherence to the Mediterranean Diet (MeDi) with Subjective Cognitive Decline (SCD) evolution over time. A cohort of 939 cognitively normal individuals reporting self-experienced, persistent cognitive decline not attributed to neurological, psychiatric or medical disorders from the Hellenic Epidemiological Longitudinal Investigation of Aging and Diet (HELIAD study) was followed-up for a mean period of 3.10 years. We defined our SCD score as the number of reported SCD domains (memory, language, visuoperceptual and executive), ranging from 0 to 4. Dietary intake at baseline was assessed through a food frequency questionnaire; adherence to the MeDi pattern was evaluated through the Mediterranean Diet Score (MDS) that ranged from 0 to 55, with higher values indicating greater adherence to the MeDi. The mean SCD score in our cohort increased by 0.20 cognitive domains during follow-up. After adjustment for multiple potential confounders, we showed that an MDS higher by 10 points was associated with a 7% reduction in the progression of SCD within one year. In terms of food groups, every additional vegetable serving consumption per day was associated with a 2.3% reduction in SCD progression per year. Our results provide support to the notion that MeDi may have a protective role against the whole continuum of cognitive decline, starting at the first subjective complaints. This finding may strengthen the role of the MeDi as a population-wide, cost-effective preventive strategy targeting the modifiable risk factors for cognitive decline.

scholarly journals The Interrelationship Between Subjective Health, Cognitive Decline, and Late Life Disability: A Path Analysis

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 301-301
Author(s):  
Sarah Hubner ◽  
Hyeon Jung Kim ◽  
Brenda Nguyen ◽  
Brooke Hansen ◽  
Julie Blaskewicz Boron
Keyword(s):  
Physical Health ◽  
Cognitive Decline ◽  
Path Analysis ◽  
Subjective Health ◽  
Subjective Cognitive Decline ◽  
Behavioral Risk ◽  
Cognitive Health ◽  
Behavioral Risk Factor Surveillance ◽  
Path Analyses ◽  
The Impact

Abstract Relationships between mental, physical and cognitive health can differentially impact individuals’ ability to function in everyday life. As people age, this can further influence independence and quality of life. To better understand these relationships, the current study implemented path analysis to investigate the impact of subjective mental, physical, and cognitive health on disability. Analyses explored relationships between demographic variables, subjective mental and physical health, cognitive decline, and self-reported disability (difficulty Walking/Climbing stairs [WC], Dressing/Bathing [DB], and Doing Errands [EA]). Data from the Behavioral Risk Factor Surveillance System were examined. The most recent four waves (2015-2018) of available data from states utilizing the Cognitive Decline Module were included (50 states, two territories). Path analyses were conducted and modeled in AMOS. Measures of CFI (0.986), TLI (0.938), and RMSEA (0.046) indicate good model fit. Listwise deletion was utilized (n=212117) . Respondents were aged 45+ and were generally white (82.8%), female (58.7%), and of “good/very good” subjective general health (64.0%). Results revealed being non-white (WCΣβ=0.028, DBΣβ=0.021, EAΣβ=0.025, all p’s<.001), of older age (WCΣβ=0.124, DBΣβ=0.004, EAΣβ=0.001, all p’s<.001), female (WCΣβ=0.016, DBΣβ=0.013, EAΣβ=0.016, all p’s<.001), poorer mental health (WCΣβ=0.080, DBΣβ=0.082, EAΣβ=0.116, all p’s<.001), poorer physical health (WCΣβ=0.410, DBΣβ=0.294, EAΣβ=0.314, all p’s<.001), and presence of subjective cognitive decline (WCΣβ=0.107, DBΣβ=0.107, EAΣβ=0.138, all p’s<.001) all had a positive total effect on disability. Ultimately, these results indicate the interrelationship between subjective health and self-reported ability/disability. These findings may help to improve care considerations for an aging population by serving as indicators for needs for assistance and support.

Overall and Sex-Specific Risk Factors for Subjective Cognitive Decline: Findings From the 2015–2018 Behavioral Risk Factor Surveillance System Survey

2021 ◽  
Author(s):  
Karen Schliep ◽  
Lily Gu ◽  
Kristine Lynch ◽  
Michelle Sorweid ◽  
Michael Varner ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Behavioral Risk ◽  
Behavioral Risk Factor ◽  
Population Attributable Fractions ◽  
Behavioral Risk Factor Surveillance ◽  
Risk Factor Surveillance ◽  
Modifiable Factors ◽  
Attributable Fractions

Abstract Background Prior research indicates that at least 35% of Alzheimer’s disease and related dementia risk may be amenable to prevention. Subjective cognitive decline is often the first indication of preclinical dementia, with the risk of subsequent Alzheimer’s disease in such individuals being greater in women than men. We wished to understand how modifiable factors are associated with subjective cognitive decline, and whether differences exist by sex. Methods Data were collected from men and women (45 years and older) who completed the U.S. Behavioral Risk Factor Surveillance System Cognitive Decline Module (2015–2018), n=216,838. We calculated population attributable fractions for subjective cognitive decline, stratified by sex, of the following factors: limited education, deafness, social isolation, depression, smoking, physical inactivity, obesity, hypertension, and diabetes. Our models were adjusted for age, race, income, employment, marital and Veteran status, and accounted for communality among risk factors. Results The final study sample included more women (53.7%) than men, but both had a similar prevalence of subjective cognitive decline (10.6% of women versus 11.2% of men). Women and men had nearly equivalent overall population attributable fractions to explain subjective cognitive decline (39.7% for women versus 41.3% for men). The top three contributing risk factors were social isolation, depression, and hypertension, which explained three-quarters of the overall population attributable fraction. Conclusions While we did not identify any differences in modifiable factors between men and women contributing to subjective cognitive decline, other factors including reproductive or endocrinological health history or biological factors that interact with sex to modify risk warrant further research.

IC-P-105: IS HIPPOCAMPAL ATROPHY IN HEALTHY ELDERLY INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE RELATED TO AMYLOID DEPOSITION?

2014 ◽  
Vol 10 ◽  
pp. P58-P59
Author(s):  
Audrey Perrotin ◽  
Florence Mézenge ◽  
Brigitte Landeau ◽  
Stéphanie Egret ◽  
Vincent de La Sayette ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Amyloid Deposition ◽  
Subjective Cognitive Decline ◽  
Hippocampal Atrophy ◽  
Elderly Individuals ◽  
Healthy Elderly
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