P4-172: S 44858, a positive allosteric modulator of ampa receptors and GluN2B selective nmda receptors antagonist, prevents the disruption of synaptic plasticity induced by Aβ oligomers

2015 ◽  
Vol 11 (7S_Part_18) ◽  
pp. P845-P845
Author(s):  
Laurence Danober ◽  
Raik Rönicke ◽  
Klaus Reymann ◽  
Tomas Ondrejcak ◽  
Dainan Zhang ◽  
...  
2015 ◽  
Vol 11 (7S_Part_13) ◽  
pp. P612-P613
Author(s):  
Laurence Danober ◽  
Jean-Yves Thomas ◽  
Sylvie Challal ◽  
Nathalie Rogez ◽  
Karine Albinet ◽  
...  

2018 ◽  
Vol 147 (2) ◽  
pp. 222-239 ◽  
Author(s):  
Juliana G. Doria ◽  
Jessica M. de Souza ◽  
Flavia R. Silva ◽  
Isabella G. Olmo ◽  
Toniana G. Carvalho ◽  
...  

2020 ◽  
Vol 173 ◽  
pp. 107971 ◽  
Author(s):  
Feng Yi ◽  
Nirvan Rouzbeh ◽  
Kasper B. Hansen ◽  
Yuelian Xu ◽  
Christopher M. Fanger ◽  
...  

2020 ◽  
Author(s):  
Wenting Su ◽  
Jianan Yu ◽  
Min Li ◽  
Ke Wang ◽  
Chang Liu ◽  
...  

Abstract Background Parkinson's disease is characterized by abnormal synaptic transmission in the corticostriatal circuit that leads to deficits in motor abilities. Electro-acupuncture has shown to improve the motor behaviors in parkinsonian models. However, the potential mechanisms underlying the electro-acupuncture treatment, specifically in the partial-lesioned model, remain unclear. Methods By utilizing multiple approaches, including electrophysiological, immunohistochemistrical, molecular and behavioral methods, we assessed the effect of electro-acupuncture on the motor dysfunction and striatal synaptic plasticity in a partial-lesioned mouse model induced by intrastriatal injection of 6-hydroxydopamine. Results Electro-acupuncture ameliorated the disrupted gross and fine motor skills in 6-hydroxydopamine-lesioned mice. Notably, electro-acupuncture not only restored the injured corticostriatal long-term potentiation, but also reversed the loss of GluN1-containing NMDA receptors and GluA1-containing AMPA receptors in the striatum. Furthermore, the antagonists selective for AMPA receptors and NMDA receptors blocked the effect of electro-acupuncture on the corticostriatal long-term potentiation in 6-hydroxydopamine-treated mice. Conclusions These data suggest that the postsynaptic glutamate receptors in the striatum undergo the maladaptive changes in the early stage of Parkinson's disease. Electro-acupuncture improves the motor skills via a mechanism involving the modulation of corticostriatal synaptic plasticity and specific glutamate receptors in a partial-lesioned rodent model.


2017 ◽  
Vol 121 ◽  
pp. 59-69 ◽  
Author(s):  
Francesca Calabrese ◽  
Elisa Savino ◽  
Elisabeth Mocaer ◽  
Sylvie Bretin ◽  
Giorgio Racagni ◽  
...  

2019 ◽  
Vol 488 (1) ◽  
pp. 304-306
Author(s):  
V. V. Grigoriev ◽  
M. I. Lavrov ◽  
V. L. Zamoyski ◽  
T. L. Garibova ◽  
V. A. Palyulin ◽  
...  

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184429 ◽  
Author(s):  
Sylvie Bretin ◽  
Caroline Louis ◽  
Laure Seguin ◽  
Stéphanie Wagner ◽  
Jean-Yves Thomas ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document