New Positive Allosteric Modulator of AMPA Receptors: in vitro and in vivo Studies

2019 ◽  
Vol 488 (1) ◽  
pp. 304-306
Author(s):  
V. V. Grigoriev ◽  
M. I. Lavrov ◽  
V. L. Zamoyski ◽  
T. L. Garibova ◽  
V. A. Palyulin ◽  
...  
Keyword(s):  
Ampa Receptors ◽  
In Vivo Studies ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator

scholarly journals New positive allosteric modulator of AMPA-receptors: in vitro and in vivo studies

2019 ◽  
Vol 488 (2) ◽  
pp. 217-220
Author(s):  
V. V. Grigoriev ◽  
M. I. Lavrov ◽  
V. L. Zamoyski ◽  
T. L. Garibova ◽  
V. A. Palyulin ◽  
...  
Keyword(s):  
Ampa Receptors ◽  
Neurological Diseases ◽  
In Vivo Studies ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Promising Candidate ◽  
Experimental Animals ◽  
Preclinical And Clinical Studies

A new derivative of 3,7-diazabicyclo[3.3.1]nonane was studied in electrophysiological experiments, which showed high activity as a positive allosteric modulator of AMPA receptors of the CNS. In doses of 0.01 mg/kg this compound significantly improved the memory of experimental animals disturbed by maximal electric shock. The results indicate that this compound is a promising candidate for preclinical and clinical studies as a treatment for a number of psycho-neurological diseases.

In vitro and in vivo characterization of PheTQS, a novel α7 nAChR positive allosteric modulator

2009 ◽  
Vol 78 (7) ◽  
pp. 913 ◽  
Author(s):  
James N.C. Kew ◽  
Selina Mok ◽  
Annette Weil ◽  
Caterina Virginio ◽  
Laura Castelletti ◽  
...  
Keyword(s):  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Α7 Nachr ◽  
In Vivo Characterization

In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB positive allosteric modulator

2016 ◽  
Vol 791 ◽  
pp. 115-123 ◽  
Author(s):  
Alessandra Porcu ◽  
Carla Lobina ◽  
Daniela Giunta ◽  
Maurizio Solinas ◽  
Claudia Mugnaini ◽  
...  
Keyword(s):  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Pharmacological Characterization

P2-311: In vitro characterization of s44858: A positive allosteric modulator of ampa receptors and GluN2B selective non-competitive nmda receptors antagonist

2015 ◽  
Vol 11 (7S_Part_13) ◽  
pp. P612-P613
Author(s):  
Laurence Danober ◽  
Jean-Yves Thomas ◽  
Sylvie Challal ◽  
Nathalie Rogez ◽  
Karine Albinet ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Ampa Receptors ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
In Vitro Characterization

In vitro and in vivo characterization of the novel GABAB receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE)

2011 ◽  
Vol 61 (5-6) ◽  
pp. 957-966 ◽  
Author(s):  
Elisabetta Perdona’ ◽  
Vivian J.A. Costantini ◽  
Michela Tessari ◽  
Prisca Martinelli ◽  
Corrado Carignani ◽  
...  
Keyword(s):  
Gabab Receptor ◽  
Allosteric Modulator ◽  
The Novel ◽  
Positive Allosteric Modulator ◽  
In Vivo Characterization
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