P3-145: Diagnostic Methods for Normal Pressure Hydrocephalus in a National Reference Neurological Center in Mexico City: A Case Series

2016 ◽  
Vol 12 ◽  
pp. P874-P874
Author(s):  
Leo Bayliss ◽  
Ana Luisa Sosa-Ortiz
Keyword(s):  
Mexico City ◽  
Normal Pressure Hydrocephalus ◽  
Case Series ◽  
Normal Pressure ◽  
Diagnostic Methods ◽  
National Reference

scholarly journals Ventriculoperitoneal Shunt Outcomes of Normal Pressure Hydrocephalus: A Case Series of 116 Patients

Cureus ◽  
2019 ◽  
Author(s):  
Eva M Wu ◽  
Tarek Y Ahmadieh ◽  
Benjamin Kafka ◽  
James Caruso ◽  
Salah G Aoun ◽  
...  
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Ventriculoperitoneal Shunt ◽  
Case Series ◽  
Normal Pressure

Normal pressure hydrocephalus or progressive supranuclear palsy? A clinicopathological case series

2012 ◽  
Vol 260 (4) ◽  
pp. 1009-1013 ◽  
Author(s):  
Nadia K. Magdalinou ◽  
Helen Ling ◽  
James D. Shand Smith ◽  
Jonathan M. Schott ◽  
Laurence D. Watkins ◽  
...  
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Normal Pressure Hydrocephalus ◽  
Case Series ◽  
Normal Pressure

scholarly journals Comparative Stereological Analysis of Intracranial Volume fractions among Patients with Brain Atrophy and Normal Pressure Hydrocephalus from a Nigerian Population

2021 ◽  
Vol 3 (2) ◽  
pp. 192-196
Author(s):  
Mohammed Abba ◽  
Anthony Chukwuka Ugwu ◽  
Azuoma L. Asomugha ◽  
Hassan Ismail
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Brain Atrophy ◽  
Matched Control ◽  
Volume Fraction ◽  
Normal Pressure ◽  
Volume Estimation ◽  
Diagnostic Methods ◽  
Intracranial Volume ◽  
Cross Sectional ◽  
Volume Fractions

Background: Differentiation between symptoms of normal pressure hydrocephalus (NPH) and other neurodegenerative disorders such as Brain Atrophy (BA) are usually confusing. Available diagnostic methods are invasive while the few non-invasive methods did not take care of potential factors known to influence intracranial volumes. We, therefore, aim to determine and compare the intracranial volume fractions among patients with NPH and BA. Methods: This was a prospective, cross-sectional age-matched control study among consenting patients that were diagnosed with NPH, BA and healthy control in Aminu Kano Teaching Hospital from March 2018 to November 2020. Each patient was routinely examined with CT-Scan; However, control participants were from other reasons. Participants with a medical history known to influence the intracranial volume were excluded. Volume estimation was based on a stereological Cavalieri method and three volume fractions were determined mathematically for each of the group. Test-point computing was facilitated through a locally developed software (voXas_2018). Ethical approval was sort prior to the study. Results: Patients with NPH have higher total CSF: brain ratio, intraventricular volume: brain ratio and extra-ventricular: brain ratio. Similar pattern was exhibited according to age grouping, except in the older age category where BA volume fractions were higher. Conclusion: Age, gender and statue are known to influence intracranial volumes. We controlled their potential effects through age-matched control of participants between groups and the use of intracranial volume ratios for objective diagnosis of NPH and BA. However, Tcsf:Br and InV:Br volume fraction ratios were found to be reliable indices for distinguishing patients with NPH and BA.

scholarly journals A Distinct Scenario of a Patient with Parkinson’s Disease and Comorbid Normal Pressure Hydrocephalus

2020 ◽  
Vol 9 (02) ◽  
pp. 127-130
Author(s):  
Halil Onder
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Treatment Process ◽  
Case Series ◽  
Normal Pressure ◽  
Extrapyramidal Side Effects ◽  
Antipsychotic Medications ◽  
Neurodegenerative Pathology ◽  
Long Term Follow Up

AbstractIn literature, patients with coexistence of normal pressure hydrocephalus (NPH) and Parkinsons’s disease (PD) have been rarely reported. Herein, I illustrate the evaluation processes of a remarkable patient with PD and comorbid NPH from my experience, which I think may provide crucial perspectives regarding the management problems of these patients. Besides, the patient had also developed bipolar disorder in the follow-up course and extrapyramidal side effects related to antipsychotic medications, which further complicated the treatment process. I think that results of future reports of larger case series including the long-term follow-up of this group of patients with coexisting NPH and PD would provide substantial perspectives regarding the contributory effects of these two pathophysiologies, as well as management, of NPH in these specific patients with neurodegenerative pathology.

TM3-9 Neurosarcoidosis presenting with normal pressure hydrocephalus: case series

2019 ◽  
Vol 90 (3) ◽  
pp. e17.2-e17
Author(s):  
AK Golahmadi ◽  
CL Craven ◽  
LT Thorne ◽  
AK Toma ◽  
LD Watkins
Keyword(s):  
Mr Imaging ◽  
Normal Pressure Hydrocephalus ◽  
Medical Management ◽  
Early Recognition ◽  
Combined Treatment ◽  
Case Series ◽  
Normal Pressure ◽  
Symptom Improvement ◽  
Shunt Insertion ◽  
Csf Diversion

ObjectivesNeurosarcoidosis is a rare condition with a high mortality. Early recognition of symptoms is important to enable prompt interventions. We report a case series of NS with ventriculomegaly that presented with symptoms resembling normal pressure hydrocephalus (NPH).DesignCase series.SubjectsPatients with ventriculomegaly on MR imaging and diagnosis of confirmed or probable NS.MethodsAnalysis of medical records for presenting clinical features, neuroradiology, intervention and clinical outcomes in patients with ventriculomegaly and confirmed or probable NS.ResultsFour patients (2M:2F) aged 49.0±3.01 years (mean ±SD) were identified. Three had definite NS and one probable. Three presented with gait disturbance and one with memory impairment. MR Imaging (with gadolinium) demonstrated ventriculomegaly with leptomeningeal enhancement. One patient underwent 24 hour ICPM, with a median ICP of 3.47 mmHg and pulse amplitude of 4.35 mmHg. CSF showed mild increase in chronic inflammatory cells in the absence of infection. Patients underwent medical management plus ventriculoperionteal shunt insertion (with adjustable valves set to 5 cm H2O and anti-siphon devices). There was a propensity for transient development of slit-like ventricles but without other features of over-drainage. All patients showed symptom improvement following CSF diversion at mean follow-up of 27 months.ConclusionsNS can present similarly to NPH. Early combined treatment of CSF diversion and medical management is effective for symptom management.

scholarly journals Normal Pressure Hydrocephalus Secondary to Intracranial Mass: A Case Series

2017 ◽  
Vol 4 (2) ◽  
pp. 1-4
Author(s):  
Noman Lateef ◽  
◽  
Abdul Basit Ansari ◽  
Abubakar Tauseef ◽  
Aneela Darbar
Keyword(s):  
Normal Pressure Hydrocephalus ◽  
Case Series ◽  
Normal Pressure ◽  
Intracranial Mass

scholarly journals Tularemia: A Case Series of Patients Diagnosed at the National Reference Center for Rickettsioses From 2008 to 2017

2020 ◽  
Vol 7 (11) ◽  
Author(s):  
Anne Darmon-Curti ◽  
François Darmon ◽  
Sophie Edouard ◽  
Aurélie Hennebique ◽  
Thomas Guimard ◽  
...  
Keyword(s):  
Leisure Activities ◽  
Case Series ◽  
Epidemiological Data ◽  
Diagnostic Methods ◽  
Reference Center ◽  
National Reference ◽  
Single Positive ◽  
Splenic Hematoma ◽  
National Reference Center ◽  
Pcr Targeting

Abstract Background We describe the epidemiological, clinical, and prognostic aspects of 177 tularemia cases diagnosed at the National Reference Center for rickettsioses, coxiellosis, and bartonelloses between 2008 and 2017. Methods All patients with a microbiological diagnosis of tularemia made in the laboratory were included. Clinical and epidemiological data were collected retrospectively from clinicians in charge of patients using a standardized questionnaire. Diagnostic methods used were indirect immunofluorescence serology, real-time polymerase chain reaction (PCR), and universal PCR targeting the 16S ribosomal ribonucleic acid gene. Results The series included 54 females and 123 males (sex ratio, 2.28; mean age, 47.38 years). Eighty-nine (50.2%) were confirmed as having tularemia on the basis of a positive Francisella tularensis PCR or seroconversion, and 88 (49.8%) were considered as probable due to a single positive serum. The regions of France that were most affected included Pays de la Loire (22% of cases), Nouvelle Aquitaine (18.6% of cases), and Grand Est (12.4% of cases). Patients became infected mainly through contact with rodents or game (38 cases, 21.4%), through tick-bites (23 cases, 12.9%), or during outdoor leisure activities (37 cases, 20.9%). Glandular and ulceroglandular forms were the most frequent (109 cases, 61.5%). Two aortitis, an infectious endocarditis, a myocarditis, an osteoarticular infection, and a splenic hematoma were also diagnosed. Tularemia was discovered incidentally in 54.8% of cases. Seventy-eight patients were hospitalized, and no deaths were reported. Conclusions Our data suggest that in an endemic area and/or in certain epidemiological contexts, tularemia should be sought to allow an optimized antibiotic therapy and a faster recovery.

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