Fundamental Aspects of Vedic Sciences by Yajna Vijnan and Mantra Therapy

The Present manuscript discusses on various scientific aspects of Indian Vedic Agnihotra Vijnan and Mantra therapy. It has been scientifically proven in many recent experiemnts and literature that Homa therapy is much effective in inviting rainy clouds, efficient in disesaes control through inhaling therapy, generates negative ions responsible for happiness, organic homa krishi (farming) is best for humans, boon for mental and physical fitness. The authors’ team have tried best to present a series of small experiemnts in support of few of above results and confident enough that gradually this therapy is poular and being accepted globally by one and all. Indian culture and science is scientific and full of components to uplift the human conciousness and ease in life. The present study supports this fact by visualizations and sensor based experiemnts. In 21st century, it is crucial to accept with open minded the good features of this alternate therapy in view of second and third and multiple waves of pandemic caused by sars-cov’19 and other global threats.

DREAMseq (Doublet, Randomized Evaluation in Advanced Melanoma Sequencing): A phase III trial—ECOG-ACRIN EA6134.

356154 Background: Combinations of immune checkpoint inhibitors (CPI) blocking PD-1 and CTLA-4 or BRAF/MEK inhibitors have both shown significant antitumor efficacy and overall survival (OS) benefit in patients (pts) with BRAFV600-mutant metastatic melanoma (MM), leading to broad regulatory approval. Little prospective data exists to guide the choice of one over the other as initial therapy or the preferred treatment sequence in this population. The DREAMseq Trial was designed to compare the efficacy and toxicity of the sequence of nivolumab/ipilimumab (N/I) followed by dabrafenib/trametinib (D/T) to the converse sequence. Methods: Eligible pts with treatment-naive BRAFV600-mutant MM were stratified by ECOG Performance Status (PS) 0 or 1 and LDH level and randomized 1:1 to receive Step 1 with either N/I (Arm A) or D/T (Arm B) and at disease progression (PD) were enrolled in Step 2 receiving the alternate therapy, D/T (Arm C) or N/I (Arm D), respectively. Pts received N (1mg/kg)/I (3 mg/kg) q3 wks x 4 doses followed by N 240 IV q2 wks for up to 72 wks (Arms A and D) or D 150 mg po BID and T 2 mg po qD until PD (Arms B and C). In 2019, investigators were given the option to use alternate induction dosing of N (3mg/kg)/I (1 mg/kg) q3 wks x 4 doses for Arms A and D. Cycles were every 6 wks and imaging was obtained at baseline and q12 wks on each arm. Primary endpoint was 2-year OS. At the 4th Interim Analysis with 59% of pts being 2 yrs from enrollment, the DSMC and NCI CTEP recommended halting accrual and releasing the data. Results: Beginning 7/2015, 265 out of a proposed 300 pts were enrolled (133 Arm A and 132 Arm B). Median age was 61 (25-85) and 63% were male. Demographics for Arm A and B were balanced with 67% PS 0 and 60% with normal LDH. As of 7/16/21, at a median follow-up of 27.7 mos, 27 pts had switched to Arm C and 46 to Arm D. Overall Grade 3+ toxicity was 60% in Arm A and 52% in Arm B. Grade 5 treatment-related AEs included 2 on Arm A and 1 on Arm C. ORR to date is: Arm A 46% (52/113), Arm B 43% (49/114), Arm C 48% (11/23) and Arm D 30% (8/27). 37/42 assessed pts in Arm A and 19/37 in Arm B remain in response. Median DOR: Arm A- Not reached; Arm B-12.7 mos (95% CI: 8.2, -) (p <0.001). There were 100 deaths (Arm A to C- 38/Arm B to D- 62). 2-yr OS rate for those starting with Arm A was 72% (95% CI: 62-81%) and for Arm B 52% (95% CI: 42-62%) (log-rank p= 0.0095). PFS showed a trend in favor of Arm A (log-rank p=0.054). Both the PFS and OS curves show a biphasic pattern with Arm B being above Arm A until 6 and 10 mos, respectively. For the 115 pts with documented progression on Step 1 (Arm A-44/Arm B-71), 60 (52%) had registered for Step 2. The principal reason for not enrolling on Step 2 was death from PD within 6 mos (Arm A:15/23; Arm B: 25/32). Conclusions: For pts with advanced BRAFV600-mutant MM, the treatment sequence beginning with the CPI combination of N/I resulted in superior OS, which became evident at 10 mos, with longer Step 1 DOR and more ongoing responses than the treatment sequence beginning with D/T. Clinical trial information: NCT02224781.

Efficacy of Mrudu Samvahana (Forehead Massage) over Takra Dhara (Buttermilk Dripping Therapy) in Anxiety and Stress Induced Essential Hypertension – A Randomized Clinical Trial.

Blood pressure level measuring above 140/90 mm of Hg is termed as hypertension. Hypertension is associated with various risk factors and also is mainly responsible for mortality in industrialized countries. The treatment for hypertension in modern science is palliative in nature. Many of these, along with its effectiveness in controlling the blood pressure, cause adverse side effects; hence the need for the hour is an alternate therapy with no potential side effects. Ayurveda has potential medicines to alleviate hypertension without causing any side effects. The study was to evaluate clinical efficacy of two Ayurveda procedures Mrudu Samvahana and Takradhaara in essential hypertension. The study included a total of 40 patients, attending the Outpatient department of KLE Ayurveda hospital, randomized into Group A and Group B of 20 each. The patients in group A received Mrudu samvaahana with Murchita tila taila which was performed 20 minutes per day for 7 days. The patients in group B received Takra dhara with Amalaki siddha takra which was performed 40 minutes per day for 7 days. Statistical analysis revealed that both groups Mrudu Samvahana and Takradhara showed significant (P< 0.0001) results determined by unpaired T test in objective parameters. Between the group assessment. revealed that Takra dhara has shown better results compared to mrudu samvahana in reduction of systolic and diastolic blood pressure. (P<0.0048).

Efficacy of Siddha medicine in the treatment of COVID- 19 patients - A pilot study

The pandemic triggered by coronavirus disease (COVID-19) invariably questions the health security of people around the globe. It’s also strongly advocates the need for unique health care practice that substantially prevents the infection and practice of controlling the disease transmission. Alternate therapy with viable medications that can adequately strengthen the immune system to enhance the speedy recovery of the patients becomes the need of the hour. Siddha system of medicine is one such versatile practice that emerged before centuries that incorporates the practice of availing potential remedies from herbal and another natural origin. Still, now there is no proper documentary evidence on evaluating the efficacy of Siddha treatment in the clinical management of COVID-19, hence the main objective of the present pilot study is to investigate the potential of Siddha formulations such as Aadathodai kudineer, Thaalisaathi chooranam, Thulasi chooranam, Pavala parpam, Bramaanandha Bairava Maathirai and Thoothuvalai nei in treatment and accelerating the recovery of COVID19 patients. A Study was executed in 25 patients with laboratory- confirmed diagnosis of COVID-19. The Outcome of the present clinical study signifies that treatment with Siddha medicines significantly accelerated recovery of patients by stabilising the immune mechanism which was evidenced by pronouncing declination in CRP (C- reactive protein), neutrophil, lymphocytes, Lactate dehydrogenase (LDH), Creatinine, Serum Albumin and Serum Urea level almost back to the normal. In conclusion therapy with Siddha medicines opened a new gateway in the clinical practice on managing COVID-19 due presence of vital phytotherapeutics that showcase multiple pharmacological activities against risky pathogens like SARS-CoV-2.

Review on Health Benefits of Spearmint (Mentha spicata L.) and Its Inter-cropping Advantage with Maize (Zea mays L.)

Traditional medicine provides an important health care service and can be used as an alternate therapy. Plants are rich in phytochemical compounds that offer a source of dietary ingredients used to treat various ailments and problems. Spearmint (Mentha spicata L.) belongs to the family Lamiaceae and is a rich source of polyphenols. These polyphenols have shown numerous biological activities and health benefits. Also, conserve biodiversity and manage soil-borne pests as well as enhance soil and plant health. Therefore, the review of the present study shows the bioactivity, health effects, and inter-cropping advantages of spearmint.

Deciphering the Antibacterial Role of Peptide From Bacillus subtilis subsp. spizizenii Ba49 Against Staphylococcus aureus

An increase in antibiotic resistance has led to escalating the need for the development of alternate therapy. Antimicrobial peptides (AMPs) are at the forefront of replacing conventional antibiotics, showing slower development of drug resistance, antibiofilm activity, and the ability to modulate the host immune response. The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens that jeopardize most conventional antibiotics are known to be involved in severe respiratory tract, bloodstream, urinary tract, soft tissue, and skin infections. Among them, S. aureus is an insidious microbe and developed resistance against conventional antibiotics. In the present study, an AMP (named as peptide-Ba49) isolated from Bacillus subtilis subsp. spizizenii strain from Allium cepa (the common onion) exhibited strong antibacterial efficacy against S. aureus ATCC 25923. The mode of action of this peptide-Ba49 on S. aureus was deciphered through various sensitive probes, i.e., DiSC3 (5) and H2DCFDA, suggesting the peptide-Ba49 to be acting upon through change in membrane potential and by triggering the production of reactive oxygen species (ROS). This induced disruption of the cell membrane was further supported by morphological studies using scanning electron microscopy (SEM). Investigations on a possible post-antibiotic effect (PAE) of peptide-Ba49 showed prolonged PAE against S. aureus. Furthermore, the peptide-Ba49 prevented the formation of S. aureus biofilm at low concentration and showed its potential to degrade the mature biofilm of S. aureus. The peptide-Ba49 also exhibited intracellular killing potential against S. aureus ATCC 25923 in the macrophage cells, and moreover, peptide-Ba49 was found to bolster the fibroblast cell migration in the scratch assay at low concentration, exhibiting a wound healing efficacy of this peptide. These studies demonstrated that peptide-Ba49 isolated from the strain B. subtilis subsp. spizizenii could be a therapeutic candidate to combat the pathogenic S. aureus infections.

Treatment Case Studies and Emissions Analysis of Wood in Yagya

The mantra becomes more powerful when that sound is chanted in front of purified fire and light; sound and heat energy mixtures are converted into high level of energy and spread around the atmosphere. Through this paper, the well experienced author team of various domains is continuously working in experimenting in joint collaboration with different GoI departments. They have observed the slow but continuous progress in different ails on many subjects through scientific study and approach. The main case studies where the patients got significant benefits through this alternate therapy have been systematically presented here. The power of yajna and mantra has attracted the intellectuals of this era. In the future, we may expect some automated intelligent healthcare expert system using this way of life. Yagya science and its treatment power of different diseases is surprising; the need is that current science should accept it logically with an open mind and heart and let the humanity take the complete benefit of it.

Vascular Anomalies of the Oro-Maxillofacial Region

Vascular anomalies is a diverse group of disorders involving the vasculature (arteries,veins and lymphatics). These lesions in the head and neck can present since birth or later in life causing functional, cosmetic and bleeding problems. They can sometimes co-exist with a wide array of other pathologies and components of various syndromes. The different types, classifications, clinical features, imaging characteristics, treatment options and complications will be discussed in detail, with accordance to guidelines and principles in current literature. The author has designed a widely accepted anatomical classification for surgical management of these complex lesions, which is discussed in depth. Tailoring therapy depending on the anomaly is the key to successful treatment. Hemangiomas tend to proliferate and then involute , hence treated with systemic medication or alternate therapy for residual lesions. Vascular Malformations essentially would require aggressive management with surgery or embolisation and surgery. The concept of ‘corset suturing’ is explained and described, which is thought to be the ideal management for large venous malformations.