IN-SILICO MODEL OF THE NATURAL HISTORY OF ALZHEIMER’S DISEASE BASED ON SERIAL ACQUISITIONS OF MR, AV45 AND FDG PET SCANS

2017 ◽  
Vol 13 (7) ◽  
pp. P1550-P1551
Author(s):  
Marco Lorenzi ◽  
Maurizio Filippone ◽  
Alberto Redolfi ◽  
Silvia Bianchetti ◽  
Daniel C. Alexander ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural History ◽  
Fdg Pet ◽  
In Silico ◽  
In Silico Model ◽  
History Of ◽  
Pet Scans

scholarly journals Integrating Biomarker Outcomes into Clinical Trials for Alzheimer’s Disease in Down Syndrome

2020 ◽  
pp. 1-4 ◽  
Author(s):  
M.S. Rafii ◽  
S. Zaman ◽  
B.L. Handen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trial ◽  
Clinical Trials ◽  
Down Syndrome ◽  
Natural History ◽  
New Information ◽  
History Of ◽  
Clinically Meaningful Outcomes

The NIH-funded Alzheimer’s Biomarker Consortium Down Syndrome (ABC-DS) and the European Horizon 21 Consortium are collecting critical new information on the natural history of Alzheimer’s Disease (AD) biomarkers in adults with Down syndrome (DS), a population genetically predisposed to developing AD. These studies are also providing key insights into which biomarkers best represent clinically meaningful outcomes that are most feasible in clinical trials. This paper considers how these data can be integrated in clinical trials for individuals with DS. The Alzheimer’s Clinical Trial Consortium - Down syndrome (ACTC-DS) is a platform that brings expert researchers from both networks together to conduct clinical trials for AD in DS across international sites while building on their expertise and experience.

scholarly journals O2-09-01: THE NATURAL HISTORY OF ALZHEIMER'S DISEASE IN DOWN SYNDROME

2019 ◽  
Vol 15 ◽  
pp. P558-P560
Author(s):  
Juan Fortea ◽  
Eduard Vilaplana ◽  
Maria Carmona-Iragui ◽  
Bessy Benejam ◽  
Susana Fernandez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Natural History ◽  
History Of

scholarly journals Overlap between frontotemporal dementia and Alzheimer’s disease: case report

2017 ◽  
Vol 3 (2) ◽  
Author(s):  
Maria Elena Di Battista ◽  
Maurizio Gallucci
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fdg Pet ◽  
Memory Loss ◽  
Behavioral Changes ◽  
Neuropsychological Profile ◽  
Disease Case ◽  
Severe Impairment ◽  
History Of ◽  
Executive Dysfunctions

The <em>frontal variant of Alzheimer’s disease</em> (fv-AD) has been described in patients with prominent behavioral or executive dysfunctions. Subsequently, the spectrum of frontal variant Alzheimer’s disease has been enlarged to comprise patients with early personality and behavioral changes including disinhibition, apathy or compulsiveness. We describe the case of a patient with a history of memory loss and behavioral changes. The neuropsychological profile overlapped with the presence of behavioral disorders such as marked apathy, disinhibition, hostile behavior, agitation, irritability and hyperorality. The results of the neuropsychological examination leaned towards a diagnosis of frontotemporal circuit functional impairment, however, the 18-FDG PET study demonstrated a moderate-to-severe impairment in the bilateral parietal regions. On the basis of the neuropsychological profile and 18-FDG PET imaging, a diagnosis of a probable fv-AD was made, the patient started oral rivastigmine 3 mg/daily and subsequent assessments showed only modest worsening in the cognitive profile and a moderate improvement in behavioral symptoms.

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