P3-100: ASSOCIATION OF RS3846662 AS A GENETIC MODIFIER FOR ALZHEIMER'S DISEASE: THE CACHE COUNTY STUDY

2006 ◽  
Vol 14 (7S_Part_20) ◽  
pp. P1105-P1105
Author(s):  
Sage M. Wright ◽  
Samantha L. Jensen ◽  
Kristen L. Cockriel ◽  
Brian Davis ◽  
Josue D. Gonzalez Murcia ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Modifier ◽  
Cache County

Genetic Modifiers of Tauopathy in Drosophila

Genetics ◽  
2003 ◽  
Vol 165 (3) ◽  
pp. 1233-1242
Author(s):  
Joshua M Shulman ◽  
Mel B Feany
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Mechanisms ◽  
Genetic Modifier ◽  
Genetic Modifiers ◽  
Protein Tau ◽  
Major Class ◽  
Drosophila Model ◽  
Tau Kinases

Abstract In Alzheimer's disease and related disorders, the microtubule-associated protein Tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles. Mutations in the tau gene cause familial frontotemporal dementia. To investigate the molecular mechanisms responsible for Tau-induced neurodegeneration, we conducted a genetic modifier screen in a Drosophila model of tauopathy. Kinases and phosphatases comprised the major class of modifiers recovered, and several candidate Tau kinases were similarly shown to enhance Tau toxicity in vivo. Despite some clinical and pathological similarities among neurodegenerative disorders, a direct comparison of modifiers between different Drosophila disease models revealed that the genetic pathways controlling Tau and polyglutamine toxicity are largely distinct. Our results demonstrate that kinases and phosphatases control Tau-induced neurodegeneration and have important implications for the development of therapies in Alzheimer's disease and related disorders.

O3-11-05: Mitochondrial variation associated with decreased Alzheimer's disease incidence in the Cache County Study on Memory Health and Aging

2012 ◽  
Vol 8 (4S_Part_12) ◽  
pp. P452-P452
Author(s):  
Perry Ridge ◽  
Taylor Maxwell ◽  
Chris Corcoran ◽  
JoAnn Tschanz ◽  
Richard Cawthon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Incidence ◽  
Cache County

Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study

2001 ◽  
Vol 16 (11) ◽  
pp. 1043-1053 ◽  
Author(s):  
Constantine G. Lyketsos ◽  
Jeannie-Marie E. Sheppard ◽  
Martin Steinberg ◽  
Jo Ann T. Tschanz ◽  
Maria C. Norton ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Clusters ◽  
Cache County

scholarly journals The Cache County Study on Memory in Aging: Factors affecting risk of Alzheimer's disease and its progression after onset

2013 ◽  
Vol 25 (6) ◽  
pp. 673-685 ◽  
Author(s):  
Joann T. Tschanz ◽  
Maria C. Norton ◽  
Peter P. Zandi ◽  
Constantine G. Lyketsos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Factors Affecting ◽  
Cache County ◽  
Aging Factors

scholarly journals Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study

2014 ◽  
Vol 35 (11) ◽  
pp. 2429-2435 ◽  
Author(s):  
Yi-Fang Chuang ◽  
John C.S. Breitner ◽  
Yen-Ling Chiu ◽  
Ara Khachaturian ◽  
Kathleen Hayden ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cache County ◽  
Reduced Risk

scholarly journals Sex Differences in Risk for Alzheimer’s Disease Related to Neurotrophin Gene Polymorphisms: The Cache County Memory Study

2017 ◽  
Vol 72 (12) ◽  
pp. 1607-1613 ◽  
Author(s):  
Joshua Matyi ◽  
JoAnn T Tschanz ◽  
Gail B Rattinger ◽  
Chelsea Sanders ◽  
Elizabeth K Vernon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Differences ◽  
Gene Polymorphisms ◽  
Cache County

scholarly journals P3-052: Neuropsychiatric syndromes in Alzheimer's disease: Relationship to cognitive and functional progression. The Cache County dementia progression study

2008 ◽  
Vol 4 ◽  
pp. T532-T532
Author(s):  
Katherine Treiber ◽  
Huibo Shao ◽  
Peter Zandi ◽  
Martin Steinberg ◽  
Chris Corcoran ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cache County

scholarly journals P2-145: Risk factors for severe dementia from a population-based sample of incident Alzheimer's Disease: The Cache County Dementia Progression Study.

2011 ◽  
Vol 7 ◽  
pp. S356-S356 ◽  
Author(s):  
Peter Rabins ◽  
Sarah Schwartz ◽  
JoAnn Tschanz ◽  
Chris Corcoran ◽  
Betty Black ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Population Based ◽  
Severe Dementia ◽  
Cache County
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