Valproic Acid Treatment Attenuates Degenerative Brain Lesions, Neuroinflammation, and Apoptosis in Long-Term Survival Model of Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in Swine

2018 ◽  
Vol 227 (4) ◽  
pp. e186
Author(s):  
Panpan Chang ◽  
Aaron M. Williams ◽  
Isabel S. Dennahy ◽  
Umar F. Bhatti ◽  
Baoling Liu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Acid Treatment ◽  
Brain Lesions ◽  
Survival Model ◽  
Term Survival ◽  
Long Term Survival

TP2-3 Long-term survival and five year hospital resource usage following traumatic brain injury in scotland from 1997–2015: a population-based retrospective cohort study

2019 ◽  
Vol 90 (3) ◽  
pp. e14.2-e14
Author(s):  
JJM Loan ◽  
NW Scott ◽  
JO Jansen
Keyword(s):  
Traumatic Brain Injury ◽  
Cohort Study ◽  
Brain Injury ◽  
Population Based ◽  
Resource Usage ◽  
Hospital Resource ◽  
Post Injury ◽  
Term Survival ◽  
Long Term Survival

AimTo determine if survival and hospital resource usage differ following traumatic brain injury (TBI) compared with head injury without neurological injury(HI).MethodsThis retrospective population-based cohort study included all 25 319 patients admitted to a Scottish NHS hospital from 1997–2015 with TBI. Participants were identified using previously validated ICD-10 based definitions. For comparison, all 194 049 HI cases were identified. Our main outcome measures were hazards of all-cause mortality after TBI, compared with HI, over 18 years follow-up period; and odds of mortality at one month post-injury. Number of days spent as inpatients and number of outpatient attendances per surviving month post-injury were used as measures of resource utilisation.ResultsThe adjusted odds ratio for mortality in the first month post-injury for TBI was 7.12 (95% confidence interval [CI] 6.73–7.52; p<0.001). For the remaining 18 year study period, the hazards of morality after TBI were 0.93 (CI 0.90–0.96; p<0.001). TBI was associated with 2.15 (CI 2.10–2.20; p<0.001) more days spent as inpatient and 1.09 times more outpatient attendances (CI 1.07–1.11; p<0.001) than HI.ConclusionsAlthough initial mortality following TBI is high, survivors of the first month can achieve comparable long-term survival to HI. However this is associated with increased utilisation of hospital services in the TBI group.

Long-Term Survival After Traumatic Brain Injury Part I: External Validity of Prognostic Models

2015 ◽  
Vol 96 (6) ◽  
pp. 994-999.e2 ◽  
Author(s):  
Jordan C. Brooks ◽  
Robert M. Shavelle ◽  
David J. Strauss ◽  
Flora M. Hammond ◽  
Cynthia L. Harrison-Felix
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
External Validity ◽  
Prognostic Models ◽  
Term Survival ◽  
Long Term Survival

Long-Term Survival After Traumatic Brain Injury Part II: Life Expectancy

2015 ◽  
Vol 96 (6) ◽  
pp. 1000-1005 ◽  
Author(s):  
Jordan C. Brooks ◽  
Robert M. Shavelle ◽  
David J. Strauss ◽  
Flora M. Hammond ◽  
Cynthia L. Harrison-Felix
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Life Expectancy ◽  
Term Survival ◽  
Long Term Survival

Valproic Acid Treatment Rapidly Modulates the Proteomic Profile in a Porcine Model of Hemorrhagic Shock and Traumatic Brain Injury

2017 ◽  
Vol 225 (4) ◽  
pp. S67
Author(s):  
Michael B. Weykamp ◽  
Vahagn C. Nikolian ◽  
Isabel S. Dennahy ◽  
Patrick E. Georgoff ◽  
Gerry A. Higgins ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Acid Treatment ◽  
Porcine Model ◽  
Proteomic Profile
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