scholarly journals Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity

2021 ◽  
pp. 101148
Author(s):  
Hyunsup Kim ◽  
Hyemin Choi ◽  
Jun-Sub Im ◽  
Soon-Young Park ◽  
Gwangsu Shin ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Helicase Activity ◽  
Dna Double Strand Break ◽  
Stable Maintenance ◽  
In Cells

A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans

DNA Repair ◽  
2007 ◽  
Vol 6 (6) ◽  
pp. 818-829 ◽  
Author(s):  
Takamitsu A. Kato ◽  
Paul F. Wilson ◽  
Hatsumi Nagasawa ◽  
Markus M. Fitzek ◽  
Michael M. Weil ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Dna Double Strand Break ◽  
Normal Humans ◽  
In Cells

Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients

DNA Repair ◽  
2006 ◽  
Vol 5 (2) ◽  
pp. 251-257 ◽  
Author(s):  
Niall G. Howlett ◽  
Zorica Scuric ◽  
Alan D. D’Andrea ◽  
Robert H. Schiestl
Keyword(s):  
Nijmegen Breakage Syndrome ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Break Repair ◽  
In Cells

scholarly journals BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites

2017 ◽  
Vol 216 (11) ◽  
pp. 3521-3534 ◽  
Author(s):  
Dharm S. Patel ◽  
Sarah M. Misenko ◽  
Joonyoung Her ◽  
Samuel F. Bunting
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Breaks ◽  
Genomic Integrity ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
General Importance ◽  
Dna Double Strand Break ◽  
Dna Replication And Repair ◽  
In Cells

The BLM gene product, BLM, is a RECQ helicase that is involved in DNA replication and repair of DNA double-strand breaks by the homologous recombination (HR) pathway. During HR, BLM has both pro- and anti-recombinogenic activities, either of which may contribute to maintenance of genomic integrity. We find that in cells expressing a mutant version of BRCA1, an essential HR factor, ablation of BLM rescues genomic integrity and cell survival in the presence of DNA double-strand breaks. Improved genomic integrity in these cells is linked to a substantial increase in the stability of RAD51 at DNA double-strand break sites and in the overall efficiency of HR. Ablation of BLM also rescues RAD51 foci and HR in cells lacking BRCA2 or XRCC2. These results indicate that the anti-recombinase activity of BLM is of general importance for normal retention of RAD51 at DNA break sites and regulation of HR.

Sign in / Sign up

Export Citation Format

Share Document