Tissue engineered platforms for studying primary and metastatic neoplasm behavior in bone

Abstract Context.—Immunohistochemistry has become an integral component of the practice of pathology. Newer antibodies allow for increasingly precise diagnoses for tumors that previously could not be easily identified. Recently, immunohistochemical evaluations have begun to allow pathologists to actively assist in determining prognosis and even in selecting therapies. Objective.—To summarize the usefulness of currently available immunostains for the study of liver and gastrointestinal system neoplasms and to make recommendations for panels of immunostains that can be particularly helpful. Data Sources.—Information has been collected from recent literature as well as from personal experience and practice. Conclusions.—Many immunostains are now available for the practicing pathologist that allow for increasing accuracy in diagnosis of liver and gastrointestinal tract neoplasms. Panels of immunostains can be used to differentiate between various tumors and also to identify site of origin in the case of a metastatic neoplasm. Immunostains that allow for prognostic determinations and for guidance in the selection of chemotherapeutic agents can also be used by pathologists to assist in the management of patients with malignant tumors affecting the liver and gastrointestinal tract.

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Metastatic Neoplasm to the Kidney

Radiology ◽

10.1148/92.5.989 ◽

1969 ◽

Vol 92 (5) ◽

pp. 989-993 ◽

Cited By ~ 30

Author(s):

Morton A. Bosniak ◽

Wilhelm Stern ◽

Filemon Lopez ◽

Nasser Tehranian ◽

Stephen J. O'connor

Keyword(s):

Metastatic Neoplasm

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Histomorphological Pattern of Cervical Lymphadenopathy

Journal of Enam Medical College ◽

10.3329/jemc.v3i1.13837 ◽

2013 ◽

Vol 3 (1) ◽

pp. 13-17 ◽

Cited By ~ 1

Author(s):

Md Atiqur Rahman ◽

Md Mamun Ali Biswas ◽

Syeda Tasfia Siddika ◽

Abdul Mannan Sikder

Keyword(s):

Lymph Node ◽

Lymph Nodes ◽

Hodgkin Lymphoma ◽

Cervical Lymphadenopathy ◽

Histological Evaluation ◽

Cervical Lymph Nodes ◽

Female Ratio ◽

Study Results ◽

Metastatic Neoplasm ◽

Age And Sex

Background: Enlarged palpable cervical lymph nodes as a primary presenting sign are very common and may be due to inflammatory lesions and tumors. Correlation between clinical findings and laboratory data is essential in arriving at a diagnosis. In patients presenting with cervical lymphadenopathy, excision biopsy provides material to establish an early diagnosis. We designed this study in our population for histological evaluation of cervical lymph node biopsies that might be important in the management of these patients. Objective: Histopathological evaluation of different diseases involving the cervical lymph nodes in relation to age and sex of the study population. Materials and Methods: It was a cross sectional study conducted in the department of Pathology, Enam Medical College & Hospital, Savar, Dhaka during the period from January 2006 to December 2010. A total of 107 patients were evaluated for specific cause of cervical lymphadenopathy in relation to age and sex. Lymph node biopsies of all patients of both sexes and all age groups were included in the study. Results: Among the 107 subjects 58 (54.2%) were males and 49 (45.8%) were females with a male to female ratio of 1.2:1. The age of the patients ranged from 2 to 85 years with a mean age of 32.68 ± 18.01 years. Of the 107 lymph node biopsies, 34 cases (31.8%) were reactive lymphadenitis, 41 cases (38.3%) were tuberculosis, 2 cases (1.9%) were non-caseous granuloma, 6 cases (5.6%) were Hodgkin lymphoma, 8 cases (7.5%) were non-Hodgkin lymphoma, 12 cases (11.2%) were metastatic neoplasm and 4 cases (3.7%) were other specific lesions. Conclusion: The commonest cause of cervical lymphadenopathy was tuberculosis, followed by reactive lymphadenitis, lymphoma and metastatic neoplasm. DOI: http://dx.doi.org/10.3329/jemc.v3i1.13837 J Enam Med Col 2013; 3(1): 13-17

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Benign Hematology

10.1093/med/9780199755691.003.0294 ◽

2012 ◽

Author(s):

David P. Steensma

Keyword(s):

Autosomal Recessive ◽

Autosomal Dominant ◽

Porphyria Cutanea Tarda ◽

Vitamin B12 Deficiency ◽

Hematologic Neoplasm ◽

Congenital Erythropoietic Porphyria ◽

Disease Penetrance ◽

B12 Deficiency ◽

Metastatic Neoplasm ◽

Bone Marrow Blood

The major forms of benign hematologic conditions are anemia, neutropenia, transfusion reactions, Gaucher disease, and porphyria. Anemia is a sign of disease rather than a disease itself. Anemia results from 1 or more of 3 pathologic mechanisms: inadequate production of red blood cells (RBCs) by the bone marrow, blood loss, or premature destruction of RBCs. The major causes of neutropenia include hematologic neoplasm, metastatic neoplasm involving the marrow, irradiation, vitamin B12 deficiency and folate deficiency, drugs, infections, congenital or acquired primary disorders of hematopoiesis, autoimmune neutropenia, hypersplenism, hemodilution, and benign idiopathic neutropenia. The porphyrias are enzyme disorders that are autosomal dominant with low disease penetrance, except for congenital erythropoietic porphyria, which is autosomal recessive, and porphyria cutanea tarda, which may be acquired and is associated with hepatitis C and hemochromatosis.

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Carcinoma Metastatic to a Cerebellar Vascular Malformation: Case Report

Neurosurgery ◽

10.1227/00006123-199006000-00023 ◽

1990 ◽

Vol 26 (6) ◽

pp. 1054-1057 ◽

Cited By ~ 1

Author(s):

George M. Greene ◽

Michael N. Hart ◽

Marshall M. Poor ◽

Christopher M. Loftus

Keyword(s):

Case Report ◽

Metastatic Disease ◽

Vascular Malformation ◽

Metastatic Adenocarcinoma ◽

The Rich ◽

Metastatic Neoplasm

Abstract A 73-year-old woman with a spontaneous intracerebellar hemorrhage was seen and was found to have metastatic adenocarcinoma within a vascular malformation. There was no evidence of other metastatic disease. The association of these two lesions is uncommon and has rarely been reported. The rich vascularity of the malformation may explain the hematogenous deposition of metastatic neoplasm at this site.

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Epidermal growth factor receptor (EGFR) status in different stages of resected non-small cell lung cancer (NSCLC): Implications for treatment with EGFR-targeted monoclonal antibodies

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.20015 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 20015-20015

Author(s):

R. Berardi ◽

M. Scartozzi ◽

M. Squadroni ◽

A. Santinelli ◽

A. Brunelli ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Treatment Strategies ◽

Growth Factor Receptor ◽

Background Level ◽

Prognostic Indicator ◽

Egfr Expression ◽

Resected Nsclc ◽

Advanced Stages ◽

Epidermal Growth ◽

Metastatic Neoplasm

20015 Background: Aim of our study was to verify potential changes in EGFR status in different stages of resected NSCLC. This was done in order to find out whether assessing the EGFR status could be considered an effective tool for planning therapy with EGFR-targeted monoclonal antibodies in different setting of patients. Methods: From January 1996 through December 2001, 439 patients underwent radical surgery for NSCLC at the Department of Thoracic Surgery of Università Politecnica delle Marche. EGFR expression was evaluated with an immunohistochemical technique on five micron-thick tissue sections obtained from specimens fixed in 10% (v/v) neutral buffered formalin and paraffin embedded.EGFR expression was detected as membranous and/or cytoplasmic brown staining of neoplastic cells with various intensity. Positivity for EGFR expression was defined as any membrane staining above background level. Both the primary and metastatic neoplasm were considered positive when ≥ 1% of the tumour cells had membranous staining. Results: Table 1 summarizes patients’ characteristics. Samples from 423 patients were available for EGFR analysis. EGFR immunohistochemical expression was found positive as follows: 15.8% in stage IIIB, 12.2% in IIIA, 2.3% in IIB, 5.3% in IIA, 4.8% in IB and 5% in IA. At multivariate analysis, EGFR status resulted indicator of prognosis both when considering all the patients and in the groups of patients with different stages of disease. Conclusions: Globally our findings seem to confirm the role of EGFR as a prognostic indicator in NSCLC. Furthermore the observation that EGFR is more frequently overexpressed in the advanced stages may suggest that EGFR-targeted treatment strategies could be more appropriated in this subgroup of patients. [Table: see text] No significant financial relationships to disclose.

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Kikuchi's disease—Apparent malignancy of a neck mass

The Journal of Laryngology & Otology ◽

10.1017/s0022215100106875 ◽

1988 ◽

Vol 102 (10) ◽

pp. 941-944 ◽

Cited By ~ 1

Author(s):

J. G. Buckley ◽

A. Hinton ◽

C. Allien

Keyword(s):

Cervical Lymphadenopathy ◽

Rare Condition ◽

Neck Mass ◽

Kikuchi’S Disease ◽

Metastatic Neoplasm ◽

Kikuchi's Disease

AbstractWe report a case of Kikuchi's disease presenting as cervical lymphadenopathy in an adolescent. The original histololgical diagnosis in this case was a metastatic neoplasm. We wish to highlight the importance of this rare condition because of its potential for mimicking malignancy.

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Retroperitoneal fibrosis secondary to metastatic neoplasm

Urology ◽

10.1016/0090-4295(77)90198-4 ◽

1977 ◽

Vol 9 (2) ◽

pp. 191-194 ◽

Cited By ~ 27

Author(s):

Sol M. Usher ◽

Herbert Brendler ◽

Vincent A. Ciavarra

Keyword(s):

Retroperitoneal Fibrosis ◽

Metastatic Neoplasm

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