Hematopoiesis-supportive function of growth-arrested human adipose-tissue stromal cells under physiological hypoxia

2019 ◽  
Vol 127 (5) ◽  
pp. 647-654 ◽  
Author(s):  
Elena Andreeva ◽  
Irina Andrianova ◽  
Elena Sotnezova ◽  
Aleksandra Gornostaeva ◽  
Svetlana Khorkova ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stromal Cells ◽  
Human Adipose Tissue ◽  
Adipose Tissue Stromal Cells ◽  
Supportive Function

scholarly journals CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation

2020 ◽  
Vol 21 (21) ◽  
pp. 7907
Author(s):  
Meike Dahlhaus ◽  
Julian Roos ◽  
Daniel Engel ◽  
Daniel Tews ◽  
Daniel Halbgebauer ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stromal Cells ◽  
Adipocyte Differentiation ◽  
Human Adipose Tissue ◽  
Brown Adipocyte ◽  
White Adipocyte ◽  
White Adipocytes ◽  
Brown Adipose ◽  
Adipose Tissue Stromal Cells ◽  
Flow Cytometric Sorting

Brown adipose tissue (BAT) is a thermogenic organ in rodents and humans. In mice, the transplantation of BAT has been successfully used to combat obesity and its comorbidities. While such beneficial properties of BAT are now evident, the developmental and cellular origins of brown, beige, and white adipocytes have remained only poorly understood, especially in humans. We recently discovered that CD90 is highly expressed in stromal cells isolated from human white adipose tissue (WAT) compared to BAT. Here, we studied whether CD90 interferes with brown or white adipogenesis or white adipocyte beiging. We applied flow cytometric sorting of human adipose tissue stromal cells (ASCs), a CRISPR/Cas9 knockout strategy in the human Simpson-Golabi-Behmel syndrome (SGBS) adipocyte model system, as well as a siRNA approach in human approaches supports the hypothesis that CD90 affects brown or white adipogenesis or white adipocyte beiging in humans. Taken together, our findings call the conclusions drawn from previous studies, which claimed a central role of CD90 in adipocyte differentiation, into question.

scholarly journals miR-137 Controls Proliferation and Differentiation of Human Adipose Tissue Stromal Cells

2014 ◽  
Vol 33 (3) ◽  
pp. 758-768 ◽  
Author(s):  
Keun Koo Shin ◽  
Young Suk Kim ◽  
Jee Young Kim ◽  
Yong Chan Bae ◽  
Jin Sup Jung
Keyword(s):  
Adipose Tissue ◽  
Stromal Cells ◽  
Human Adipose Tissue ◽  
Proliferation And Differentiation ◽  
Adipose Tissue Stromal Cells

Aromatization of Androstenedione by Human Adipose Tissue Stromal Cells in Monolayer Culture*

1981 ◽  
Vol 53 (2) ◽  
pp. 412-417 ◽  
Author(s):  
GARY E. ACKERMAN ◽  
MARGARET E. SMITH ◽  
CAROLE R. MENDELSON ◽  
PAUL C. MACDONALD ◽  
EVAN R. SIMPSON
Keyword(s):  
Adipose Tissue ◽  
Stromal Cells ◽  
Monolayer Culture ◽  
Human Adipose Tissue ◽  
Adipose Tissue Stromal Cells

Aromatase activity in human adipose tissue stromal cells: effect of growth factors

Steroids ◽  
1990 ◽  
Vol 55 (12) ◽  
pp. 540-544 ◽  
Author(s):  
Pichai Lueprasitsakul ◽  
Debra Latour ◽  
Christopher Longcope
Keyword(s):  
Adipose Tissue ◽  
Growth Factors ◽  
Stromal Cells ◽  
Human Adipose Tissue ◽  
Aromatase Activity ◽  
Adipose Tissue Stromal Cells

Thiazolidinediones and glucocorticoids synergistically induce differentiation of human adipose tissue stromal cells: Biochemical, cellular, and molecular analysis

Metabolism ◽  
2001 ◽  
Vol 50 (4) ◽  
pp. 407-413 ◽  
Author(s):  
Yuan-Di C. Halvorsen ◽  
Arden Bond ◽  
Anindita Sen ◽  
Dawn M. Franklin ◽  
Y.Renee Lea-Currie ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Molecular Analysis ◽  
Stromal Cells ◽  
Human Adipose Tissue ◽  
Adipose Tissue Stromal Cells
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