Liquid chromatography and tandem mass spectrometry method for the quantitative determination of saxagliptin and its major pharmacologically active 5-monohydroxy metabolite in human plasma: Method validation and overcoming specific and non-specific binding at low concentrations

2012 ◽  
Vol 889-890 ◽  
pp. 77-86 ◽  
Author(s):  
Xiaohui (Sophia) Xu ◽  
Roger Demers ◽  
Huidong Gu ◽  
Lisa J. Christopher ◽  
Hong Su ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Quantitative Determination ◽  
Specific Binding ◽  
Tandem Mass ◽  
Spectrometry Method ◽  
Low Concentrations ◽  
Pharmacologically Active
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