scholarly journals Method development and validation for the quantitation of the complement inhibitor Cp40 in human and cynomolgus monkey plasma by UPLC-ESI-MS

2017 ◽  
Vol 1041-1042 ◽  
pp. 19-26 ◽  
Author(s):  
Alexandra Primikyri ◽  
Malvina Papanastasiou ◽  
Yiannis Sarigiannis ◽  
Sophia Koutsogiannaki ◽  
Edimara S. Reis ◽  
...  
Keyword(s):  
Cynomolgus Monkey ◽  
Method Development ◽  
Complement Inhibitor ◽  
Esi Ms ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Monkey Plasma

scholarly journals Quantitative Method Development and Validation of Naloxone and 6α‐naloxol from Male African Green Monkey Plasma.

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Veera Venkata Ratnam Bandaru ◽  
Justin N Vignola ◽  
Samantha R Litvin ◽  
Amber M Packer ◽  
Amy S Rizkallah ◽  
...  
Keyword(s):  
Quantitative Method ◽  
Method Development ◽  
African Green Monkey ◽  
Green Monkey ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Monkey Plasma

Special Emphasis on Bioanalytical Method Development and Validation of an Anti-Hypertensive Drug Azelnidipine by LC-ESI-MS/MS in Healthy Human Volunteer’s Blood Plasma

2021 ◽  
pp. 3571-3577
Author(s):  
Dibya Das ◽  
Dhiman Halder ◽  
Himangshu Sekhar Maji ◽  
Pintu Kumar De ◽  
Tapan Kumar Pal
Keyword(s):  
Method Development ◽  
Ammonium Acetate ◽  
Channel Blocker ◽  
Healthy Human ◽  
Bioanalytical Method ◽  
Esi Ms ◽  
Validation Parameters ◽  
Method Development And Validation ◽  
Hypertensive Drug ◽  
Development And Validation

The aim of this study is to develop and validate an accurate, sensitive, rapid, precise, and simple bioanalytical method for the estimation of Azelnidipine (calcium channel blocker, used in hypertension) in the human plasma by using LC-ESI-MS/MS. The method was developed by gradient conditions using 0.1% Formic Acid in Acetonitrile and Milli-Q water with 10mM Ammonium acetate as a mobile phase with a flow rate of 0.5 mL/min. The Analyte and IS (Metoprolol) were separated by using a C18 Phenomenex Kinetex (50x3mm, 5µ) column. 7.0 minutes was the chromatographic run time. The analyte and IS extracted from plasma by simple protein precipitation technique (PPT). The LOD and LLOQ were found to be 0.53125ng/mL and 1.0625ng/mL, respectively. The extraction recovery of the drug from plasma was high. The other validation parameters were found within the range, as mentioned by USFDA and EMA guidelines.

Method Development and Validation for Determination of Indoxacarb Using LC-ESI-MS/MS and Its Dissipation Kinetics in Pigeonpea

2019 ◽  
Vol 13 (3) ◽  
pp. 647-657 ◽  
Author(s):  
Harischandra R Naik ◽  
M. S Pallavi ◽  
Rahul Chawan ◽  
M Bheemanna ◽  
Anand Naik ◽  
...  
Keyword(s):  
Method Development ◽  
Esi Ms ◽  
Dissipation Kinetics ◽  
Method Development And Validation ◽  
Development And Validation
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