The use of FT-IR imaging as an analytical tool for the characterization of drug delivery systems

2003 ◽  
Vol 93 (3) ◽  
pp. 223-248 ◽  
Author(s):  
Carrie A Coutts-Lendon ◽  
Norman A Wright ◽  
Ellen V Mieso ◽  
Jack L Koenig
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Analytical Tool ◽  
Ir Imaging ◽  
Ft Ir

Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems

2018 ◽  
Vol 69 (7) ◽  
pp. 1756-1759 ◽  
Author(s):  
Luminita Confederat ◽  
Iuliana Motrescu ◽  
Sandra Constantin ◽  
Florentina Lupascu ◽  
Lenuta Profire
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Average Diameter ◽  
Delivery Systems ◽  
Cross Linking ◽  
Low Molecular Weight ◽  
Polymeric Systems ◽  
Chitosan Microparticles ◽  
Degree Of Swelling

The aim of this study was to optimize the method used for obtaining microparticles based on chitosan � a biocompatible, biodegradable, and nontoxic polymer, and to characterize the developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation method using pentasodiumtripolyphosphate (TPP) as cross-linking agent. Chitosan with low molecular weight (CSLMW) in concentration which ranged between 0.5 and 5 %, was used while the concentration of cross-linking agent ranged between 1 and 5%. The characterization of the microparticles in terms of shape, uniformity and adhesion was performed in solution and dried state. The size of the microparticles and the degree of swelling were also determined. The structure and the morphology of the developed polymeric systems were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The average diameter of the chitosan microparticles was around 522 �m. The most stable microparticles were obtained using CSLMW 1% and TPP 2% or CSLMW 0.75%and TPP 1%. The micropaticles were spherical, uniform and without flattening. Using CSLMW in concentration of 0.5 % poorly cross-linked and crushed microparticles have been obtained at all TPP concentrations. By optimization of the method, stable chitosan-based micropaticles were obtained which will be used to develop controlled release systems for drug delivery.

Enzymatic characterization of lipid-based drug delivery systems

2005 ◽  
Vol 298 (2) ◽  
pp. 328-332 ◽  
Author(s):  
Helena Ljusberg-Wahren ◽  
Flemming Seier Nielsen ◽  
Mattias Brogård ◽  
Emma Troedsson ◽  
Anette Müllertz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Enzymatic Characterization

Synthesis and characterization of novel dual-responsive nanogels and their application as drug delivery systems

Nanoscale ◽  
2012 ◽  
Vol 4 (8) ◽  
pp. 2694 ◽  
Author(s):  
Jinrong Peng ◽  
Tingting Qi ◽  
Jinfeng Liao ◽  
Min Fan ◽  
Feng Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Synthesis And Characterization ◽  
Dual Responsive

scholarly journals Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology

2013 ◽  
Vol 65 (11-12) ◽  
pp. 1403-1419 ◽  
Author(s):  
Nam-Trung Nguyen ◽  
Seyed Ali Mousavi Shaegh ◽  
Navid Kashaninejad ◽  
Dinh-Tuan Phan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Lab On A Chip ◽  
Delivery Systems ◽  
Chip Technology ◽  
Fabrication And Characterization
Sign in / Sign up

Export Citation Format

Share Document