Inhalation delivery of repurposed drugs for lung cancer: Approaches, benefits and challenges

2021 ◽  
Author(s):  
Popat Kumbhar ◽  
Arehalli Manjappa ◽  
Rohit Shah ◽  
Niraj Kumar Jha ◽  
Sachin Kumar Singh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Inhalation Delivery ◽  
Repurposed Drugs

scholarly journals Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 767-775
Author(s):  
Philip J. Kuehl ◽  
Christin M. Yingling ◽  
Devon Dubose ◽  
Michael Burke ◽  
David A. Revelli ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Inhalation Delivery

scholarly journals Inhalation Delivery and Anti-tumor Activity of Celecoxib in Human Orthotopic Non-Small Cell Lung Cancer Xenograft Model

2006 ◽  
Vol 23 (9) ◽  
pp. 2094-2106 ◽  
Author(s):  
Suniket V. Fulzele ◽  
Abhijit Chatterjee ◽  
Madhu Sudhan Shaik ◽  
Tanise Jackson ◽  
Mandip Singh
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Xenograft Model ◽  
Small Cell ◽  
Small Cell Lung ◽  
Inhalation Delivery ◽  
Anti Tumor Activity

Formulation and clinical perspectives of inhalation-based nanocarrier delivery: a new archetype in lung cancer treatment

2021 ◽  
Vol 12 (5) ◽  
pp. 397-418
Author(s):  
Denish Bardoliwala ◽  
Ankit Javia ◽  
Saikat Ghosh ◽  
Ambikanandan Misra ◽  
Krutika Sawant
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
High Dose ◽  
Lung Cancer Treatment ◽  
Inhalation Delivery ◽  
Lung Cancer Therapy ◽  
Core Part

Despite tremendous research in targeted delivery and specific molecular inhibitors (gene delivery), cytotoxic drug delivery through inhalation has been seen as a core part in the treatment of the lung cancer. Inhalation delivery provides a high dose of the drug directly to the lungs without affecting other body organs, increasing the therapeutic ratio. This article reviews the research performed over the last several decades regarding inhalation delivery of various cancer therapeutics for the treatment of lung cancer. Nevertheless, pulmonary administration of nanocarrier-based cancer therapeutics for lung cancer therapy is still in its infancy and faces greater than expected challenges. This article focuses on the current inhalable nanocarrier-based drugs for lung cancer treatment.

scholarly journals Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 1127-1136 ◽  
Author(s):  
Philip J. Kuehl ◽  
Marcie J. Grimes ◽  
Devon Dubose ◽  
Michael Burke ◽  
David A. Revelli ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Preclinical Model ◽  
Inhalation Delivery

scholarly journals Inhalation Delivery of a Novel Diindolylmethane Derivative for the Treatment of Lung Cancer

2010 ◽  
Vol 9 (11) ◽  
pp. 3003-3014 ◽  
Author(s):  
Nkechi Ichite ◽  
Mahavir Chougule ◽  
Apurva R. Patel ◽  
Tanise Jackson ◽  
Stephen Safe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Inhalation Delivery

scholarly journals Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages

2021 ◽  
Vol 18 (-) ◽  
pp. 0-0
Author(s):  
Yu Han ◽  
Yuming Yang ◽  
Qiuyang Sun ◽  
Bin Li ◽  
Caixia Yue ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Inhalation Delivery ◽  
Lung Cancer Therapy

scholarly journals Inhalation delivery of Telmisartan enhances intratumoral distribution of nanoparticles in lung cancer models

2013 ◽  
Vol 172 (1) ◽  
pp. 86-95 ◽  
Author(s):  
Chandraiah Godugu ◽  
Apurva R. Patel ◽  
Ravi Doddapaneni ◽  
Srujan Marepally ◽  
Tanise Jackson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Inhalation Delivery ◽  
Cancer Models ◽  
Intratumoral Distribution

The potential to treat lung cancer via inhalation of repurposed drugs

2018 ◽  
Vol 133 ◽  
pp. 107-130 ◽  
Author(s):  
Wing-Hin Lee ◽  
Ching-Yee Loo ◽  
Maliheh Ghadiri ◽  
Chean-Ring Leong ◽  
Paul M. Young ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Repurposed Drugs
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