scholarly journals Characterization and aerosol dispersion performance of advanced spray-dried chemotherapeutic PEGylated phospholipid particles for dry powder inhalation delivery in lung cancer

2013 ◽  
Vol 49 (4) ◽  
pp. 699-711 ◽  
Author(s):  
Samantha A. Meenach ◽  
Kimberly W. Anderson ◽  
J. Zach Hilt ◽  
Ronald C. McGarry ◽  
Heidi M. Mansour
Keyword(s):  
Lung Cancer ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Inhalation Delivery ◽  
Aerosol Dispersion ◽  
Spray Dried

scholarly journals Development of an Innovative, Carrier-Based Dry Powder Inhalation Formulation Containing Spray-Dried Meloxicam Potassium to Improve the In Vitro and In Silico Aerodynamic Properties

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 535 ◽  
Author(s):  
Edit Benke ◽  
Árpád Farkas ◽  
Piroska Szabó-Révész ◽  
Rita Ambrus
Keyword(s):  
In Silico ◽  
Chronic Obstructive ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Aerodynamic Properties ◽  
Drug Concentrations ◽  
Anti Inflammatory ◽  
New Formulation ◽  
Spray Dried

Most of the marketed dry powder inhalation (DPI) products are traditional, carrier-based formulations with low drug concentrations deposited in the lung. However, due to their advantageous properties, their development has become justified. In our present work, we developed an innovative, carrier-based DPI system, which is an interactive physical blend of a surface-modified carrier and a spray-dried drug with suitable shape and size for pulmonary application. Meloxicam potassium, a nonsteroidal anti-inflammatory drug (NSAID), was used as an active ingredient due to its local anti-inflammatory effect and ability to decrease the progression of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The results of the in vitro and in silico investigations showed high lung deposition in the case of this new formulation, confirming that the interparticle interactions were changed favorably.

scholarly journals Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols

2016 ◽  
Vol Volume 10 ◽  
pp. 4017-4030 ◽  
Author(s):  
Hyo-Jung Lee ◽  
Ji-Hyun Kang ◽  
Hong-Goo Lee ◽  
Dong-Wook Kim ◽  
Yun-Seok Rhee ◽  
...  
Keyword(s):  
Physicochemical Characterization ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Spray Dried
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