Patterns of HCV-RNA and HCV core antigen in the early monitoring of standard treatment for chronic hepatitis C

2013 ◽  
Vol 56 (3) ◽  
pp. 291-295 ◽  
Author(s):  
Elisabetta Loggi ◽  
Carmela Cursaro ◽  
Alessandra Scuteri ◽  
Elena Grandini ◽  
Arianna Martello Panno ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Standard Treatment ◽  
Core Antigen ◽  
Hcv Rna ◽  
Hcv Core Antigen

scholarly journals Serum HCV core antigen level is a useful prediction marker of serum HCV RNA negative at 24-week-treatment with peginterferon and ribavirin in patients with chronic hepatitis C

Kanzo ◽  
2006 ◽  
Vol 47 (8) ◽  
pp. 411-412
Author(s):  
Satoshi Shakado ◽  
Takashi Tanaka ◽  
Shinjiro Inomata ◽  
Akira Anan ◽  
Teruo Matsumoto ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Core Antigen ◽  
Hcv Rna ◽  
Antigen Level ◽  
Hcv Core Antigen ◽  
Peginterferon And Ribavirin

scholarly journals Quantification of Core Antigen Monitors Efficacy of Combination Therapy of Sofosbuvir, Daclatasvir and Ribavirin in Egyptian Cirrhotic Patients with HCV Infection as an Alternative to PCR

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
E H Nashaat ◽  
H Abdel-azziz ◽  
A I Mohammed ◽  
A H Hassan
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Combination Therapy ◽  
Chronic Hepatitis C ◽  
Hcv Infection ◽  
Core Antigen ◽  
Hcv Rna ◽  
Major Public Health Problem ◽  
Hcv Core Antigen ◽  
Cirrhotic Patients

Abstract Background Hepatitis C virus (HCV) is a major public health problem throughout the world. Acute HCV infection is asymptomatic in most cases, and only 15% of cases are symptomatic,but Chronic hepatitis C (CHC) shows a variable clinical course, ranging from mild histopathological changes to active hepatitis and the development of hepatic fibrosis, cirrhosis and HCC. The aim of this work is to detect accuracy of core antigen in Egyptian cirrhotic patients with HCV Infection treated with combination therapy of Sofosbuvir, Daclatasvir and Ribavirin as an alternative to PCR. Patients and methods: The study included20 Egyptian treatment-naïve chronic hepatitis C patients with cirrhosis (Cirrhosis was diagnosed on ultrasound basis) on Sofosbuvir, Daclatasvir and Ribavirin. Results Treatment with sofosbuvir plus Daclatasvir and Ribavirin for 12 weeks resulted in undetectable HCV RNA by PCR in 95% (19/20) of the patients at the end of treatment and only 5% (1/20) of the patients achieved SVR after 6 months not 3(both HCV RNA AND HCV Core Antigen tests were negative for all patients). Conclusion: In our study there was a correlation between HCV RNA and HCV core antigen results, so HCV core antigen can be used as an alternative marker to HCV RNA in treatment of HCV infected cirrhotic patients receiving Sofosbuvir, Daclatasvir and Ribavirin.during treatment and for monitoring its efficacy.

scholarly journals Influence of OASL gene polymorphisms on host response to interferon therapy in chronic hepatitis C virus patients

2017 ◽  
Vol 1 (2) ◽  
pp. 117-125
Author(s):  
Sanja Kiprijanovska ◽  
Emilija Sukarova Stefanovska ◽  
Predrag Noveski ◽  
Viktorija Chaloska Ivanova ◽  
Dijana Plaseska-Karanfilska
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Host Response ◽  
Standard Treatment ◽  
Public Health Problem ◽  
Hcv Rna ◽  
Major Public Health Problem ◽  
Oligoadenylate Synthetase

Abstract Hepatitis C virus (HCV) infection becomes a major public health problem and leading cause of chronic liver disease and liver failure. Pegylated interferon-alfa and ribavirin are currently the standard treatment for chronic hepatitis C (CHC). It is indicated that genes that trace the interferon signaling could be associated with the host response to the therapy. In order to investigate the influence of these genes on host related response, we have analyzed seven single nucleotide polymorphisms (rs59248852, rs74390571, rs12811390, rs1169279, rs3213545, rs1083129 and rs2859398) in 2-5-Oligoadenylate- Synthetase-Like (OASL) gene in CHC cases from Republic of Macedonia. A simple and easy to use SNaPshot method was developed. A cohort of 100 HCV RNA positive patients - non responders and 109 patients with achieved virological response after the standard treatment were included in this study. We have found significant association in five of the seven studied SNP` s: rs59248852 [p = 6.5x10-31, OR=55.7 (20.0-155.3)]; rs12811390 [p = 2.2x10-11, OR=4.3 (2.3-6.7)]; rs2859398 [p=1.34x10-9, OR=3.4 (2.2-5.0)]; rs74390571 [p=4.3x10-7, OR=2.9 (1.9-4.4)], and rs1083129 [p=0.0139, OR=2.0 (1.1-3.5)]. The results from this study can be used as a predictive factor of future patient’s selection for the standard therapy, having an important cost benefit for the health insurance system.

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