scholarly journals Human mesenchymal stem cells provide protection against radiation-induced liver injury by antioxidative process, vasculature protection, hepatocyte differentiation and trophic effects

Cytotherapy ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. S35-S36 ◽  
Author(s):  
S. Francois ◽  
M. Mouiseddine ◽  
B. Allenet-Lepage ◽  
J. Voswinkel ◽  
L. Douay ◽  
...  
Dose-Response ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 155932581989321 ◽  
Author(s):  
Ningning He ◽  
Changyan Xiao ◽  
Yuxiao Sun ◽  
Yan Wang ◽  
Liqing Du ◽  
...  

Mesenchymal stem cells (MSCs) derived from different tissues may aid in the regeneration of radiation-induced organ lesions; however, the radiation responses of human MSCs from different sources are unknown. In our study, a comparison of the results from cell proliferation, apoptosis, cell cycle, DNA damage, and DNA repair assays consistently showed that MSCs derived from adipose tissue possess a significantly stronger radiation resistance capacity than MSCs derived from umbilical cord and gingival, which is accompanied by a higher level of phosphorylated signal transducer and activator of transcription 3 (Stat3) expression. This reminds us Stat3 could be a potential biomarker of radiation resistance. These findings provide a better understanding of radiation-induced biologic responses in MSCs and may lead to the development of better strategies for stem cell treatment and cancer therapy.


PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0119334 ◽  
Author(s):  
Séverine Cruet-Hennequart ◽  
Carole Drougard ◽  
Georgina Shaw ◽  
Florence Legendre ◽  
Magali Demoor ◽  
...  

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  

2012 ◽  
Vol 2 (1_suppl) ◽  
pp. s-0032-1320001-s-0032-1320001
Author(s):  
F. Mwale ◽  
H. T. Wang ◽  
L. Haglund ◽  
P. J. Roughley ◽  
J. Antoniou

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