Combined dosage form of pioglitazone and felodipine as mucoadhesive pellets via hot melt extrusion for improved buccal delivery with application of quality by design approach

2015 ◽  
Vol 30 ◽  
pp. 209-219 ◽  
Author(s):  
Chinna Reddy Palem ◽  
Narender Dudhipala ◽  
Sunil Kumar Battu ◽  
Satyanarayana Goda ◽  
Michael A. Repka ◽  
...  
Keyword(s):  
Dosage Form ◽  
Quality By Design ◽  
Hot Melt Extrusion ◽  
Design Approach ◽  
Buccal Delivery ◽  
Melt Extrusion ◽  
Quality By Design Approach ◽  
Hot Melt

Development of sustained-release formulations processed by hot-melt extrusion by using a quality-by-design approach

2014 ◽  
Vol 4 (4) ◽  
pp. 377-387 ◽  
Author(s):  
Muhammad T. Islam ◽  
Mohammed Maniruzzaman ◽  
Sheelagh A. Halsey ◽  
Babur Z. Chowdhry ◽  
Dennis Douroumis
Keyword(s):  
Sustained Release ◽  
Quality By Design ◽  
Hot Melt Extrusion ◽  
Design Approach ◽  
Melt Extrusion ◽  
Quality By Design Approach ◽  
Hot Melt

Quality-by-Design Approach for Optimization and Processing of PLGA Polymer Film by Hot Melt Extrusion

2022 ◽  
Author(s):  
Midhu George Veeran ◽  
Resmy Rachel Thomas ◽  
Reshmi Ramakrishnan ◽  
Bharaniraja B ◽  
Abi Santhosh Aprem
Keyword(s):  
Polymer Film ◽  
Quality By Design ◽  
Hot Melt Extrusion ◽  
Design Approach ◽  
Melt Extrusion ◽  
Quality By Design Approach ◽  
Hot Melt

scholarly journals Downstream processing from hot-melt extrusion towards tablets: A quality by design approach

2017 ◽  
Vol 531 (1) ◽  
pp. 235-245 ◽  
Author(s):  
W. Grymonpré ◽  
N. Bostijn ◽  
S.Van Herck ◽  
G. Verstraete ◽  
V. Vanhoorne ◽  
...  
Keyword(s):  
Quality By Design ◽  
Downstream Processing ◽  
Hot Melt Extrusion ◽  
Design Approach ◽  
Melt Extrusion ◽  
Quality By Design Approach ◽  
Hot Melt

scholarly journals A quality by design approach to develop topical creams via hot-melt extrusion technology

2019 ◽  
Vol 136 ◽  
pp. 104948 ◽  
Author(s):  
Nicole S. Mendonsa ◽  
Adwait Pradhan ◽  
Purnendu Sharma ◽  
Rosa M.B. Prado ◽  
S. Narasimha Murthy ◽  
...  
Keyword(s):  
Quality By Design ◽  
Hot Melt Extrusion ◽  
Design Approach ◽  
Melt Extrusion ◽  
Quality By Design Approach ◽  
Extrusion Technology ◽  
Hot Melt

Hot Melt Extrusion and its Application in 3D Printing of Pharmaceuticals

2020 ◽  
Vol 17 ◽  
Author(s):  
Sanjeevani Deshkar ◽  
Mrunali Rathi ◽  
Shital Zambad ◽  
Krishnakant Gandhi
Keyword(s):  
3D Printing ◽  
Dosage Form ◽  
Fused Deposition Modeling ◽  
Hot Melt Extrusion ◽  
Taste Masking ◽  
Melt Extrusion ◽  
Fused Deposition ◽  
Continuous Pharmaceutical Manufacturing ◽  
Solubility Improvement ◽  
Hot Melt

Abstract:: Hot melt extrusion (HME) is a continuous pharmaceutical manufacturing process that has been extensively inves-tigated for solubility improvement and taste masking of active pharmaceutical ingredients. Recently, it is being explored for its application in 3D printing. 3D printing of pharmaceuticals allows flexibility of dosage form design, customization of dosage form for personalized therapy and the possibility of complex designs with the inclusion of multiple actives in a sin-gle unit dosage form. Fused deposition modeling (FDM) is a 3D printing technique with a variety of applications in pharma-ceutical dosage form development. FDM process requires a polymer filament as the starting material that can be obtained by hot melt extrusion. Recent reports suggest enormous applications of a combination of hot melt extrusion and FDM technol-ogy in 3D printing of pharmaceuticals and need to be investigated further. This review in detail describes the HME process along with its application in 3D printing. The review also summarizes the published reports on the application of HME cou-pled with 3D printing technology in drug delivery.

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