Characterization of dexamethasone loaded collagen-chitosan sponge and in vitro release study

Magnesium injection is a suitable approach for replenishment of its ions (Mg++) during neural or tissue injury and stroke to avoids risks associated with abnormally low level of Mg++ in blood. In this study, alginate encapsulated magnesium sulfate microbeads were fabricated by the electrospraying technique for Mg++ delivery. Microbeads were evaluated for particle size and surface morphology using inverted optical microscopy and scanning electron microscopy (SEM) respectively. Average particle size of 200–500 μm for hydrated and 50–200 μm for dry beads were observed. An in vitro release study of Mg++ was performed; revealing a cumulative release of ∼50% within first 24 h. This strategy can potentially be useful for the targeted local delivery of magnesium at required concentrations and subsequently enhance the therapeutic efficacy of magnesium in treating tissue injury or stroke.

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Preparation and Characterization of Zein/Sodium Caseinate/Xanthan Gum Complex for Encapsulation of Piperine and its In Vitro Release Study

Food Biophysics ◽

10.1007/s11483-021-09668-w ◽

2021 ◽

Author(s):

Farzaneh Shirmohammadli ◽

Maryam Nikzad ◽

Ali Asghar Ghoreyshi ◽

Maedeh Mohammadi ◽

Fatemeh Poureini

Keyword(s):

Xanthan Gum ◽

In Vitro Release ◽

Sodium Caseinate ◽

Release Study ◽

Vitro Release

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Physical Characterization of Drug Loaded Microcapsules and Controlled In Vitro Release Study

The Open Biomaterials Journal ◽

10.2174/1876502501002010009 ◽

2010 ◽

Vol 2 ◽

pp. 9-7 ◽

Cited By ~ 18

Author(s):

S Jaya ◽

T.D Durance ◽

R Wang

Keyword(s):

In Vitro Release ◽

Physical Characterization ◽

Release Study ◽

Vitro Release

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Preparation, characterization of hydrophilic and hydrophobic drug in combine loaded chitosan/cyclodextrin nanoparticles and in vitro release study

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2010.11.005 ◽

2011 ◽

Vol 83 (1) ◽

pp. 103-107 ◽

Cited By ~ 90

Author(s):

Ji Jingou ◽

Hao Shilei ◽

Liu Weiqi ◽

Wu Danjun ◽

Wang Tengfei ◽

...

Keyword(s):

In Vitro Release ◽

Hydrophobic Drug ◽

Release Study ◽

Vitro Release

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Development, in vitro and in vivo Evaluations of Solid-Lipid Microparticles based on Solidified Micellar Carrier System for Oral Delivery of Cefepime

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2017.10.1.3 ◽

2017 ◽

Vol 10 (1) ◽

pp. 3582-3593

Author(s):

Chukwuebuka Umeyor ◽

Uchechukwu Nnadozie ◽

Anthony Attama

Keyword(s):

Oral Delivery ◽

In Vitro Release ◽

Carrier System ◽

Solid Lipid ◽

Solid Lipid Microparticles ◽

Release Study ◽

Lipid Microparticles ◽

Vitro Release

This study seeks to formulate and evaluate a solid lipid nanoparticle-based, solidified micellar carrier system for oral delivery of cefepime. Cefepime has enjoyed a lot of therapeutic usage in the treatment of susceptible bacterial infections; however, its use is limited due to its administration as an injection only with poor patient compliance. Since oral drug administration encourage high patient compliance with resultant effect in improved therapy, cefepime was formulated as solid lipid microparticles for oral delivery using the concept of solidified micellar carrier system. The carrier system was evaluated based on particle yield, particle size and morphology, encapsulation efficiency (EE %), and thermal analysis using differential scanning calorimeter (DSC). Preliminary microbiological studies were done using gram positive and negative bacteria. In vitro release study was performed using biorelevant media, while in vivo release study was performed in white albino rats. The yield of solid lipid microparticles (SLM) ranged from 84.2 – 98.0 %. The SLM were spherical with size ranges of 3.8 ± 1.2 to 42.0 ± 1.4 µm. The EE % calculated ranged from 83.6 – 94.8 %. Thermal analysis showed that SLM was less crystalline with high potential for drug entrapment. Microbial studies showed that cefepime retained its broad spectrum anti-bacterial activity. In vitro release showed sustained release of cefepime from SLM, and in vivo release study showed high concentration of cefepime released in the plasma of study rats. The study showed that smart engineering of solidified micellar carrier system could be used to improve oral delivery of cefepime.

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Formulation and Evaluation of Sustained Release Dosage Forms of Norfloxacin

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2018.11.6.6 ◽

2018 ◽

Vol 11 (6) ◽

pp. 4331-4337

Author(s):

C Suja ◽

Sismy C

Keyword(s):

Sustained Release ◽

Guar Gum ◽

In Vitro Release ◽

Angle Of Repose ◽

Prolonged Release ◽

Weight Variation ◽

Sustained Release Tablets ◽

Release Study ◽

Vitro Release

The goal of this study was to formulate and evaluate norfloxacin sustained release tablets. Norfloxacin sustained release tablets were prepared by wet granulation method using two polymers such as HPMC K 100 M (hydrophilic polymer) and guar gum (natural polymer) and with three polymer ratios (0.5, 1.0 and 1.5). The prepared granules were evaluated to preformulation studies such as angle of repose, bulk density, tapped density, bulkiness, compressibility index and Hauser’s ratio. All the parameters shows that the granules having good flow properties. Then the formulated tablets were taken to evaluation studies such as hardness, weight variation, friability, drug content and thickness. All the parameters were within the acceptable limits. IR spectral analysis showed that there was no interaction between the drug and polymers. The in vitro release study was performed in phosphate buffer pH 7.4 at 293 nm. The in vitro release study showed that if the polymer ratio is increased, then the release of the drug is prolonged. HPMC K 100M shows a prolonged release when compared to guar gum.

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