Efficacy of a self-assembling peptide to remineralize initial caries lesions - a systematic review and meta-analysis

This systematic review and meta-analysis aimed to investigate the efficacy of fluorescence-based methods, visual inspections, and photographic visual examinations in initial caries detection. A literature search was undertaken in the PubMed and Cochrane databases. Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines were followed, and eligible articles published from 1 January 2009 to 30 October 2019 were included if they met the following criteria: they (1) assessed the accuracy of methods of detecting initial tooth caries lesions on occlusal, proximal, or smooth surfaces in both primary and permanent teeth (in clinical); (2) used a reference standard; (3) reported data regarding the sample size, prevalence of initial tooth caries, and accuracy of the methods. Data collection and extraction, quality assessment, and data analysis were conducted according to Cochrane standards Quality Assessment of Diagnostic Accuracy Studies-2. Statistical analyses were performed using Review Manager 5.3 and STATA 14.0. A total of 12 eligible articles were included in the meta-analysis. The results showed that the sensitivity and specificity of fluorescence-based methods were 80% and 80%, respectively; visual inspection was measured at 80% and 75%, respectively; photographic visual examination was measured at 67% and 79%, respectively. We found that the visual method and the fluorescence method were reliable for laboratory use to detect early-stage caries with equivalent accuracy.

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Is Atraumatic restorative treatment an option for restoring occlusoproximal caries lesions in primary teeth? A systematic review and meta-analysis

International Journal of Paediatric Dentistry ◽

10.1111/ipd.12013 ◽

2012 ◽

pp. n/a-n/a ◽

Cited By ~ 7

Author(s):

Daniela P. Raggio ◽

Daniela Hesse ◽

Tathiane L. Lenzi ◽

Camila A. B. Guglielmi ◽

Mariana M. Braga

Keyword(s):

Systematic Review ◽

Primary Teeth ◽

Meta Analysis ◽

Atraumatic Restorative Treatment ◽

Restorative Treatment ◽

Caries Lesions

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Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis

BMC Oral Health ◽

10.1186/s12903-020-01364-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yuanyuan Chen ◽

Dongru Chen ◽

Huancai Lin

Keyword(s):

Systematic Review ◽

High Risk ◽

Meta Analysis ◽

Low Risk ◽

Caries Risk ◽

Moderate Risk ◽

Risk Levels ◽

Non Invasive ◽

Randomised Controlled ◽

Caries Lesions

Abstract Background Infiltration and sealing are micro-invasive treatments for arresting proximal non-cavitated caries lesions; however, their efficacies under different conditions remain unknown. This systematic review and meta-analysis aimed to evaluate the caries-arresting effectiveness of infiltration and sealing and to further analyse their efficacies across different dentition types and caries risk levels. Methods Six electronic databases were searched for published literature, and references were manually searched. Split-mouth randomised controlled trials (RCTs) to compare the effectiveness between infiltration/sealing and non-invasive treatments in proximal lesions were included. The primary outcome was obtained from radiographical readings. Results In total, 1033 citations were identified, and 17 RCTs (22 articles) were included. Infiltration and sealing reduced the odds of lesion progression (infiltration vs. non-invasive: OR = 0.21, 95% CI 0.15–0.30; sealing vs. placebo: OR = 0.27, 95% CI 0.18–0.42). For both the primary and permanent dentitions, infiltration and sealing were more effective than non-invasive treatments (primary dentition: OR = 0.30, 95% CI 0.20–0.45; permanent dentition: OR = 0.20, 95% CI 0.14–0.28). The overall effects of infiltration and sealing were significantly different from the control effects based on different caries risk levels (OR = 0.20, 95% CI 0.14–0.28). Except for caries risk at moderate levels (moderate risk: OR = 0.32, 95% CI 0.01–8.27), there were significant differences between micro-invasive and non-invasive treatments (low risk: OR = 0.24, 95% CI 0.08–0.72; low to moderate risk: OR = 0.38, 95% CI 0.18–0.81; moderate to high risk: OR = 0.17, 95% CI 0.10–0.29; and high risk: OR = 0.14, 95% CI 0.07–0.28). Except for caries risk at moderate levels (moderate risk: OR = 0.32, 95% CI 0.01–8.27), infiltration was superior (low risk: OR = 0.24, 95% CI 0.08–0.72; low to moderate risk: OR = 0.38, 95% CI 0.18–0.81; moderate to high risk: OR = 0.20, 95% CI 0.10–0.39; and high risk: OR = 0.14, 95% CI 0.05–0.37). Conclusion Infiltration and sealing were more efficacious than non-invasive treatments for halting non-cavitated proximal lesions.

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Management of deep caries lesions with or without pulp involvement in primary teeth: a systematic review and network meta-analysis

Brazilian Oral Research ◽

10.1590/1807-3107bor-2021.vol35.0004 ◽

2021 ◽

Vol 35 ◽

Author(s):

Tamara Kerber Tedesco ◽

Thais Marchezini Reis ◽

Anna Carolina Volpi Mello-Moura ◽

Gabriela Seabra da Silva ◽

Samanta Scarpini ◽

...

Keyword(s):

Systematic Review ◽

Primary Teeth ◽

Meta Analysis ◽

Caries Lesions

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Prevalence of white spot caries lesions in primary teeth in preschool children: systematic review and meta-analysis

Current Pediatric Reviews ◽

10.2174/1573396317666211202090657 ◽

2021 ◽

Vol 17 ◽

Author(s):

Priscila H Campos ◽

Thais Gimenez ◽

Rafael S Rocha ◽

Taciana MF Caneppele ◽

Renata O Guaré ◽

...

Keyword(s):

Systematic Review ◽

Preschool Children ◽

Low Income ◽

Primary Teeth ◽

Meta Analysis ◽

White Spot ◽

White Spot Lesion ◽

Eligibility Criteria ◽

Meta Analyses ◽

Caries Lesions

Background: The first clinically detectable stage of caries lesion is a non-cavitated white spot lesion (WSL). The detection of early stages of caries lesions allows non-invasive management by fluoride usage, oral hygiene and diet control. There is a lack of information in the literature regarding the prevalence of these caries lesions in preschool children, which is important especially for public health strategies. Objective: The aim of this study was to conduct a systematic review with meta-analysis to verify the WSLs prevalence in primary teeth of preschool children. Methods: A literature search with MEDLINE/PubMed, Scopus, Web of Science, and Open Gray databases was conducted. Included studies fulfilled the eligibility criteria. Meta-analyses were performed using random effects model, for prevalence of pooled WSLs and subgroups analyses. Results: The search strategy identified 4922 potentially relevant articles, with final inclusion of 16 studies. The pooled prevalence of WSLs in primary teeth was 14.0% (95% CI: 8.0-24.0), without publication bias (p=0.2668). For subgroup analyses, an increase in WSLs prevalence for children of low-income economy (24.0%; 95% CI: 20.0-28.0), for age >31 months (22.0%; 95% CI: 12.0-37.0), for validated visual criteria assessment (20.0%; 95% CI: 11.0-33.0), and for tactile assessment with ball-ended probe (26.0%; 95% CI: 11-50.0) were detected. Conclusion: It is suggested that the prevalence of WSLs in primary teeth of preschool children increases in countries with low income economy, with age greater than 31 months as the texture was assessed with visual validated criteria or ball-end probe.

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