The ethyl acetate extract of Cordyceps militaris inhibits IgE-mediated allergic responses in mast cells and passive cutaneous anaphylaxis reaction in mice

Mast cells contribute importantly to both protective and pathological IgE-dependent immune responses. We show that the mast cell–expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell–dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice. We further identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. In contrast to other “silent” or professional chemokine interreceptors, chemerin binding does not trigger ligand internalization. Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1.

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Efficacy of Ethyl Acetate Fraction of Cordyceps militaris for Cancer-Related Fatigue in Blood Biochemical and 1H-Nuclear Magnetic Resonance Metabolomic Analyses

Integrative Cancer Therapies ◽

10.1177/1534735420932635 ◽

2020 ◽

Vol 19 ◽

pp. 153473542093263

Author(s):

Junsang Oh ◽

Eunhyun Choi ◽

Jayoung Kim ◽

Heesu Kim ◽

Sangheun Lee ◽

...

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Ethyl Acetate ◽

Ethyl Acetate Extract ◽

Ethyl Acetate Fraction ◽

Cordyceps Militaris ◽

Combination Strategy ◽

Cancer Related Fatigue ◽

Adjuvant Effects ◽

Nuclear Magnetic

This study investigated the adjuvant effects for anticancer and antifatigue of the combination of Cordyceps militaris extract with sorafenib. The 5 extracts of C militaris were obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity. Among these extracts, ethyl acetate extract of C militaris showed the best tumor growth inhibitory activity and the adjuvant effects in combination with sorafenib. As a result of biochemical analysis with serum, the combination of ethyl acetate extract of C militaris with sorafenib showed the adjuvant effects both improving hepatic function and relieving cancer-related fatigue. In addition, 1H-nuclear magnetic resonance–based metabolic profiling in liver tissues showed that the change of metabolism by ethyl acetate extract of C militaris with sorafenib was related with serum fatigue biomarkers. Therefore, the combination strategy such as ethyl acetate extraction of C militaris with sorafenib constitutes a promising therapeutic strategy in hepatocellular carcinoma, via the inhibition of cancer growth, the enhancement of liver function, as well as the alleviation of cancer-related fatigue.

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Inhibitory effect of the branches of Hovenia dulcis Thunb. and its constituent pinosylvin on the activities of IgE-mediated mast cells and passive cutaneous anaphylaxis in mice

Food & Function ◽

10.1039/c4fo01203h ◽

2015 ◽

Vol 6 (4) ◽

pp. 1361-1370 ◽

Cited By ~ 9

Author(s):

Sue Ji Lim ◽

Myungsuk Kim ◽

Ahmad Randy ◽

Chu Won Nho

Keyword(s):

Mast Cells ◽

Middle East ◽

Traditional Medicine ◽

North Africa ◽

Liver Toxicity ◽

Inhibitory Effect ◽

Passive Cutaneous Anaphylaxis ◽

Ige Mediated ◽

Hovenia Dulcis

Hovenia dulcisThunb. is a hardy tree native to Europe, the Middle East, and North Africa, and it is also grown in parts of Asia and has been used in traditional medicine to treat liver toxicity, stomach disorders, and inflammation.

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Flavonoid glucuronides isolated from spinach inhibit IgE-mediated degranulation in basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice

Integrative Molecular Medicine ◽

10.15761/imm.1000119 ◽

2015 ◽

Vol 2 (1) ◽

Cited By ~ 1

Keyword(s):

Passive Cutaneous Anaphylaxis ◽

Ige Mediated ◽

Basophilic Leukemia ◽

Passive Cutaneous Anaphylaxis Reaction

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