Inhibitory Activities of Compounds from the Marine Actinomycete Williamsia sp. MCCC 1A11233 Variant on IgE-Mediated Mast Cells and Passive Cutaneous Anaphylaxis

Mast cells contribute importantly to both protective and pathological IgE-dependent immune responses. We show that the mast cell–expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell–dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice. We further identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. In contrast to other “silent” or professional chemokine interreceptors, chemerin binding does not trigger ligand internalization. Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1.

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Inhibitory effect of the branches of Hovenia dulcis Thunb. and its constituent pinosylvin on the activities of IgE-mediated mast cells and passive cutaneous anaphylaxis in mice

Food & Function ◽

10.1039/c4fo01203h ◽

2015 ◽

Vol 6 (4) ◽

pp. 1361-1370 ◽

Cited By ~ 9

Author(s):

Sue Ji Lim ◽

Myungsuk Kim ◽

Ahmad Randy ◽

Chu Won Nho

Keyword(s):

Mast Cells ◽

Middle East ◽

Traditional Medicine ◽

North Africa ◽

Liver Toxicity ◽

Inhibitory Effect ◽

Passive Cutaneous Anaphylaxis ◽

Ige Mediated ◽

Hovenia Dulcis

Hovenia dulcisThunb. is a hardy tree native to Europe, the Middle East, and North Africa, and it is also grown in parts of Asia and has been used in traditional medicine to treat liver toxicity, stomach disorders, and inflammation.

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Impaired activation of mast cells upon IgE-mediated antigen stimulation in a stroke-prone spontaneously hypertensive rat strain, SHRSP.Z

Immunology Letters ◽

10.1016/j.imlet.2009.11.007 ◽

2010 ◽

Vol 128 (1) ◽

pp. 74-79

Author(s):

Mariko Sakanaka ◽

Kazuyuki Furuta ◽

Atsushi Ichikawa ◽

Satoshi Tanaka

Keyword(s):

Mast Cells ◽

Spontaneously Hypertensive Rat ◽

Spontaneously Hypertensive ◽

Antigen Stimulation ◽

Hypertensive Rat ◽

Rat Strain ◽

Ige Mediated

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The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

Journal of Experimental Medicine ◽

10.1084/jem.20170910 ◽

2017 ◽

Vol 214 (9) ◽

pp. 2491-2506 ◽

Cited By ~ 45

Author(s):

Gökhan Cildir ◽

Harshita Pant ◽

Angel F. Lopez ◽

Vinay Tergaonkar

Keyword(s):

Mast Cell ◽

Mast Cells ◽

Immunoglobulin E ◽

Inflammatory Diseases ◽

Small Population ◽

Transcriptional Program ◽

Cell Functions ◽

New Concepts ◽

Health And Disease ◽

Ige Mediated

Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen–immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.

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