Preservice Teachers Consider Game-Based Teaching and Learning

Gaming has become a core activity with children and more teachers are using games for teaching content than they did five years ago. Yet, teachers report that they learn about game titles, impact studies, and facilitation techniques through their own initiatives or from other teachers rather than from their teacher education program. This chapter reports on a combined curricular strategy built on game strategy research that asked teacher candidates (n= 125) to discuss news headlines about games, play educational games, review games, and game research, teach others how to play educational games, and construct games. Findings reveal that candidates saw value in using games in K-12 to teach content, were able to develop assessments based on game content at a novice level, and were able to construct games either alone or in small groups. Educators contemplating gaming as an instructional strategy may be interested in the espoused combination strategy to encourage game adoption in K-12 settings.

Subsidy and Environmental Tax for Construction and Demolition Waste Recycling

In recent two decades, construction and demolition (C&D) waste is becoming a major source for municipal waste which causes serious damage to the environment. To solve the problem, waste recycling measures are gradually used to turn waste into treasures. Meanwhile, several kinds of policies such as waste disposal charging fees have been issued to stimulate stakeholders’ behavior to take waste recycling measures to promote the C&D waste recycling industry. However, the C&D waste recycling rate is still too low in China. In order to promote C&D waste recycling industrial development, this paper is aiming at introducing subsidy and environmental tax policies to promote C&D waste recycling. Based on system dynamics, this study establishes a model to determine the proper subsidy and environmental tax range. According to the simulation results, three kinds of incentive policies are obtained, namely, single subsidy policy, single environmental tax and combined incentive policies. Optimal single subsidy and environmental tax are in the interval [10, 30] and [20, 60], respectively. The best combination strategy is subsidy=10 yuan /ton and environmental tax=20 yuan/ton. The results from this paper could be a foundation for government to establish incentive policies to promote C&D waste recycling.

A multiscale kernel-based network with improved attention mechanism for rotating machinery fault diagnosis under noisy environment

Considering the vibration signals are easily contaminated by the strong and highly non-stationary noise, extracting more sensitive and effective features from the noised vibration signals is still a great challenge for intelligent fault diagnosis of rotating machinery. This paper proposed a multiscale kernel-based network with improved attention mechanism (IA-MKNet) to overcome this challenge. In the proposed method, an improved attention mechanism (IAM) for multiscale convolution is firstly developed to adaptively extract the meaningful fault features and automatically suppress noise. Then, due to the inherent multiple time characteristics of vibration signals, an adaptive multiscale kernel-based residual block (AMKRB) with IAM is designed to capture fault features in multi-time scales of vibration signals. Finally, a combination strategy based on an adaptive ensemble learner is proposed to increase the diversity of features by fusing the outputs of multiple IA-MKNets, which further improves diagnosis accuracy and stability. The experimental results, verified by two bearing datasets with noise interference, confirm that the proposed method improves the fault diagnosis accuracy of rotating machinery under noisy environment, which performance is superior to the other five benchmark methods.

Minimizing Adverse Effects of Cerenkov Radiation Induced Photodynamic Therapy With Transformable Photosensitizer-loaded Nanovesicles

BackgroundPhotodynamic therapy (PDT) is a promising antitumor strategy with fewer adverse effects and higher selectivity than conventional therapies. Recently, a series of reports have suggested that PDT (CR-PDT) induced by Cerenkov radiation (CR) has deeper tissue penetration than traditional PDT. While the combination strategy by coupling radionuclides with photosensitizers might cause severe side effects. MethodsWe designed tumor-targeting nanoparticles ( 131 I-EM@ALA) by loading 5-Aminolevulinic acid (ALA) into 131 I-labeled exosome mimetic (EM) to achieve combined antitumor therapy. In addition to the role of radiotherapy, 131 I can also serve as an internal light source for its Cerenkov radiation (CR). ResultsThe drug-loaded nanoparticles could effectively target tumors as confirmed by confocal imaging, flow cytometry, and small animal fluorescence imaging. The in vitro and in vivo experiments demonstrated that 131 I-EM@ALA produced a promising antitumor effect by synergizing radiotherapy and CR-PDT. The nanoparticles killed tumor cells by inducing DNA damage and activating the lysosome-mitochondrial pathways. During the treatment, there were no obvious abnormalities found in hematology analyses, blood biochemistry, and histological examinations. ConclusionsWe successfully engineered nanocarrier coloaded with radionuclide 131 I and a photosensitizer precursor for combinational radiotherapy and PDT in treatment of breast cancer.

Utilization of Metallurgy—Beneficiation Combination Strategy to Decrease TiO2 in Titanomagnetite Concentrate before Smelting

Excessive TiO2 in titanomagnetite concentrates (TC) causes unavoidable problems in subsequent smelting. At present, this issue cannot be addressed using traditional mineral processing technology. Herein, a strategy of metallurgy-beneficiation combination to decrease the TiO2 grade in TC before smelting was proposed. Roasting TC with calcium carbonate (CaCO3) together with magnetic separation proved to be a viable strategy. Under optimal conditions (roasting temperature = 1400 °C, CaCO3 ratio = 20%, and magnetic intensity = 0.18 T), iron and titanium was separated efficiently (Fe grade: 56.6 wt.%; Fe recovery: 70 wt.%; TiO2 grade 3 wt.%; TiO2 removal: 84.1 wt.%). X-ray diffraction, scanning electron microscopy, and energy dispersive spectroscopy analysis were used to study the mechanisms. The results showed that Ti in TC could react with CaO to form CaTiO3, and thermodynamic calculations provided a relevant theoretical basis. In sum, the metallurgy-beneficiation combination strategy was proven as an effective method to decrease unwanted TiO2 in TC.

Combination of Ablation and Immunotherapy for Hepatocellular Carcinoma: Where We Are and Where to Go

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide and is increasing in incidence. Local ablative therapy plays a leading role in HCC treatment. Radiofrequency (RFA) is one of the first-line therapies for early local ablation. Other local ablation techniques (e.g., microwave ablation, cryoablation, irreversible electroporation, phototherapy.) have been extensively explored in clinical trials or cell/animal studies but have not yet been established as a standard treatment or applied clinically. On the one hand, single treatment may not meet the needs. On the other hand, ablative therapy can stimulate local and systemic immune effects. The combination strategy of immunotherapy and ablation is reasonable. In this review, we briefly summarized the current status and progress of ablation and immunotherapy for HCC. The immune effects of local ablation and the strategies of combination therapy, especially synergistic strategies based on biomedical materials, were discussed. This review is hoped to provide references for future researches on ablative immunotherapy to arrive to a promising new era of HCC treatment.

Comparative Study of Factors Contributing to Land Surface Temperature in High-Density Built Environments in Megacities Using Satellite Imagery

In this study, the root sources contributing to the urban heat island (UHI) effect between megacities, such as Hong Kong and Shenzhen, were integrated and compared using satellite remote sensing data. Classification and multilayer perceptron regression tree (CARTMLP) algorithms were used to classify land use. The radiative transfer equation method was applied to retrieve the land surface temperatures (LSTs) in the study area. Multiple linear regression analysis was applied to determine the relationship between land-use types and UHIs. The experimental results show a large area of relatively high temperature dispersed within Shenzhen, and comparatively small areas highly centralized in Hong Kong, with the retrieved LST in Hong Kong lower than that in Shenzhen. In addition, the surface temperature of large complex buildings decorated with high-albedo materials in Hong Kong was higher than in Shenzhen (e.g., Hong Kong International Airport, 25.12 °C; Shenzhen Bao’an International Airport, 23.38 °C), with artificial heat being an important contributor to these differences. These results also imply that high-albedo materials are sufficient to alleviate high temperatures. These findings are integrated to propose an organic combination strategy for reducing UHI effects in urban areas in megacities worldwide, such as Hong Kong and Shenzhen in China.